Clopidogrel remains a widely used antiplatelet agent for patients with established or high risk
of atherothrombotic disease, particularly those treated with coronary, carotid or peripheral endovascular
stenting. Clopidogrel hypersensitivity is an uncommon but well established adverse drug reaction presenting
a challenge for patient management. The clinical presentation ranges from focal or diffuse cutaneous
manifestations in most patients to angioedema in some and a systemic immune response in rare
cases. The treatment options include drug discontinuation with or without desensitization therapy,
switching to alternate ADP receptor antagonists or administration of oral steroids while continuing
clopidogrel in patients at high risk of adverse events with clopidogrel discontinuation. In this review the
author describes the phenomenon of clopidogrel hypersensitivity, various treatment strategies.
Keywords: Clopidogrel, hypersensitivity, ADP receptor antagonist, drug allergy, adverse drug reaction, skin rash.
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