Mesenchymal Stem Cells, Immune Cells and Tumor Cells Crosstalk: A Sinister Triangle in the Tumor Microenvironment

Author(s): Mahboobeh Razmkhah, Shabnam Abtahi, Abbas Ghaderi*.

Journal Name: Current Stem Cell Research & Therapy

Volume 14 , Issue 1 , 2019

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Abstract:

Mesenchymal Stem Cells [MSCs] are a heterogeneous population of fibroblast-like cells which maintain self-renewability and pluripotency. Many studies have demonstrated the immunomodulatory effects of MSCs on the innate and adaptive immune cells. As a result of interactions with tumor cells, microenvironment and immune-stimulating milieu, MSCs contribute to tumor progression by several mechanisms, including sustained proliferative signal in cancer stem cells [CSCs], inhibition of tumor cell apoptosis, transition to tumor-associated fibroblasts [TAFs], promotion of angiogenesis, stimulation of epithelial-mesenchymal transition [EMT], suppression of immune responses, and consequential promotion of tumor metastasis. Here, we present an overview of the latest findings on Janusfaced roles that MSCs play in the tumor microenvironment [TME], with a concise focus on innate and adaptive immune responses.

Keywords: Mesenchymal stem cells, tumor microenvironment, immunomodulation, innate immune response, adaptive immune response, metastasis.

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Article Details

VOLUME: 14
ISSUE: 1
Year: 2019
Page: [43 - 51]
Pages: 9
DOI: 10.2174/1574888X13666180816114809
Price: $58

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