A Comprehensive Review of In silico Analysis for Protein S-sulfenylation Sites

Author(s): Md Mehedi Hasan*, Mst Shamima Khatun, Hiroyuki Kurata.

Journal Name: Protein & Peptide Letters

Volume 25 , Issue 9 , 2018

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Abstract:

Background: Cysteine S-sulfenylation is a major type of dynamic post-translational modification of the protein that plays an important role in regulating many biological processes in both of prokaryotic and eukaryotic species. To understand the function of S-sulfenylated proteins, identification of S-sulfenylation sites is an essential step. Due to numerous restrictions of experimental methods, computational prediction of the potential S-sulfenylation sites becomes popular. In this review, we discuss the recent development and challenges in protein S-sulfenylation site prediction from the available datasets, algorithms and accessible services. We also demonstrate the encountered limitation and future perspective of the computational prediction tools.

Conclusion: The development of S-sulfenylation site prediction and their application is an emerging field of protein bioinformatics research. Accurate predictors are expected to identify general and species-specific S-sulfenylation sites when more experimental annotation data are available. Combining experimental and computational technologies will definitely accelerate an understanding of protein S-sulfenylation, discovering regulatory networks in living organisms.

Keywords: S-sulfenylation site, statistical learning, feature representation, tool development, computational prediction tools, regulatory networks.

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Article Details

VOLUME: 25
ISSUE: 9
Year: 2018
Page: [815 - 821]
Pages: 7
DOI: 10.2174/0929866525666180905110619
Price: $58

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