Background: Bone Marrow (BM) has the self-renovation capacity and has been used recently in tumor
medicine. Chlorambucil [CHB] is ordinarily utilized chemotherapy to treat varieties of malignancy patients. This
investigation intended to gauge the effectiveness of BM as an in-vivo antimutagenic against CHB.
Methods: The experimental design relies upon four classes; each class contains ten adult male albino rats as follows:
control, rats infused orally with CHB for fourteen days, rats intravenously infused with BM through a tail vein one
time, rats infused the mix of CHB and BM.The Anticancer capability of BM was assessed by cytogenetic assay and
mitotic index. The declarations of the apoptosis- related genes were examined by RT-qPCR examination.
Results: The present experiment demonstrated a curative effect of BM against the cytotoxic impact of CHB. Infusion
of BM after chemotherapy helps to diminish the chromosomal aberration; increment mitotic index and decline the
Bax/Bcl2 proportion compared with [CHB] class gather that prompts expanding the survival rate of influenced cells
with chemotherapy cytotoxicity.
Conclusion: The present study shows that bone marrow transplantation together after CHB infusion helps to increase
genomic stability by diminishing structural chromosome abnormalities, diminishing the Bax/Bcl2 proportion and
increasing the mitotic index.