Targeting Breast Cancer Stem Cells: A Methodological Perspective

Author(s): Marco A. Velasco-Velázquez*, Inés Velázquez-Quesada, Luz X. Vásquez-Bochm, Sonia M. Pérez-Tapia.

Journal Name: Current Stem Cell Research & Therapy

Volume 14 , Issue 5 , 2019

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Abstract:

Cancer Stem Cells (CSCs) constitute a subpopulation at the top of the tumor cell hierarchy that contributes to tumor heterogeneity and is uniquely capable of seeding new tumors. Because of their biological properties, CSCs have been pointed out as therapeutic targets for the development of new therapies against breast cancer. The identification of drugs that selectively target breast CSCs requires a clear understanding of their biological functions and the experimental methods to evaluate such hallmarks. Herein, we review the methods to study breast CSCs properties and discuss their value in the preclinical evaluation of CSC-targeting drugs.

Keywords: Cancer stem cells, anticancer drugs, self-renewal, CSC selective toxicity, CSC differentiation, breast tumors.

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VOLUME: 14
ISSUE: 5
Year: 2019
Page: [389 - 397]
Pages: 9
DOI: 10.2174/1574888X13666180821155701
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