Fructose-1,6-bisphosphatase Inhibitors: A Review of Recent (2000– 2017) Advances and Structure-Activity Relationship Studies

(E-pub Ahead of Print)

Author(s): Sarbjit Singh, Dipesh S. Harmalkar , Yongseok Choi*, Kyeong Lee*.

Journal Name: Current Medicinal Chemistry

Submit Manuscript
Submit Proposal


Diabetes mellitus, commonly referred to as diabetes, is the 8th leading cause of death worldwide. As of 2015, approximately 415 million people were estimated to be diabetic worldwide, type 2 diabetes being the most common accounting for approximately 90–95% of all diagnosed cases with increasing prevalence. Fructose-1,6-bisphosphatase is one of the important therapeutic targets recently discovered to treat this chronic disease. In this focused review, we have highlighted recent advances and structure-activity relationship studies in the discovery and development of different fructose-1,6-bisphosphatase inhibitors reported since the year 2000.

Keywords: Fructose-1, 6-bisphosphatase Inhibitors, Type 2 diabetes, Adenosine 5’-monophosphate, Hyperglycemia, Diabetes mellitus.

Rights & PermissionsPrintExport Cite as

Article Details

(E-pub Ahead of Print)
DOI: 10.2174/0929867325666180831133734
Price: $95

Article Metrics

PDF: 4