Background: The immune system is designed with great care to distinguish self from
non-self, as exhibited by immune responses to different pathogens. Furthermore, the immune system
has the capacity to distinguish between self from altered self in case of autoimmune diseases
like cancer. Developing tumors bypass the immune system mechanism which restrains selfreactive
responses. Immunotherapy is a coherent means since the immune system can eliminate a
number of antigens derived from the genetic constitution of B and T lymphocytes. Our understanding
of the immune system has developed a great deal.
Conclusions: This review is focused not only on the mechanism by which the immune system
protects us but also on the ways in which it can inflict the body and how to modulate it with therapy.
Thus, understanding the interaction of a tumor with the immune system provides insights into
mechanisms that can be utilized to elicit anti-tumor immune responses. Here, we have recapitulated
the function of the tumor microenvironment and immune checkpoints.
Keywords: B cell, T cell, Antigen, Cancer, Immunity
Rights & PermissionsPrintExport