Abstract
Serine protease, Human Neutrophil Elastase (HNE), has been shown to be useful in medical science, however, its over production and malfunctioning may produce devastating effects and cause serious damage to the host. Unfortunately, the present approved drug, sivelestat, only alleviates the symptoms of the diseases caused by malfunction of HNE but not the disease progression. Therefore, there is a crucial need to search potent and safer molecules as elastase inhibitors and to develop better anti-inflammatory drugs in future. In addition, nature is the best architect that may provide a safer future drug candidate as HNEproduction/ activity inhibitor. Since phenolic natural products are already known as antiinflammatory compounds, either by acting as antioxidants or by any other mechanism, thus, this review article summarizes the discovery and elastase inhibitory activity of ∼180 phenolics isolated from diverse natural sources during more than one decade, i.e. 2005-2017.
Keywords: Anti-inflammatory compounds, human neutrophil elastase, inhibitory activity, phenolics, secondary metabolites, disease.
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title:Natural Phenolics as Inhibitors of the Human Neutrophil Elastase (HNE) Release: An Overview of Natural Anti-inflammatory Discoveries during Recent Years
Volume: 17 Issue: 2
Author(s): Muhammad Saleem*, Mamona Nazir, Hidayat Hussain, Muhammad I. Tousif, Mahmoud F. Elsebai, Naheed Riaz and Naseem Akhtar
Affiliation:
- Department of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, 63100 Bahawalpur,Pakistan
Keywords: Anti-inflammatory compounds, human neutrophil elastase, inhibitory activity, phenolics, secondary metabolites, disease.
Abstract: Serine protease, Human Neutrophil Elastase (HNE), has been shown to be useful in medical science, however, its over production and malfunctioning may produce devastating effects and cause serious damage to the host. Unfortunately, the present approved drug, sivelestat, only alleviates the symptoms of the diseases caused by malfunction of HNE but not the disease progression. Therefore, there is a crucial need to search potent and safer molecules as elastase inhibitors and to develop better anti-inflammatory drugs in future. In addition, nature is the best architect that may provide a safer future drug candidate as HNEproduction/ activity inhibitor. Since phenolic natural products are already known as antiinflammatory compounds, either by acting as antioxidants or by any other mechanism, thus, this review article summarizes the discovery and elastase inhibitory activity of ∼180 phenolics isolated from diverse natural sources during more than one decade, i.e. 2005-2017.
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Cite this article as:
Saleem Muhammad*, Nazir Mamona , Hussain Hidayat , Tousif I. Muhammad , Elsebai F. Mahmoud , Riaz Naheed and Akhtar Naseem , Natural Phenolics as Inhibitors of the Human Neutrophil Elastase (HNE) Release: An Overview of Natural Anti-inflammatory Discoveries during Recent Years, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2018; 17 (2) . https://dx.doi.org/10.2174/1871523017666180910104946
DOI https://dx.doi.org/10.2174/1871523017666180910104946 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
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