Title:The Mechanism of Exosomes Function in Neurological Diseases: A Progressive Review
VOLUME: 24 ISSUE: 24
Author(s):Mengchen Yuan, Nan Liu, Xiaofeng Wang, Chao Tian, Xiaomeng Ren, Hanlai Zhang, Xinyu Yang, Xinye Li, Haiyan Zhu, Lingqun Zhu, Hongcai Shang, Yanwei Xing* and Yonghong Gao*
Affiliation:Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Department of Neurology, Military General Hospital of Beijing PLA, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, Guang'an men Hospital, Chinese Academy of Chinese Medical Sciences, Beijing 100053, Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700
Keywords:Exosomes, neurological diseases, biomarkers, angiogenesis, neurogenesis, blood brain barrier.
Abstract:Exosomes are extracellular microparticles (≈30–100 nm in diameter) secreted from nearly all types of
cells, containing a whole set of biological information including proteins, ribonucleic acid (RNA) and lipids.
Latest studies show that exosomes contribute to cell-cell communication and are considered closely related with
the modulation of angiogenesis and neurogenesis in many neurological diseases. In the past decade, numerous
researchers were devoted to exosomes study, but the mechanism of exosomes function and delivery is uncertain.
In this review, we summarized several potential mechanisms of exosomes function in angiogenesis, neurogenesis
and Blood Brain Barrier (BBB) delivery, and differentiate various sources of exosomes in stroke, tumor, Traumatic
Brain Injury (TBI) and Alzheimer's Disease (AD) aimed to report the most advanced mechanical theories in
related past three years to provide a new sight for this research area.
