The Receptor for Advanced Glycation End Products (RAGE) is an important cell surface
receptor, which belongs to the IgG super family and is now considered as a pattern recognition receptor.
Because of its relevance in many human clinical settings, it is now pursued as a very attractive
therapeutic target. However, particular features of this receptor such as a wide repertoire of ligands
with different binding domains, the existence of many RAGE variants as well as the presence of cytoplasmatic
adaptors leading a diverse signaling, are important limitations in the search for successful
pharmacological approaches to inhibit RAGE signaling. Therefore, the present review aimed to display
the most promising approaches to inhibit RAGE signaling, and provide an up to date review of
progress in this area.
Keywords: Receptor of advanced glycation end-products, advanced glycation end-products, intracellular signaling, antagonists,
inhibitors, cytoplasmatic adaptors.
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