Abstract
Background: Stellera chamaejasme is a perennial weed and is found across a wide geographic range. It is found in the Altai of eastern Russia, northern China and Mongolia southwards and reaches as far as the western Himalayas of the Qinghai-Tibet and Yungui Plateaus. The dried roots of S. Chamaejasme are named “Rui- Xiang-Lang-Du” and this herb with toxic properties is widely used in Traditional Chinese Medicine for the treatment of various disorders. It is effective against dispelling phlegm by water and displays toxicity against insect pests. This review provides a comprehensive overview of the chemical composition and the pharmacological properties of S. Chamaejasme thus providing a better insight into its application in the prevention of human disease.
Methods: A comprehensive literature review was undertaken and the main chemical compounds found in S. Chamaejasme were identified on the basis of their chemical formula and structure. These included flavonoids, coumarins, lignans, diterpenoids plus others, and their pharmacological properties were also summarized in detail.
Results: The main constituents of S. Chamaejasme included flavonoids, coumarins, lignans, diterpenoids plus other compounds. The pharmacological properties of these compounds displayed a wide spectrum and include anti-tumors, anti-viral, anti-bacterial, anti-convulsive, anti-epileptic, insecticide, anti-inflammation, regulation of immunity etc. The diterpenoids were widely recognized as the constituent responsible for the anti-tumor effect.
Conclusion: A large number of studies conclude that S. Chamaejasme displays a wide spectrum of pharmacological activity with the anti-tumor activity being significant.
Keywords: Stellera chamaejasme, chinese herbal medicine, chemical compositions, analytical method, pharmacological activities, toxicity.
Current Pharmaceutical Design
Title:Chemical Constituents and Pharmacological Activities of Stellera chamaejasme
Volume: 24 Issue: 24
Author(s): Xiao-Qin Li, Khalid Rahman, Jian-Yong Zhu*Hong Zhang*
Affiliation:
- Central Laboratory, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai,China
- Central Laboratory, Seventh People's Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai,China
Keywords: Stellera chamaejasme, chinese herbal medicine, chemical compositions, analytical method, pharmacological activities, toxicity.
Abstract: Background: Stellera chamaejasme is a perennial weed and is found across a wide geographic range. It is found in the Altai of eastern Russia, northern China and Mongolia southwards and reaches as far as the western Himalayas of the Qinghai-Tibet and Yungui Plateaus. The dried roots of S. Chamaejasme are named “Rui- Xiang-Lang-Du” and this herb with toxic properties is widely used in Traditional Chinese Medicine for the treatment of various disorders. It is effective against dispelling phlegm by water and displays toxicity against insect pests. This review provides a comprehensive overview of the chemical composition and the pharmacological properties of S. Chamaejasme thus providing a better insight into its application in the prevention of human disease.
Methods: A comprehensive literature review was undertaken and the main chemical compounds found in S. Chamaejasme were identified on the basis of their chemical formula and structure. These included flavonoids, coumarins, lignans, diterpenoids plus others, and their pharmacological properties were also summarized in detail.
Results: The main constituents of S. Chamaejasme included flavonoids, coumarins, lignans, diterpenoids plus other compounds. The pharmacological properties of these compounds displayed a wide spectrum and include anti-tumors, anti-viral, anti-bacterial, anti-convulsive, anti-epileptic, insecticide, anti-inflammation, regulation of immunity etc. The diterpenoids were widely recognized as the constituent responsible for the anti-tumor effect.
Conclusion: A large number of studies conclude that S. Chamaejasme displays a wide spectrum of pharmacological activity with the anti-tumor activity being significant.
