Abstract
A group of stimulus-responsive biopolymers developed from the hydrophobic domain of tropoelastin is collectively known as elastin-like polypeptides (ELPs). These peptides generally consist of repeated pentapeptide units of the form (VPGXG)n, where X can be any amino acid with the exception of proline. ELPs present wide-ranging possibilities in biomedicine due to their many beneficial characteristics, including tunable phase transition behavior and biological compatibility, along with the absence of immunogenic and pyrogenic characteristics. The present paper reviews the physicochemical characteristics of ELPs and outlines a range of applications in biotechnology and medicine.
Keywords: Elastin-like polypeptides, inverse temperature phase transition, drug delivery, protein purification, tissue engineering, endoscopic submucosal injection solution.
Current Pharmaceutical Design
Title:Protein-derived Smart Materials for Medical Applications: Elastin-like Polypeptides
Volume: 24 Issue: 26
Author(s): Rui Lin*, Shanshan Wang and Wentian Liu
Affiliation:
- Department of Gastroenterology and Hepatology, Tianjin Medical University, General Hospital, Tianjin 300052,China
Keywords: Elastin-like polypeptides, inverse temperature phase transition, drug delivery, protein purification, tissue engineering, endoscopic submucosal injection solution.
Abstract: A group of stimulus-responsive biopolymers developed from the hydrophobic domain of tropoelastin is collectively known as elastin-like polypeptides (ELPs). These peptides generally consist of repeated pentapeptide units of the form (VPGXG)n, where X can be any amino acid with the exception of proline. ELPs present wide-ranging possibilities in biomedicine due to their many beneficial characteristics, including tunable phase transition behavior and biological compatibility, along with the absence of immunogenic and pyrogenic characteristics. The present paper reviews the physicochemical characteristics of ELPs and outlines a range of applications in biotechnology and medicine.
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Cite this article as:
Lin Rui *, Wang Shanshan and Liu Wentian , Protein-derived Smart Materials for Medical Applications: Elastin-like Polypeptides, Current Pharmaceutical Design 2018; 24 (26) . https://dx.doi.org/10.2174/1381612824666180903122432
DOI https://dx.doi.org/10.2174/1381612824666180903122432 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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