Introduction: Transferosomes also known as ultra-deformable liposomes were introduced by
Gregor Cevc in 1990. These are deformable vesicles that transport drug across the skin, which is the best
route of drug delivery because skin is the largest human organ with 3 kg total weight and a surface area
of 1.5-2.0 m2.
Methods: Transferosomes are able to efficiently deliver low as well as high molecular weight drug
across the skin in terms of quantity and depth. Various methods used for the preparation of transferosomes
such as thin film hydration method, reverse phase evaporation method, vortex/sonication
method, ethanol injection method and freeze thaw method.
Results: The prepared transferosomal preparation will be evaluated for particle shape and size, entrapment
efficiency, stability study, penetration ability and skin permeation study. In vitro release studies are
to be performed using a specific dissolution medium.
Conclusion: Ultra deformable liposomes can be used for delivery of different drugs e.g. analgesic, anesthetic,
corticosteroids, anticancer, sex hormone, insulin, gap junction protein, and albumin.