Psychopharmacological Treatment of Obsessive-Compulsive Disorder (OCD)

Author(s): Antonio Del Casale* , Serena Sorice , Alessio Padovano , Maurizio Simmaco , Stefano Ferracuti , Dorian A. Lamis , Chiara Rapinesi , Gabriele Sani , Paolo Girardi , Georgios D. Kotzalidis , Maurizio Pompili .

Journal Name: Current Neuropharmacology

Volume 17 , Issue 8 , 2019

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Graphical Abstract:


Abstract:

Background: Obsessive-compulsive disorder (OCD) is associated with affective and cognitive symptoms causing personal distress and reduced global functioning. These have considerable societal costs due to healthcare service utilization.

Objective: Our aim was to assess the efficacy of pharmacological interventions in OCD and clinical guidelines, providing a comprehensive overview of this field.

Methods: We searched the PubMed database for papers dealing with drug treatment of OCD, with a specific focus on clinical guidelines, treatments with antidepressants, antipsychotics, mood stabilizers, off-label medications, and pharmacogenomics.

Results: Prolonged administration of selective serotonin reuptake inhibitors (SSRIs) is most effective. Better results can be obtained with a SSRI combined with cognitive behavioral therapy (CBT) or the similarly oriented exposure and response prevention (ERP). Refractory OCD could be treated with different strategies, including a switch to another SSRI or clomipramine, or augmentation with an atypical antipsychotic. The addition of medications other than antipsychotics or intravenous antidepressant administration needs further investigation, as the evidence is inconsistent. Pharmacogenomics and personalization of therapy could reduce treatment resistance.

Conclusions: SSRI/clomipramine in combination with CBT/ERP is associated with the optimal response compared to each treatment alone or to other treatments. New strategies for refractory OCD are needed. The role of pharmacogenomics could become preponderant in the coming years.

Keywords: Obsessive compulsive disorder, psychopharmacology, pharmacogenomics, selective serotonin reuptake inhibitors, atypical antipsychotics, off-label treatments.

[1]
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (DSM-5); American Psychiatric Association: Arlington, VA, 2013.
[2]
Rasmussen, S.A.; Eisen, J.L. The epidemiology and differential diagnosis of obsessive compulsive disorder. J. Clin. Psychiatry, 1994, 55(Suppl.), 5-10. [PMID: 7961532].
[3]
Ruscio, A.M.; Stein, D.J.; Chiu, W.T.; Kessler, R.C. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol. Psychiatry, 2010, 15(1), 53-63. [http://dx.doi.org/10.1038/mp.2008.94]. [PMID: 18725912].
[4]
Kessler, R.C.; Berglund, P.; Demler, O.; Jin, R.; Merikangas, K.R.; Walters, E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry, 2005, 62(6), 593-602. [http://dx.doi. org/10.1001/archpsyc.62.6.593]. [PMID: 15939837].
[5]
Geller, D.A.; Biederman, J.; Jones, J.; Shapiro, S.; Schwartz, S.; Park, K.S. Obsessive-compulsive disorder in children and adolescents: a review. Harv. Rev. Psychiatry, 1998, 5(5), 260-273. [http://dx.doi.org/10.3109/10673229809000309]. [PMID: 9493948].
[6]
Geller, D.A. Obsessive-compulsive and spectrum disorders in children and adolescents. Psychiatr. Clin. North Am., 2006, 29(2), 353-370. [http://dx.doi.org/10.1016/j.psc.2006.02.012]. [PMID: 16650713].
[7]
Heyman, I.; Fombonne, E.; Simmons, H.; Ford, T.; Meltzer, H.; Goodman, R. Prevalence of obsessive-compulsive disorder in the British nationwide survey of child mental health. Int. Rev. Psychiatry, 2003, 15(1-2), 178-184. [http://dx.doi.org/10.1080/0954026021 000046146]. [PMID: 12745330].
[8]
Anholt, G.E.; Aderka, I.M.; van Balkom, A.J.; Smit, J.H.; Schruers, K.; van der Wee, N.J.; Eikelenboom, M.; De Luca, V.; van Oppen, P. Age of onset in obsessive-compulsive disorder: admixture analysis with a large sample. Psychol. Med., 2014, 44(1), 185-194. [http:// dx.doi.org/10.1017/S0033291713000470]. [PMID: 23517651].
[9]
Mataix-Cols, D.; Marks, I.M.; Greist, J.H.; Kobak, K.A.; Baer, L. Obsessive-compulsive symptom dimensions as predictors of compliance with and response to behaviour therapy: results from a controlled trial. Psychother. Psychosom., 2002, 71(5), 255-262. [http:// dx.doi.org/10.1159/000064812]. [PMID: 12207105].
