Ultra-deformable Liposomes as Flexible Nanovesicular Carrier to Penetrate Versatile Drugs Transdermally

Author(s): Gaurav Tiwari*, Ruchi Tiwari, Rachna Singh, Awani K. Rai.

Journal Name: Nanoscience & Nanotechnology-Asia

Volume 10 , Issue 1 , 2020

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Graphical Abstract:


Introduction: Transferosomes also known as ultra-deformable liposomes were introduced by Gregor Cevc in 1990. These are deformable vesicles that transport drug across the skin, which is the best route of drug delivery because skin is the largest human organ with 3 kg total weight and a surface area of 1.5-2.0 m2.

Methods: Transferosomes are able to efficiently deliver low as well as high molecular weight drug across the skin in terms of quantity and depth. Various methods used for the preparation of transferosomes such as thin film hydration method, reverse phase evaporation method, vortex/sonication method, ethanol injection method and freeze thaw method.

Results: The prepared transferosomal preparation will be evaluated for particle shape and size, entrapment efficiency, stability study, penetration ability and skin permeation study. In vitro release studies are to be performed using a specific dissolution medium.

Conclusion: Ultra deformable liposomes can be used for delivery of different drugs e.g. analgesic, anesthetic, corticosteroids, anticancer, sex hormone, insulin, gap junction protein, and albumin.

Keywords: Ultra-deformable liposomes, transferosomes, nanovesicular carrier, entrapment efficiency, penetration ability, skin permeation.

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Article Details

Year: 2020
Page: [12 - 20]
Pages: 9
DOI: 10.2174/2210681208666180820145327
Price: $25

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PDF: 9