Export Options
About this article
Cite this article as:
Li Xiao-Qin , Rahman Khalid , Zhu Jian-Yong *, Zhang Hong*, Chemical Constituents and Pharmacological Activities of Stellera chamaejasme, Current Pharmaceutical Design 2018; 24 (24) . https://dx.doi.org/10.2174/1381612824666180903110802
DOI https://dx.doi.org/10.2174/1381612824666180903110802 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
Call for Papers in Thematic Issues
"Tuberculosis Prevention, Diagnosis and Drug Discovery"
The Nobel Prize-winning discoveries of Mycobacterium tuberculosis and streptomycin have enabled an appropriate diagnosis and an effective treatment of tuberculosis (TB). Since then, many newer diagnosis methods and drugs have been saving millions of lives. Despite advances in the past, TB is still a leading cause of infectious disease mortality ...read more
Current Pharmaceutical challenges in the treatment and diagnosis of neurological dysfunctions
Neurological dysfunctions (MND, ALS, MS, PD, AD, HD, ALS, Autism, OCD etc..) present significant challenges in both diagnosis and treatment, often necessitating innovative approaches and therapeutic interventions. This thematic issue aims to explore the current pharmaceutical landscape surrounding neurological disorders, shedding light on the challenges faced by researchers, clinicians, and ...read more
Emerging and re-emerging diseases
Faced with a possible endemic situation of COVID-19, the world has experienced two important phenomena, the emergence of new infectious diseases and/or the resurgence of previously eradicated infectious diseases. Furthermore, the geographic distribution of such diseases has also undergone changes. This context, in turn, may have a strong relationship with ...read more
Melanoma and Non-Melanoma Skin Cancer Treatment: Standard of Care and Recent Advances
In this thematic issue, we aim to provide a standard of care of the diagnosis and treatment of melanoma and non-melanoma skin cancer. The editor will invite authors from different countries who will write review articles of melanoma and non-melanoma skin cancers. The Diagnosis, Staging, Surgical Treatment, Non-Surgical Treatment all ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Cancer Immunotherapy - Immune Checkpoint Inhibitors in Hepatocellular Carcinoma
Recent Patents on Anti-Cancer Drug Discovery Prospective Teratology of Retinoic Acid Metabolic Blocking Agents (RAMBAs) and Loss of CYP26 Activity
Current Pharmaceutical Design Bioengineering RNA Silencing Across the Life Kingdoms
Recent Patents on Biotechnology Intercellular Crosstalk Via Extracellular Vesicles in Tumor Milieu as Emerging Therapies for Cancer Progression
Current Pharmaceutical Design Editorial [Hot Topic: Prospective Clinical Role for Anticancer Garlic Organosulfur Compounds (Guest Editor: Hassan T. Hassan)]
Anti-Cancer Agents in Medicinal Chemistry Toxicities of Immunosuppressive Treatment of Autoimmune Neurologic Diseases
Current Neuropharmacology Advances in Antioxidative Therapy of Multiple Sclerosis
Current Medicinal Chemistry Plasticity and Maintenance of Hematopoietic Stem Cells During Development
Recent Patents on Biotechnology Platinum-Based Agents for Individualized Cancer Treatment
Current Molecular Medicine Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
Current Pharmaceutical Biotechnology Potential Beneficial Effects of Garlic in Oncohematology
Mini-Reviews in Medicinal Chemistry Phytoconstituents of <i>Lantana camara</i> L.: Rekindling Hope in the Cancer Treatment
Current Bioactive Compounds Innovative Cell Therapy in the Treatment of Serious Adverse Events Related to Both Chemo-Radiotherapy Protocol and Acute Myeloid Leukemia Syndrome: The Infusion of Mesenchymal Stem Cells Post-Treatment Reduces Hematopoietic Toxicity and Promotes Hematopoietic Reconstitution
Current Pharmaceutical Biotechnology Cytokine/Antibody Complexes: An Emerging Class of Immunostimulants
Current Pharmaceutical Design The Role of Aryl Hydrocarbon Receptor-Regulated Cytochrome P450 Enzymes in Glioma
Current Pharmaceutical Design A Review of Natural and Synthetic Antioxidants Important for Health and Longevity
Current Medicinal Chemistry Look Into My Onco-forest - Review of Plant Natural Products with Anticancer Activity
Current Topics in Medicinal Chemistry Follicular Immunology Environment and the Influence on In Vitro Fertilization Outcome
Current Women`s Health Reviews Biotransformation of Microcystins in Eukaryotic Cells - Possible Future Research Directions
Mini-Reviews in Medicinal Chemistry Helper T Cells Point the Way to Specific Immunotherapy for Autoimmune Disease
Cardiovascular & Hematological Disorders-Drug Targets