Investigation of the Inhibitory Effects of Human Carbonic Anhydrase I and Jack Bean Urease by Coumarin Derivates

Author(s): Imdat Aygul , Fatma Yaylaci Karahalil* , Ozkan Danis , Ayşe Ogan , Sevgi Kolayli .

Journal Name: Current Enzyme Inhibition

Volume 14 , Issue 3 , 2018

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Abstract:

Introduction: This study investigated the in vitro inhibition properties of newly synthesized coumarin derivates (C1-C5) against human carbonic anhdyrase I (hCA-I) and jack bean urease. Activities were expressed as IC50 (mg/mL), the concentration reducing 50% of the enzymes. The IC50 values for hCA-I ranged 5.20 µM from 12.10 µM, with compound C3 exhibiting the highest activity. The inhibition values for urease ranged 22.30 µM to 39.00 µM, the highest activity being observed in C5.

Conclusion: Comparing the inhibitions with standard inhibitors of the enzymes, while the samples exhibited moderate inhibitions against hCA I, high inhibition was determined against urease.

Keywords: Carbonic anhydrase, coumarin, inhibition, jack bean, synthesis compounds, urease.

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2018
Page: [226 - 232]
Pages: 7
DOI: 10.2174/1573408014666180903143132
Price: $58

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