Benzamide and Benzamidine Compounds as New Inhibitors of Urokinasetype Plasminogen Activators

Title:Benzamide and Benzamidine Compounds as New Inhibitors of Urokinasetype Plasminogen Activators

Volume: 18 Issue: 20

Author(s): Canan Kuş*, Ezgi Özer, Yeşim Korkmaz, Erkan Yurtcu and Rukiye Dağalp

Affiliation:

• Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, 06100-Tandogan, Ankara,Turkey

Keywords: Imidazopyridine, benzamide, benzamidine, urinary plasminogen activator, uPAR, upamostat.

Abstract: Background & Method: In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b]pyridin-2-yl)-N-substituted benzamide and benzamidine derivatives. uPA levels obtained from 4b and 7d administration were similar to 5-FU (5-fluorouracil) for colorectal carcinoma cells (p<0.05). 4b and 7d significantly reduced uPAR (urokinase-type plasminogen activator receptor) levels on both cell lines (p<0.05).

Conclusion: uPAR levels obtaining from 4b and 7d administration were similar to 5-FU for both cell lines colorectal (Colo205, CCL-222) and hepatocellular (HepG2, CCL-23) carcinoma cells (p<0.05).

Cite this article as:

Kuş Canan *, Özer Ezgi , Korkmaz Yeşim, Yurtcu Erkan and Dağalp Rukiye , Benzamide and Benzamidine Compounds as New Inhibitors of Urokinasetype Plasminogen Activators, Mini-Reviews in Medicinal Chemistry 2018; 18 (20) . https://dx.doi.org/10.2174/1389557518666180816110740