[10]
Stewart, S.E.; Geller, D.A.; Jenike, M.; Pauls, D.; Shaw, D.; Mullin, B.; Faraone, S.V. Long-term outcome of pediatric obsessive-compulsive disorder: a meta-analysis and qualitative review of the literature. Acta Psychiatr. Scand., 2004, 110(1), 4-13. [http://dx. doi.org/10.1111/j.1600-0447.2004.00302.x]. [PMID: 15180774].
[11]
World Health Organization (WHO). The Global Burden of Disease: 2004 Update; World Health Organization: Geneva, Switzerland, 2008.
[12]
Hirschtritt, M.E.; Bloch, M.H.; Mathews, C.A. Obsessive-compulsive disorder: Advances in diagnosis and treatment. JAMA, 2017, 317(13), 1358-1367. [http://dx.doi.org/10.1001/jama.2017.2200]. [PMID: 28384832].
[13]
Leon, A.C.; Olfson, M.; Broadhead, W.E.; Barrett, J.E.; Blacklow, R.S.; Keller, M.B.; Higgins, E.S.; Weissman, M.M. Prevalence of mental disorders in primary care. Implications for screening. Arch. Fam. Med., 1995, 4(10), 857-861. [http://dx.doi.org/10.1001/ archfami.4.10.857]. [PMID: 7551133].
[14]
Veldhuis, J.; Dieleman, J.P.; Wohlfarth, T.; Storosum, J.G.; van Den Brink, W.; Sturkenboom, M.C.; Denys, D. Incidence and prevalence of “diagnosed OCD” in a primary care, treatment seeking, population. Int. J. Psychiatry Clin. Pract., 2012, 16(2), 85-92. [http:// dx.doi.org/10.3109/13651501.2011.617454]. [PMID: 22122660].
[15]
Glazier, K.; Calixte, R.M.; Rothschild, R.; Pinto, A. High rates of OCD symptom misidentification by mental health professionals. Ann. Clin. Psychiatry, 2013, 25(3), 201-209. [PMID: 23926575].
[16]
Dell’Osso, B.; Camuri, G.; Benatti, B.; Buoli, M.; Altamura, A.C. Differences in latency to first pharmacological treatment (duration of untreated illness) in anxiety disorders: a study on patients with panic disorder, generalized anxiety disorder and obsessive-compulsive disorder. Early Interv. Psychiatry, 2013, 7(4), 374-380. [http://dx.doi.org/10.1111/eip.12016]. [PMID: 23347385].
[17]
Altamura, A.C.; Buoli, M.; Albano, A.; Dell’Osso, B. Age at onset and latency to treatment (duration of untreated illness) in patients with mood and anxiety disorders: a naturalistic study. Int. Clin. Psychopharmacol., 2010, 25(3), 172-179. [http://dx.doi.org/10. 1097/YIC.0b013e3283384c74]. [PMID: 20305566].
[18]
Torres, A.R.; Prince, M.J.; Bebbington, P.E.; Bhugra, D.K.; Brugha, T.S.; Farrell, M.; Jenkins, R.; Lewis, G.; Meltzer, H.; Singleton, N. Treatment seeking by individuals with obsessive-compulsive disorder from the british psychiatric morbidity survey of 2000. Psychiatr. Serv., 2007, 58(7), 977-982. [http://dx.doi.org/ 10.1176/ps.2007.58.7.977]. [PMID: 17602015].
[19]
Torres, A.R.; Prince, M.J.; Bebbington, P.E.; Bhugra, D.; Brugha, T.S.; Farrell, M.; Jenkins, R.; Lewis, G.; Meltzer, H.; Singleton, N. Obsessive-compulsive disorder: prevalence, comorbidity, impact, and help-seeking in the British National Psychiatric Morbidity Survey of 2000. Am. J. Psychiatry, 2006, 163(11), 1978-1985. [http://dx. doi.org/10.1176/ajp.2006.163.11.1978]. [PMID: 17074950].
[20]
Skapinakis, P.; Caldwell, D.M.; Hollingworth, W.; Bryden, P.; Fineberg, N.A.; Salkovskis, P.; Welton, N.J.; Baxter, H.; Kessler, D.; Churchill, R.; Lewis, G. Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis. Lancet Psychiatry, 2016, 3(8), 730-739. [http://dx.doi.org/10.1016/S2215-0366(16)30069-4]. [PMID: 27318812].
[21]
Cottraux, J.; Bouvard, M.A.; Milliery, M. Combining Pharmacotherapy with cognitive-behavioral interventions for obsessive-compulsive disorder. Cogn. Behav. Ther., 2005, 34(3), 185-192. [http://dx.doi.org/10.1080/16506070510043750]. [PMID: 16201063].
