Background: Cerebral ischemia is a common cause of disability and death. Ischemic brain injury results
from complex pathological processes, including oxidative stress, inflammation, and apoptosis. Thioredoxin(
Trx) is an important multifunctional protein, which regulates cellular redox status. Increasing studies have
demonstrated that Trx provides a neuroprotective role against cerebral ischemia-induced injury.
Methods: A systematic search of PMC and the PubMed Database was conducted to summarize the protective
effects of Trx against cerebral ischemia.
Results: This article reviews the understanding of potential effects and mechanisms of Trx against cerebral
ischemia, including the anti-oxidant, anti-apoptotic and anti-inflammatory effects, as well as the activation of prosurvival
pathway. We also summarize that some natural compounds induce the expression of Trx, which is involved
in their anti-ischemic effects.
Conclusion: In conclusion, Trx has a potential neuroprotection in cerebral ischemia and may be very promising
for clinical therapy of ischemic stroke in the future.