Pleiotropic Effect of Mahanine and Girinimbine Analogs: Anticancer Mechanism and its Therapeutic Versatility

Author(s): V. Lenin Maruthanila, Ramakrishnan Elancheran*, Ajaikumar B. Kunnumakkar, Senthamaraikannan Kabilan, Jibon Kotoky*.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 18 , Issue 14 , 2018

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Abstract:

Emerging evidence present credible support in favour of the potential role of mahanine and girinimbine. Non-toxic herbal carbazole alkaloids occur in the edible part of Murraya koenigii, Micromelum minutum, M. zeylanicum, and M. euchrestiolia. Mahanine and girinimbine are the major potent compounds from these species. In fact, they interfered with tumour expansion and metastasis development through down-regulation of apoptotic and antiapoptotic protein, also involved in the stimulation of cell cycle arrest. Consequently, these compounds were well proven for the in-vitro and in vivo evaluation that could be developed as novel agents either alone or as an adjuvant to conventional therapeutics. Therefore, mahanine and girinimbine analogs have the potential to be the promising chemopreventive agents for the tumour recurrence and the treatment of human malignancies. In this review, an updated wide-range of pleiotropic anticancer and biological effects induction by mahanine and girinimbine against cancer cells were deeply summarized.

Keywords: Mahanine, girinimbine, Murraya species, prevention and therapy, apoptosis, pleiotropic anticancer.

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Article Details

VOLUME: 18
ISSUE: 14
Year: 2018
Page: [1983 - 1990]
Pages: 8
DOI: 10.2174/1871520618666180830151720
Price: $58

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