[22]
Pallanti, S.; Quercioli, L. Treatment-refractory obsessive-compulsive disorder: methodological issues, operational definitions and therapeutic lines. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2006, 30(3), 400-412. [http://dx.doi.org/10.1016/j.pnpbp.2005. 11.028]. [PMID: 16503369].
[23]
Kaplan, A.; Hollander, E. A review of pharmacologic treatments for obsessive-compulsive disorder. Psychiatr. Serv., 2003, 54(8), 1111-1118. [http://dx.doi.org/10.1176/appi.ps.54.8.1111]. [PMID: 12883138].
[24]
Simpson, H.B.; Liebowitz, M.R.; Foa, E.B.; Kozak, M.J.; Schmidt, A.B.; Rowan, V.; Petkova, E.; Kjernisted, K.; Huppert, J.D.; Franklin, M.E.; Davies, S.O.; Campeas, R. Post-treatment effects of exposure therapy and clomipramine in obsessive-compulsive disorder. Depress. Anxiety, 2004, 19(4), 225-233. [http://dx.doi.org/10. 1002/da.20003]. [PMID: 15274171].
[25]
Stein, D.J.; Andersen, E.W.; Tonnoir, B.; Fineberg, N. Escitalopram in obsessive-compulsive disorder: a randomized, placebo-controlled, paroxetine-referenced, fixed-dose, 24-week study. Curr. Med. Res. Opin., 2007, 23(4), 701-711. [http://dx.doi.org/10.1185/ 030079907X178838]. [PMID: 17407626].
[26]
Dell’Osso, B.; Nestadt, G.; Allen, A.; Hollander, E. Serotonin-norepinephrine reuptake inhibitors in the treatment of obsessive-compulsive disorder: A critical review. J. Clin. Psychiatry, 2006, 67(4), 600-610. [http://dx.doi.org/10.4088/JCP.v67n0411]. [PMID: 16669725].
[27]
Soomro, G.M.; Altman, D.; Rajagopal, S.; Oakley-Browne, M. Selective serotonin re-uptake inhibitors (SSRIs) versus placebo for obsessive compulsive disorder (OCD). Cochrane Database Syst. Rev., 2008, (1)CD001765 [PMID: 18253995].
[28]
Issari, Y.; Jakubovski, E.; Bartley, C.A.; Pittenger, C.; Bloch, M.H. Early onset of response with selective serotonin reuptake inhibitors in obsessive-compulsive disorder: a meta-analysis. J. Clin. Psychiatry, 2016, 77(5), e605-e611. [http://dx.doi.org/10.4088/JCP. 14r09758]. [PMID: 27249090].
[29]
Fineberg, N.A.; Pampaloni, I.; Pallanti, S.; Ipser, J.; Stein, D.J. Sustained response versus relapse: the pharmacotherapeutic goal for obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2007, 22(6), 313-322. [http://dx.doi.org/10.1097/YIC.0b013e32825 ea312]. [PMID: 17917549].
[30]
Fineberg, N.A.; Tonnoir, B.; Lemming, O.; Stein, D.J. Escitalopram prevents relapse of obsessive-compulsive disorder. Eur. Neuropsychopharmacol., 2007, 17(6-7), 430-439. [http://dx.doi.org/ 10.1016/j.euroneuro.2006.11.005]. [PMID: 17240120].
[31]
Landeros-Weisenberger, A.; Bloch, M.H.; Kelmendi, B.; Wegner, R.; Nudel, J.; Dombrowski, P.; Pittenger, C.; Krystal, J.H.; Goodman, W.K.; Leckman, J.F.; Coric, V. Dimensional predictors of response to SRI pharmacotherapy in obsessive-compulsive disorder. J. Affect. Disord., 2010, 121(1-2), 175-179. [http://dx.doi.org/10. 1016/j.jad.2009.06.010]. [PMID: 19577308].
[32]
Saxena, S.; Brody, A.L.; Ho, M.L.; Zohrabi, N.; Maidment, K.M.; Baxter, L.R., Jr Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression. Am. J. Psychiatry, 2003, 160(3), 522-532. [http://dx.doi. org/10.1176/appi.ajp.160.3.522]. [PMID: 12611834].
[33]
Mataix-Cols, D.; Rauch, S.L.; Manzo, P.A.; Jenike, M.A.; Baer, L. Use of factor-analyzed symptom dimensions to predict outcome with serotonin reuptake inhibitors and placebo in the treatment of obsessive-compulsive disorder. Am. J. Psychiatry, 1999, 156(9), 1409-1416. [PMID: 10484953].
