Background: Heart injury is one of the most important concerns after exposure to a high
dose of radiation in chest cancer radiotherapy or whole body exposure to a radiation disaster. Studies
have proposed that increased level of inflammatory and pro-fibrotic cytokines following radiotherapy
or radiation events play a key role in the development of several side effects such as cardiovascular
disorders. In the current study, we aimed to evaluate the expression of IL-4 and IL-13 cytokines as well
as signaling pathways such as IL4Ra1, IL13Ra2, Duox1 and Duox2. In addition, we detected the
possible protective effect of curcumin on the expression of these factors and infiltration of inflammatory
Materials and Methods: Twenty rats were divided into 4 groups including control; curcumin treated;
radiation; and radiation plus curcumin. After 10 weeks, rats were sacrificed for evaluation of mentioned
Results: Results showed an increase in the level of IL-4 and all evaluated genes, as well as increased
infiltration of lymphocytes and macrophages. Treatment with curcumin could attenuate these changes.
Conclusion: Curcumin could reduce radiation-induced heart injury markers in rats.