Objective: Aging is a natural biological phenomenon that occurs in human beings. With increasing
of age, there is an appearance of deleterious changes related to progression onto pathological
conditions, including hypertension, heart disease, diabetes, hearing and vision impairments, as well as
sleep disorders. It is important to recognize that some sleep disturbances reported by aged subjects include
insomnia, obstructive sleep apnea, restless legs syndrome, among others. Moreover, accumulating
evidence indicates that coexistence of medical issues with sleep disorders constitutes clinical challenges
for treatment of comorbidities in elderly. Here, we have attempted to review and summarize the available
literature that assesses the sleep disturbances in aging. In addition, we highlight the management of
sleep disorders associated with aging. Due to the particular health condition of aged adults, the development
of effective pharmacological interventions for sleep disorders treatment in aging is warranted.
Methods: Review of studies retrieved from the PubMed.
Results: The sleep-wake cycle includes abnormalities classified as sleep disorders. Comorbidity between
sleep disturbances and aging-related health issues will represent a public health challenge to be
addressed in the near future. Moreover, this scenario will suggest an area that requires further drug investigation
and design of new pharmacological and pharmaceutical strategies to treat sleep disorders in
the elderly population.
Conclusion: The review highlights the sleep disturbances in aging. We focus on current knowledge in
medicinal chemistry and further design of new treatments tools for managing sleep disturbances in the