[34]
Erzegovesi, S.; Cavallini, M.C.; Cavedini, P.; Diaferia, G.; Locatelli, M.; Bellodi, L. Clinical predictors of drug response in obsessive-compulsive disorder. J. Clin. Psychopharmacol., 2001, 21(5), 488-492. [http://dx.doi.org/10.1097/00004714-200110000-00006]. [PMID: 11593074].
[35]
Tükel, R.; Bozkurt, O.; Polat, A.; Genç, A.; Atli, H. Clinical predictors of response to pharmacotherapy with selective serotonin reuptake inhibitors in obsessive-compulsive disorder. Psychiatry Clin. Neurosci., 2006, 60(4), 404-409. [PMID: 16884439].
[36]
Hollander, E.; Allen, A.; Steiner, M.; Wheadon, D.E.; Oakes, R.; Burnham, D.B. Acute and long-term treatment and prevention of relapse of obsessive-compulsive disorder with paroxetine. J. Clin. Psychiatry, 2003, 64(9), 1113-1121. [http://dx.doi.org/10.4088/ JCP.v64n0919]. [PMID: 14628989].
[37]
Stein, M.B.; Liebowitz, M.R.; Lydiard, R.B.; Pitts, C.D.; Bushnell, W.; Gergel, I. Paroxetine treatment of generalized social phobia (social anxiety disorder): a randomized controlled trial. JAMA, 1998, 280(8), 708-713. [http://dx.doi.org/10.1001/jama.280.8.708]. [PMID: 9728642].
[38]
Goljevscek, S.; Carvalho, L.A. Current management of obsessive and phobic states. Neuropsychiatr. Dis. Treat., 2011, 7, 599-610. [http://dx.doi.org/10.2147/NDT.S17032]. [PMID: 22003299].
[39]
Zohar, J.; Judge, R. Paroxetine versus clomipramine in the treatment of obsessive-compulsive disorder. Br. J. Psychiatry, 1996, 169(4), 468-474. [http://dx.doi.org/10.1192/bjp.169.4.468]. [PMID: 8894198].
[40]
Li, J.; Xiang, H.; Du, H. Clinical controlled study of paroxetine and clomipramine in treatment of obsessive- compulsive disorder. Chin. J. Psychiatry, 1998, 31(4), 215-217.
[41]
Geller, D.A.; Wagner, K.D.; Emslie, G.; Murphy, T.; Carpenter, D.J.; Wetherhold, E.; Perera, P.; Machin, A.; Gardiner, C. Paroxetine treatment in children and adolescents with obsessive-compulsive disorder: a randomized, multicenter, double-blind, placebo-controlled trial. J. Am. Acad. Child Adolesc. Psychiatry, 2004, 43(11), 1387-1396. [http://dx.doi.org/10.1097/01.chi.0000138356. 29099.f1]. [PMID: 15502598].
[42]
Kamijima, K.; Murasaki, M.; Asai, M.; Higuchi, T.; Nakajima, T.; Taga, C.; Matsunaga, H. Paroxetine in the treatment of obsessive-compulsive disorder: randomized, double-blind, placebo-controlled study in Japanese patients. Psychiatry Clin. Neurosci., 2004, 58(4), 427-433. [http://dx.doi.org/10.1111/j.1440-1819.2004.01278.x]. [PMID: 15298657].
[43]
Ushijima, S.; Kamijima, K.; Asai, M.; Murasaki, M.; Nakajima, T.; Kudo, Y.; Tashiro, N.; Kurihara, M.; Miura, S. Clinical evaluation of sertraline hydrochloride, a selective serotonin reuptake inhibitor in the treatment of obsessive- compulsive disorder: A double blind placebo controlled trial. Jpn. J. Neuropsychoph., 1997, 19(6), 603-623.
[44]
Mallya, G.K.; White, K.; Waternaux, C.; Quay, S. Short- and long-term treatment with obsessive-compulsive disorder with fluvoxamine. Ann. Clin. Psychiatry, 1992, 4, 77-80. [http://dx.doi.org/10. 3109/10401239209150443].
[45]
Nakajima, T.; Kudo, Y.; Yamashita, I.; Asai, M.; Kamijima, K.; Murasaki, M.; Yamaguchi, N.; Saito, M.; Yamawaki, S.; Nishizono, M.; Hishikawa, Y.; Machiyama, Y.; Yamauchi, T.; Moriya, N.; Toru, M.; Hirose, T.; Kojima, T.; Shimizu, M.; Tamura, A.; Endo, S.; Suzuki, J.; Takemasa, K.; Uno, M.; Hasegawa, K.; Kariya, T. Clinical usefulness of Fluvoxamine Maleate (SME3110), a selective serotonin reuptake inhibitor, in the treatment of obsessive compulsive disorder: A double blind, placebo-controlled study investigating the therapeutic dose range and the efficacy of SME3110. J. Clin. Ther. Med., 1996, 12(3), 409-437. [Rinshou Iyaku].
