Recent Finding in Repair of the Peripheral Nerve Lesions Using Pharmacological Agents: Common Methods for Evaluating the Repair Process

Title:Recent Finding in Repair of the Peripheral Nerve Lesions Using Pharmacological Agents: Common Methods for Evaluating the Repair Process

Volume: 18 Issue: 3

Author(s): Dheyauldeen Shabeeb, Masoud Najafi, Mansor Keshavarz, Ahmed Eleojo Musa, Gholamreza Hassanzadeh, Mohammed Reza Hadian and Alireza Shirazi*

Affiliation:

• Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Science, Tehran,Iran

Keywords: Biochemical, electrophysiological, functional evaluation, histo-morphological, peripheral nerve injury, peripheral nerve, pharmaceutical agents.

Abstract: Introduction: Peripheral nerve lesion is a common clinical problem that may produce longterm functional defects. Usually, crush injuries, fractures, scars, lacerations, compression, or iatrogenic reasons are reasons for nerve injuries. Unsuccessful treatment of nerve injuries causes partial or total loss of sense, motor, and autonomic functions. Despite widespread experimental studies that aimed to improve nerve healing, healing results for peripheral nerve injuries are hardly reasonable. The successes of the regenerative procedure of the nerve repair in experimental research, with topical agents, can be assessed using different methods such as morphological, electrophysiological, biochemical and functional evaluation. Although, most researchers confirm that despite good microsurgical repair and topical application of these substances, complete regeneration and functional recovery of the injured nerves are almost never achieved.

Conclusion: This study aimed to make a comparison between topical pharmacological agents at the peripheral nerve lesion and methods used for evaluating the success of the repair process. For this purpose, we reviewed studies conducted on some of the most commonly used pharmacological agents as well as their properties in the repair of peripheral nerve lesions.

Cite this article as:

Shabeeb Dheyauldeen , Najafi Masoud , Keshavarz Mansor , Musa Eleojo Ahmed , Hassanzadeh Gholamreza , Hadian Reza Mohammed and Shirazi Alireza *, Recent Finding in Repair of the Peripheral Nerve Lesions Using Pharmacological Agents: Common Methods for Evaluating the Repair Process, Central Nervous System Agents in Medicinal Chemistry 2018; 18 (3) . https://dx.doi.org/10.2174/1871524918666180830101953