Background: Thiazole is widely investigated bioactive scaffold and dynamic tool in medicinal
chemistry research. Significance of thiazole compounds are well documented as thiazole is an
obligatory structure of number of currently available therapeutics. In spite of that, thiazole derivatives
are endowed with myriad biological activities, such as antiviral, anticancer, antibacterial, antifungal,
antimalarial, antiparkinsonian, anti-inflammatory activities and many more.
Methods: In recent past, different approaches have been introduced for synthesis of thiazole and related
compounds. Intrinsic molecular interaction between newly synthesized thiazole compounds and plethora
of drug targets/enzymes has rendered discovery of new drug molecules with advances in modes of
action. A renewed interest in therapeutic use of thiazole derivatives has been seen among the prospective
researchers as exemplified by influx of huge scientific articles and patents. Some important patents
of anti-infective and anticancer interest have been addressed appropriately and are presented in tables.
Results: This review paper is a contemporary approach on therapeutic/applications of thiazole derivatives
by summarizing important patents filed from 2000-2017. The main focus of these patents is on
anti-infective and anticancer potential of thiazole based compounds.
Conclusion: These approaches may provide valuable information for the further design of more active
biological agents through various modifications and derivatizations.