[46]
Nakatani, E.; Nakagawa, A.; Nakao, T.; Yoshizato, C.; Nabeyama, M.; Kudo, A.; Isomura, K.; Kato, N.; Yoshioka, K.; Kawamoto, M. A randomized controlled trial of Japanese patients with obsessive-compulsive disorder--effectiveness of behavior therapy and fluvoxamine. Psychother. Psychosom., 2005, 74(5), 269-276. [http://dx. doi.org/10.1159/000086317]. [PMID: 16088264].
[47]
Hollander, E.; Koran, L.M.; Goodman, W.K.; Greist, J.H.; Ninan, P.T.; Yang, H.; Li, D.; Barbato, L.M. A double-blind, placebo-controlled study of the efficacy and safety of controlled-release fluvoxamine in patients with obsessive-compulsive disorder. J. Clin. Psychiatry, 2003, 64(6), 640-647. [http://dx.doi.org/10.4088/ JCP.v64n0604]. [PMID: 12823077].
[48]
Goodman, W.K.; Kozak, M.J.; Liebowitz, M.; White, K.L. Treatment of obsessive-compulsive disorder with fluvoxamine: a multicentre, double-blind, placebo-controlled trial. Int. Clin. Psychopharmacol., 1996, 11(1), 21-29. [http://dx.doi.org/10.1097/ 00004850-199603000-00003]. [PMID: 8732310].
[49]
Riddle, M.A.; Reeve, E.A.; Yaryura-Tobias, J.A.; Yang, H.M.; Claghorn, J.L.; Gaffney, G.; Greist, J.H.; Holland, D.; McConville, B.J.; Pigott, T.; Walkup, J.T. Fluvoxamine for children and adolescents with obsessive-compulsive disorder: a randomized, controlled, multicenter trial. J. Am. Acad. Child Adolesc. Psychiatry, 2001, 40(2), 222-229. [http://dx.doi.org/10.1097/00004583-200102000-00017]. [PMID: 11211371].
[50]
O’Connor, K.P.; Aardema, F.; Robillard, S.; Guay, S.; Pélissier, M.C.; Todorov, C.; Borgeat, F.; Leblanc, V.; Grenier, S.; Doucet, P. Cognitive behaviour therapy and medication in the treatment of obsessive-compulsive disorder. Acta Psychiatr. Scand., 2006, 113(5), 408-419. [http://dx.doi.org/10.1111/j.1600-0447.2006.00767. x]. [PMID: 16603032].
[51]
Goodman, W.K.; Price, L.H.; Rasmussen, S.A.; Delgado, P.L.; Heninger, G.R.; Charney, D.S. Efficacy of fluvoxamine in obsessive-compulsive disorder. A double-blind comparison with placebo. Arch. Gen. Psychiatry, 1989, 46(1), 36-44. [http://dx.doi. org/10.1001/archpsyc.1989.01810010038006]. [PMID: 2491940].
[52]
Jenike, M.A.; Hyman, S.; Baer, L.; Holland, A.; Minichiello, W.E.; Buttolph, L.; Summergrad, P.; Seymour, R.; Ricciardi, J. A controlled trial of fluvoxamine in obsessive-compulsive disorder: implications for a serotonergic theory. Am. J. Psychiatry, 1990, 147(9), 1209-1215. [http://dx.doi.org/10.1176/ajp.147.9.1209]. [PMID: 2143637].
[53]
Stein, M.B.; Fyer, A.J.; Davidson, J.R.; Pollack, M.H.; Wiita, B. Fluvoxamine treatment of social phobia (social anxiety disorder): a double-blind, placebo-controlled study. Am. J. Psychiatry, 1999, 156(5), 756-760. [PMID: 10327910].
[54]
Ravizza, L.; Barzega, G.; Bellino, S.; Bogetto, F.; Maina, G. Drug treatment of obsessive-compulsive disorder (OCD): long-term trial with clomipramine and selective serotonin reuptake inhibitors (SSRIs). Psychopharmacol. Bull., 1996, 32(1), 167-173. [PMID: 8927668].
[55]
Stein, D.J.; Andersen, E.W.; Overo, K.F. Response of symptom dimensions in obsessive-compulsive disorder to treatment with citalopram or placebo. Rev. Bras. Psiquiatr., 2007, 29(4), 303-307. [http://dx.doi.org/10.1590/S1516-44462007000400003]. [PMID: 18200396].
