Mangroves are unique coastal forest ecosystem distributed along the tropical and subtropical
region of the world. They are evolutionarily adapted to combat against hostile environmental
conditions such as low oxygen, high salinity, and temperature. The adaptive features endowed
with novel secondary metabolic pathways and bioactive compounds to sustain in harsh conditions.
The novel metabolites are a rich source of the wide range of bioactive compounds and natural
products. It includes terpenoids, alkaloids, phenolics, saponins, flavonoids, and steroids. The
bioactive and natural compounds may serve as therapeutic precursors and industrial raw materials.
Terpenes and polyphenols have antiviral, antibacterial, antifungal, antimalarial, anticancer or combination
of activities. To date, several mangroves plants were examined and recognized as a potential
source of novel natural product for exploitation in medicine. In fact, most of the isolated compounds
are novel and showed promising biological activities such as gastroprotective, cytotoxic, antioxidant,
antibacterial, antifungal, antiviral, enzyme activation and inhibition, immunosuppressive,
anti-inflammatory, antifeedant effects. In the present review, we have compiled the achievements
and progress in mangroves natural products research of the last decade.