Background: The problem of poor immunogenicity of new generation vaccines
has generated the need for more effective and safe adjuvants for inducing a seroprotective
Objective and Method: The plant-based immunoadjuvants have the potential to promote an
optimized immune response and are promising candidate adjuvants for novel vaccine development.
There are many natural compounds, which exhibit vaccine adjuvant activity. However,
safety and hemolytic toxicity remain a problem. Research in the last four decades
shows that plant extracts can be screened for isolating the least toxic adjuvant. Plant-based
adjuvants with their superior immunostimulatory property could provide us with an effective
alternative to conventional adjuvants.
Conclusion: The present paper enumerates the plant-based immunoadjuvant which has
shown remarkable immunostimulatory properties.
Keywords: Haemolytic, immunoadjuvant, ovalbumin, polysaccharide, saponins, splenocyte.
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