Benzamide and Benzamidine Compounds as New Inhibitors of Urokinasetype Plasminogen Activators

Author(s): Canan Kuş*, Ezgi Özer, Yeşim Korkmaz, Erkan Yurtcu, Rukiye Dağalp.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 18 , Issue 20 , 2018

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Abstract:

Background & Method: In this ongoing research, it is aimed to investigate the synthesis, structure identification and effects on urokinase-type plasminogen activators (uPA) and its receptor levels of 4-(3H-imidazo[4,5-b]pyridin-2-yl)-N-substituted benzamide and benzamidine derivatives. uPA levels obtained from 4b and 7d administration were similar to 5-FU (5-fluorouracil) for colorectal carcinoma cells (p<0.05). 4b and 7d significantly reduced uPAR (urokinase-type plasminogen activator receptor) levels on both cell lines (p<0.05).

Conclusion: uPAR levels obtaining from 4b and 7d administration were similar to 5-FU for both cell lines colorectal (Colo205, CCL-222) and hepatocellular (HepG2, CCL-23) carcinoma cells (p<0.05).

Keywords: Imidazopyridine, benzamide, benzamidine, urinary plasminogen activator, uPAR, upamostat.

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Article Details

VOLUME: 18
ISSUE: 20
Year: 2018
Page: [1753 - 1758]
Pages: 6
DOI: 10.2174/1389557518666180816110740
Price: $58

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