[56]
Montgomery, S.A.; Kasper, S.; Stein, D.J.; Bang Hedegaard, K.; Lemming, O.M. Citalopram 20 mg, 40 mg and 60 mg are all effective and well tolerated compared with placebo in obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2001, 16(2), 75-86. [http://dx.doi.org/10.1097/00004850-200103000-00002]. [PMID: 11236072].
[57]
Atmaca, M.; Kuloglu, M.; Tezcan, E.; Unal, A. Efficacy of citalopram and moclobemide in patients with social phobia: some preliminary findings. Hum. Psychopharmacol., 2002, 17(8), 401-405. [http://dx.doi.org/10.1002/hup.436]. [PMID: 12457375].
[58]
Marazziti, D.; Golia, F.; Consoli, G.; Presta, S.; Pfanner, C.; Carlini, M.; Mungai, F.; Catena Dell’osso, M. Effectiveness of long-term augmentation with citalopram to clomipramine in treatment-resistant OCD patients. CNS Spectr., 2008, 13(11), 971-976. [http:// dx.doi.org/10.1017/S1092852900014024]. [PMID: 19037176].
[59]
Sánchez, C.; Bergqvist, P.B.; Brennum, L.T.; Gupta, S.; Hogg, S.; Larsen, A.; Wiborg, O. Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl.), 2003, 167(4), 353-362. [http://dx.doi.org/10.1007/s00213-002-1364-z]. [PMID: 12719960].
[60]
von Moltke, L.L.; Greenblatt, D.J.; Giancarlo, G.M.; Granda, B.W.; Harmatz, J.S.; Shader, R.I. Escitalopram (S-citalopram) and its metabolites in vitro: cytochromes mediating biotransformation, inhibitory effects, and comparison to R-citalopram. Drug Metab. Dispos., 2001, 29(8), 1102-1109. [PMID: 11454728].
[61]
Burke, W.J.; Kratochvil, C.J. Stereoisomers in Psychiatry: The Case of Escitalopram. Prim. Care Companion J. Clin. Psychiatry, 2002, 4(1), 20-24. [http://dx.doi.org/10.4088/PCC.v04n0107]. [PMID: 15014731].
[62]
Lader, M.; Stender, K.; Bürger, V.; Nil, R. Efficacy and tolerability of escitalopram in 12- and 24-week treatment of social anxiety disorder: randomised, double-blind, placebo-controlled, fixed-dose study. Depress. Anxiety, 2004, 19(4), 241-248. [http://dx.doi. org/10.1002/da.20014]. [PMID: 15274173].
[63]
Tollefson, G.D.; Rampey, A.H., Jr; Potvin, J.H.; Jenike, M.A.; Rush, A.J. kominguez, R.A.; Koran, L.M.; Shear, M.K.; Goodman, W.; Genduso, L.A. A multicenter investigation of fixed-dose fluoxetine in the treatment of obsessive-compulsive disorder. Arch. Gen. Psychiatry, 1994, 51(7), 559-567. [http://dx.doi.org/10.1001/ archpsyc.1994.03950070051010]. [PMID: 8031229].
[64]
Romano, S.; Goodman, W.; Tamura, R.; Gonzales, J. Long-term treatment of obsessive-compulsive disorder after an acute response: a comparison of fluoxetine versus placebo. J. Clin. Psychopharmacol., 2001, 21(1), 46-52. [http://dx.doi.org/10.1097/00004714-200102000-00009]. [PMID: 11199947].
[65]
Phillips, K.A.; Rasmussen, S.A. Change in psychosocial functioning and quality of life of patients with body dysmorphic disorder treated with fluoxetine: a placebo-controlled study. Psychosomatics, 2004, 45(5), 438-444. [http://dx.doi.org/10.1176/appi.psy.45.5.438]. [PMID: 15345790].
[66]
Davidson, J.R.; Foa, E.B.; Huppert, J.D.; Keefe, F.J.; Franklin, M.E.; Compton, J.S.; Zhao, N.; Connor, K.M.; Lynch, T.R.; Gadde, K.M. Fluoxetine, comprehensive cognitive behavioral therapy, and placebo in generalized social phobia. Arch. Gen. Psychiatry, 2004, 61(10), 1005-1013. [http://dx.doi.org/10.1001/archpsyc.61.10.1005]. [PMID: 15466674].
[67]
Riddle, M.A.; Scahill, L.; King, R.A.; Hardin, M.T.; Anderson, G.M.; Ort, S.I.; Smith, J.C.; Leckman, J.F.; Cohen, D.J. Double-blind, crossover trial of fluoxetine and placebo in children and adolescents with obsessive-compulsive disorder. J. Am. Acad. Child Adolesc. Psychiatry, 1992, 31(6), 1062-1069. [http://dx.doi.org/10. 1097/00004583-199211000-00011]. [PMID: 1429406].
