Synthesis, Antioxidant and Antiurease Activities of Some New 5,6- dichloro-2-(4-fluorobenzyl)-1H-benzimidazole Derivatives Containing Furan, Oxadiazole, Triazole and Thiadiazole Moieties

Author(s): Hakan Bektas*, Canan Albay, Emre Menteşe, Bahar Bilgin Sokmen, Zafer Kurt, Dilem Şen.

Journal Name: Letters in Drug Design & Discovery

Volume 16 , Issue 8 , 2019

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Graphical Abstract:


Abstract:

Background: Benzimidazoles and its derivatives have been attracting interest for many years because of their biological activities. Benzimidazoles containing different heterocyclic moieties have wide range of biological activities such as antimicrobial, antioxidant, anticancer, antiviral, etc.

Methods: In this study, some benzimidazole derivatives containing furan, oxadiazole, triazole and thiadiazole moieties have been synthesized and then evaluated for their antioxidant and antiurease activities.

Results: The results showed that all the tested benzimidazoles indicated remarkable urease inhibitory potentials with IC50 values ranging between 0.303±0.03 to 0.591±0.08 µM.

Conclusion: In conclusion, synthesized benzimidazole derivatives showed good antioxidant and antiurease activities. Heterocyclic groups on benzimidazole nucleus enhance the activities.

Keywords: Antioxidant, antiurease, benzimidazole, 1, 3, 4-oxadiazole, 1, 2, 4-triazole, 1, 3, 4-thiadiazole.

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2019
Page: [939 - 947]
Pages: 9
DOI: 10.2174/1570180815666180827124956
Price: $65

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