Pyridine and pyrimidine derivatives have received great interest in recent pharmacological
research, being effective in the treatment of various malignancies, such as myeloid
leukemia, breast cancer and idiopathic pulmonary fibrosis. Most of the FDA approved drugs
show a pyridine or pyrimidine core bearing different substituents. The aim of this review is to
describe the most recent reports in this field, with reference to the newly discovered pyridineor
pyrimidine-based drugs, to their synthesis and to the evaluation of the most biologically
active derivatives. The corresponding benzo-fused heterocyclic compounds, i.e. quinolines
and quinazolines, are also reported.
Keywords: Nitrogenated heterocycles, pyridine, pyrimidine, biological activities, synthesis, molecular modeling.
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