[68]
Montgomery, S.A.; McIntyre, A.; Osterheider, M.; Sarteschi, P.; Zitterl, W.; Zohar, J.; Birkett, M.; Wood, A.J. A double-blind, placebo-controlled study of fluoxetine in patients with DSM-III-R obsessive-compulsive disorder. Eur. Neuropsychopharmacol., 1993, 3(2), 143-152. [http://dx.doi.org/10.1016/0924-977X(93)90266-O]. [PMID: 8364350].
[69]
Geller, D.A.; Hoog, S.L.; Heiligenstein, J.H.; Ricardi, R.K.; Tamura, R.; Kluszynski, S.; Jacobson, J.G. Fluoxetine treatment for obsessive-compulsive disorder in children and adolescents: a placebo-controlled clinical trial. J. Am. Acad. Child Adolesc. Psychiatry, 2001, 40(7), 773-779. [http://dx.doi.org/10.1097/00004583-200107000-00011]. [PMID: 11437015].
[70]
Tollefson, G.D.; Birkett, M.; Koran, L.; Genduso, L. Continuation treatment of OCD: double-blind and open-label experience with fluoxetine. J. Clin. Psychiatry, 1994, 55(Suppl.), 69-76. [PMID: 7961535].
[71]
Jenike, M.A.; Baer, L.; Minichiello, W.E.; Rauch, S.L.; Buttolph, M.L. Placebo-controlled trial of fluoxetine and phenelzine for obsessive-compulsive disorder. Am. J. Psychiatry, 1997, 154(9), 1261-1264. [http://dx.doi.org/10.1176/ajp.154.9.1261]. [PMID: 9286186].
[72]
Greist, J.; Chouinard, G.; DuBoff, E.; Halaris, A.; Kim, S.W.; Koran, L.; Liebowitz, M.; Lydiard, R.B.; Rasmussen, S.; White, K.; Sikes, C. Double-blind parallel comparison of three dosages of sertraline and placebo in outpatients with obsessive-compulsive disorder. Arch. Gen. Psychiatry, 1995, 52(4), 289-295. [http://dx.doi. org/10.1001/archpsyc.1995.03950160039008]. [PMID: 7702445].
[73]
Liebowitz, M.R.; DeMartinis, N.A.; Weihs, K.; Londborg, P.D.; Smith, W.T.; Chung, H.; Fayyad, R.; Clary, C.M. Efficacy of sertraline in severe generalized social anxiety disorder: results of a double-blind, placebo-controlled study. J. Clin. Psychiatry, 2003, 64(7), 785-792. [http://dx.doi.org/10.4088/JCP.v64n0708]. [PMID: 12934979].
[74]
Van Ameringen, M.A.; Lane, R.M.; Walker, J.R.; Bowen, R.C.; Chokka, P.R.; Goldner, E.M.; Johnston, D.G.; Lavallee, Y.J.; Nandy, S.; Pecknold, J.C.; Hadrava, V.; Swinson, R.P. Sertraline treatment of generalized social phobia: a 20-week, double-blind, placebo-controlled study. Am. J. Psychiatry, 2001, 158(2), 275-281. [http://dx.doi.org/10.1176/appi.ajp.158.2.275]. [PMID: 11156811].
[75]
Kronig, M.H.; Apter, J.; Asnis, G.; Bystritsky, A.; Curtis, G.; Ferguson, J.; Landbloom, R.; Munjack, D.; Riesenberg, R.; Robinson, D.; Roy-Byrne, P.; Phillips, K.; Du Pont, I.J. Placebo-controlled, multicenter study of sertraline treatment for obsessive-compulsive disorder. J. Clin. Psychopharmacol., 1999, 19(2), 172-176. [http://dx.doi.org/10.1097/00004714-199904000-00013]. [PMID: 10211919].
[76]
Koran, L.M.; Hackett, E.; Rubin, A.; Wolkow, R.; Robinson, D. Efficacy of sertraline in the long-term treatment of obsessive-compulsive disorder. Am. J. Psychiatry, 2002, 159(1), 88-95. [http://dx.doi.org/10.1176/appi.ajp.159.1.88]. [PMID: 11772695].
[77]
Chouinard, G.; Goodman, W.; Greist, J.; Jenike, M.; Rasmussen, S.; White, K.; Hackett, E.; Gaffney, M.; Bick, P.A. Results of a double-blind placebo controlled trial of a new serotonin uptake inhibitor, sertraline, in the treatment of obsessive-compulsive disorder. Psychopharmacol. Bull., 1990, 26(3), 279-284. [PMID: 2274626].
