Background: A novel strategy has been adapted to combat the threat caused by biofilm
forming-pathogenic bacteria in our environments. It involves the synthesis of antibiofilm compounds
biologically (metabolites from animals, microbes and plants) and chemically. As a result of extensive
research, a significant number of antimicrobial compounds and biofilm inhibitors have been isolated
and characterized from different biological and chemical sources. However, lots of limitations such as
poor delivery, water-insolubility, stability, expulsion by efflux pumps, and the development of acquired
resistance due to long-term exposure have been associated with these compounds.
Methods: Conjugation or encapsulation of these antibiofilm drugs with different biocompatible, biodegradable,
chemically and thermally stable nanomaterials results in enhanced efficiency of biofilm
Results and Conclusion: This review article evaluates the current impact of antibiofilm drugs including
its delivery, efficiency of blocking cell attachment and molecular mechanisms of action that is conjugated
or encapsulated with different types of biocompatible nanomaterials. It will lead to a better understanding
of the antibiofilm drugs and their role in combating biofilms. It will also open new doors
for the application of immobilized antibiofilm drugs.