A group of stimulus-responsive biopolymers developed from the hydrophobic domain of tropoelastin
is collectively known as elastin-like polypeptides (ELPs). These peptides generally consist of repeated pentapeptide
units of the form (VPGXG)n, where X can be any amino acid with the exception of proline. ELPs present
wide-ranging possibilities in biomedicine due to their many beneficial characteristics, including tunable phase
transition behavior and biological compatibility, along with the absence of immunogenic and pyrogenic characteristics.
The present paper reviews the physicochemical characteristics of ELPs and outlines a range of applications
in biotechnology and medicine.
Keywords: Elastin-like polypeptides, inverse temperature phase transition, drug delivery, protein purification, tissue engineering, endoscopic
submucosal injection solution.
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