An efficient synthesis of Hantzsch 1,4-dihydropyridines via a one-pot three-component reaction
of ethyl acetoacetate, substituted aldehydes and ammonium acetate in the presence of ZnO@SnO2
mixed metal oxide nanoparticles under solvent-free conditions has been reported. Compare to the reported
reactions, this method shows attractive aspects such as cleaner reaction profile, shorter reaction
times, minimum catalyst loading and high yields. Isolated catalysts were reused for new reactions
without considerable loss of their catalytic activity.
Keywords: 1, 4-Dihydropyridines, one-pot multi component reaction, ZnO@SnO2 nanoparticles, solvent free, catalyst, metal oxide.
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