Clopidogrel Hypersensitivity: Overview of the Problem

Author(s): Michael P. Savage , David L. Fischman .

Journal Name: Current Vascular Pharmacology

Volume 17 , Issue 2 , 2019

Become EABM
Become Reviewer

[1]
Campbell KL, Cohn JR, Savage MP. Clopidogrel hypersensitivity: Clinical challenges and options for management. Expert Rev Clin Pharmacol 2010; 3: 353-61.
[2]
Topol EJ, Schork NJ. Catapulting clopidogrel pharmacogenomics forward. Nat Med 2011; 17: 40-1.
[3]
CAPRIE Steering Committee. A randomized, blinded trial of clopidogrel versus aspirin in patients at risk of ischemic events (CAPRIE). Lancet 1996; 348: 1329-39.
[4]
Mehta SR, Yusuf S. The clopidogrel in unstable angina to prevent recurrent events trial investigators. effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 2001; 345: 494-502.
[5]
Mehta SR, Yusuf S, Peters RH, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary interventions: The PCI-CURE study. Lancet 2001; 358: 527-33.
[6]
Steinhubl SR, Berger PB, Mann JT, et al. Early and sustained dual aspirin antiplatelet therapy following percutaneous coronary intervention: A randomized controlled trial. JAMA 2002; 288: 2411-20.
[7]
Sabatine MS, Cannon CP, Gibson CM, et al. Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med 2005; 352: 1179-89.
[8]
Chen ZM, Jiang LX, Chen YP, et al. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: Randomized placebo-controlled trial. Lancet 2005; 366: 1607-21.
[9]
Bhatt DL, Fox KA, Hacke W, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med 2006; 354: 1706-17.
[10]
Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013; 369: 11-9.
[11]
Johnson SC, Easton JD, Farrant M, et al. Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA. N Engl J Med 2018; 379: 215-25.
[12]
Grines CL, Bonow RO, Casey DE, et al. Prevention of premature discontinuation of dual antiplatelet therapy in patients with coronary artery stents: A science advisory from the American heart association, American college of cardiology, society of cardiac angiography and intervention, American college of surgeons, and American dental association with representation from the American college of physicians. J Am Coll Cardiol 2007; 49: 734-9.
[13]
Jeremias A, Sylvia B, Bridges J, et al. Stent thrombosis after successful sirolimus-eluting stent implantation. Circulation 2004; 109: 1930-2.
[14]
Iakovou I, Schidt T, Bonizzoni E, et al. Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. JAMA 2005; 293: 2126-30.
[15]
Cohn JR, Savage MP. Hypersensitivity reactions to clopidogrel Up-to-date, online (Accessed on August 1, 2018)
[16]
von Tiehl KF, Price MJ, Valencia R, Ludington KJ, Teirstein PS, Simon RA. Clopidogrel desensitization after drug-eluting stent placement. J Am Coll Cardiol 2007; 50: 2030-43.
[17]
Campbell KL, Fischman DL, Savage MP, et al. Management of clopidogrel hypersensitivity without drug interruption. Am J Cardiol 2011; 58: 1445-54.
[18]
Cheema AN, Mohammad A, Hong T, et al. Characterization of clopidogrel hypersensitivity reactions and management with oral steroids without clopidogrel discontinuation. J Am Coll Cardiol 2011; 58: 1445-54.
[19]
Beavers CJ, Carris NW, Ruf KM. Management strategies for clopidogrel hypersensitivity. Drugs 2015; 75: 999-1007.
[20]
Siu H, Kaliyadan A, Fischman DL, Nardone E, Poll D, Savage MP. Use of prasugrel in the setting of clopidogrel hypersensitivity: case report and systematic review of the literature. Platelets 2016; 27: 824-7.


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 17
ISSUE: 2
Year: 2019
Page: [108 - 109]
Pages: 2
DOI: 10.2174/1570161116666180820123041

Article Metrics

PDF: 32
HTML: 1