A Review on Recent Synthetic Strategies and Pharmacological Importance of 1,3-Thiazole Derivatives

Author(s): Swarnagowri Nayak, Santhosh L. Gaonkar*.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 19 , Issue 3 , 2019

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Abstract:

Thiazole is the most common heterocyclic compound in heterocyclic chemistry and in drug design. Presence of several reaction sites in the thiazole moiety extends their range of applications and leads to new solutions for challenges in synthetic and medicinal chemistry. Thiazole derivatives are widely used as bioactive agents, liquid crystals, sensors, catalysts, etc. The motivating molecular architecture of 1,3-thiazoles makes them suitable moieties for drug development. In this review, our aim is to corroborate the recent data available on various synthetic strategies and biological properties of 1,3- thiazole derivatives.

Keywords: 2-substituted thiazole, 2, 4-substituted thiazole, 2, 5-substituted thiazole, 2, 4, 5-substituted thiazole, fused thiazole, anti-microbial activity, anti-cancer activity, antioxidant activity.

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Article Details

VOLUME: 19
ISSUE: 3
Year: 2019
Page: [215 - 238]
Pages: 24
DOI: 10.2174/1389557518666180816112151
Price: $58

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