Fructose-1,6-bisphosphatase Inhibitors: A Review of Recent (2000– 2017) Advances and Structure-Activity Relationship Studies

(E-pub Ahead of Print)

Author(s): Sarbjit Singh, Dipesh S. Harmalkar , Yongseok Choi*, Kyeong Lee*.

Journal Name: Current Medicinal Chemistry

Submit Manuscript
Submit Proposal

Abstract:

Diabetes mellitus, commonly referred to as diabetes, is the 8th leading cause of death worldwide. As of 2015, approximately 415 million people were estimated to be diabetic worldwide, type 2 diabetes being the most common accounting for approximately 90–95% of all diagnosed cases with increasing prevalence. Fructose-1,6-bisphosphatase is one of the important therapeutic targets recently discovered to treat this chronic disease. In this focused review, we have highlighted recent advances and structure-activity relationship studies in the discovery and development of different fructose-1,6-bisphosphatase inhibitors reported since the year 2000.

Keywords: Fructose-1, 6-bisphosphatase Inhibitors, Type 2 diabetes, Adenosine 5’-monophosphate, Hyperglycemia, Diabetes mellitus.

Rights & PermissionsPrintExport Cite as


Article Details

(E-pub Ahead of Print)
DOI: 10.2174/0929867325666180831133734
Price: $95

Article Metrics

PDF: 4