Background: According to the World Health Organization, skin cancer is the
most common malignancy for the population. Conventional skin cancer treatment includes
surgery and chemotherapy, but many of the chemotherapeutic agents used present undesirable
properties. There are a number of patents on topical nano formulation like nanoparticle
(US9757453; US9457041), liposomes (US2018177726 (A1), has been covered in this review
in the treatment of skin cancer.
Methods: Encapsulated drugs are advantageous due to such properties as high stability, better
bioavailability, controlled drug release, a long blood circulation time, selective organ or
tissue distribution, a lower total required dose, and minimal toxic side effects. Today, researchers
are constantly developing new formulations to meet unmet needs in the delivery of
therapeutic agents for cancer therapy and diagnosis, respectively.
Results: Of particular interest here are lipid-based nanoformulations that are formulated
from varieties of lipid and other chemical components that act collectively to overcome biological
barriers, in order to preferentially accumulate in or around disease-target cells for the
functional delivery of therapeutic agents. The article deals with the recent development of
nano-sized topical lipid formulation approaches to treat skin cancer.
Conclusion: We focus especially on the topical lipid formulation approaches combined with
chemotherapy, a field which specialises in target specificity, drug release control, and realtime
monitoring with the goal being to diminish unwanted side effects and their severity,
achieving a cheaper treatment and a generally more efficient chemotherapy.