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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Hypothesis

Is there a Role for Sodium Orthovanadate in the Treatment of Diabetes?

Author(s): Divya Rana and Anoop Kumar*

Volume 15, Issue 4, 2019

Page: [284 - 287] Pages: 4

DOI: 10.2174/1573399814666180903162556

Price: $65

Abstract

Background: Diabetes is a metabolic disorder, whose incidences are increasing day by day. Various classes of anti-diabetic drugs are clinically approved by the Food and Drug Administration (FDA) for the treatment of diabetes mellitus, but unfortunately, none of them is able to treat this condition. Thus, the exploration of novel mechanistic pathways of existing molecules may help to develop more safe and effective anti-diabetic agents. Sodium orthovanadate is a well known common laboratory agent used to preserve the protein tyrosyl phosphorylation state of the protein.

Methods: The data related to sodium orthovanadate and diabetes mellitus has been collected from Pubmed.

Results: Various reports have indicated the potential of sodium orthovanadate as Protein Tyrosine Phosphatase (PTP1B) inhibitors which play an important role in the pathogenesis of diabetes. However, safety of Sodium orthovanadate is still questionable.

Conclusion: The sodium orthovanadate could be developed as an anti-diabetic agent. However, further studies are required to confirm its safety profile in the treatment of diabetes mellitus before starting a clinical trial.

Keywords: Diabetes mellitus, sodium orthovanadate, PTP1B, phosphorylation, safety, efficacy.

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