Sulphur mustard (SM; (2, 2'-dichloroethylsulfide)) was used for the first time in 1917, during the
World War I. SM mainly induces DNA damage, oxidative stress, and inflammation. This compound injures the
respiratory system, eyes, skin and the endocrine, gastrointestinal, and hematopoietic systems. However, due to the
high lipophilicity of the SM and the lipophilic nature of the tear film, and also due to the direct contact of the eyes
with the environment, the eyes are the most vulnerable part of the body to SM. SM causes several proteomic
alterations in the eye. It increases the production and activity of inflammatory proteins, reduces the concentration
of antioxidant proteins and activates the proteins involved in the onset of apoptosis. In this study, we reviewed
SM-related proteomic alterations and the association of the found proteins with other eye disorders and diseases.
Furthermore, using pathway enrichment analysis, we found the most central biological processes involved in the
emergence of complications caused by SM. Our results revealed that deficient cellular homeostasis, especially in
terms of iron-dependent regulations, as well as pathological changes in vascular endothelial growth factor
(VEGF) expression, is the most central biological process involved in eye injuries caused by SM.