[78]
Ninan, P.T.; Koran, L.M.; Kiev, A.; Davidson, J.R.; Rasmussen, S.A.; Zajecka, J.M.; Robinson, D.G.; Crits-Christoph, P.; Mandel, F.S.; Austin, C. High-dose sertraline strategy for nonresponders to acute treatment for obsessive-compulsive disorder: a multicenter double-blind trial. J. Clin. Psychiatry, 2006, 67(1), 15-22. [http:// dx.doi.org/10.4088/JCP.v67n0103]. [PMID: 16426083].
[79]
Abramowitz, J.S. Effectiveness of psychological and pharmacological treatments for obsessive-compulsive disorder: a quantitative review. J. Consult. Clin. Psychol., 1997, 65(1), 44-52. [http://dx. doi.org/10.1037/0022-006X.65.1.44]. [PMID: 9103733].
[80]
Foa, E.B.; Liebowitz, M.R.; Kozak, M.J.; Davies, S.; Campeas, R.; Franklin, M.E.; Huppert, J.D.; Kjernisted, K.; Rowan, V.; Schmidt, A.B.; Simpson, H.B.; Tu, X. Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder. Am. J. Psychiatry, 2005, 162(1), 151-161. [http://dx.doi.org/10.1176/appi. ajp.162.1.151]. [PMID: 15625214].
[81]
Fallon, B.A.; Mathew, S.J. Biological therapies for obsessive-compulsive disorder. J. Psychiatr. Pract., 2000, 6(3), 113-128. [http://dx.doi.org/10.1097/00131746-200005000-00002]. [PMID: 15990479].
[82]
Jenike, M.A.; Baer, L.; Summergrad, P.; Weilburg, J.B.; Holland, A.; Seymour, R. Obsessive-compulsive disorder: a double-blind, placebo-controlled trial of clomipramine in 27 patients. Am. J. Psychiatry, 1989, 146(10), 1328-1330. [http://dx.doi.org/10.1176/ ajp.146.10.1328]. [PMID: 2675643].
[83]
Greist, J.H.; Jefferson, J.W.; Rosenfeld, R.; Gutzmann, L.D.; March, J.S.; Barklage, N.E. Clomipramine and obsessive compulsive disorder: a placebo-controlled double-blind study of 32 patients. J. Clin. Psychiatry, 1990, 51(7), 292-297. [PMID: 2195006].
[84]
Clomipramine in the treatment of patients with obsessive-compulsive disorder. Arch. Gen. Psychiatry, 1991, 48(8), 730-738. [http://dx.doi.org/10.1001/archpsyc.1991.01810320054008]. [PMID: 1883256].
[85]
Hoehn-Saric, R.; McLeod, D.R.; Zimmerli, W.D.; Hipsley, P.A. Symptoms and physiologic manifestations in obsessive compulsive patients before and after treatment with clomipramine. J. Clin. Psychiatry, 1993, 54(7), 272-276. [PMID: 8335655].
[86]
Mavissakalian, M.R.; Jones, B.; Olson, S.; Perel, J.M. Clomipramine in obsessive-compulsive disorder: clinical response and plasma levels. J. Clin. Psychopharmacol., 1990, 10(4), 261-268. [http://dx.doi.org/10.1097/00004714-199008000-00005]. [PMID: 2286699].
[87]
Albert, U.; Aguglia, E.; Maina, G.; Bogetto, F. Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: a preliminary single-blind, 12-week, controlled study. J. Clin. Psychiatry, 2002, 63(11), 1004-1009. [http://dx.doi.org/10.4088/JCP. v63n1108]. [PMID: 12444814].
[88]
Rauch, S.L.; O’Sullivan, R.L.; Jenike, M.A. Open treatment of obsessive-compulsive disorder with venlafaxine: a series of ten cases. J. Clin. Psychopharmacol., 1996, 16(1), 81-84. [http://dx. doi.org/10.1097/00004714-199602000-00017]. [PMID: 8834427].
[89]
Sevincok, L.; Uygur, B. Venlafaxine open-label treatment of patients with obsessive-compulsive disorder. Aust. N. Z. J. Psychiatry, 2002, 36(6), 817. [http://dx.doi.org/10.1046/j.1440-1614.2002. t01-5-01101c.x]. [PMID: 12406128].
[90]
Hollander, E.; Friedberg, J.; Wasserman, S.; Allen, A.; Birnbaum, M.; Koran, L.M. Venlafaxine in treatment-resistant obsessive-compulsive disorder. J. Clin. Psychiatry, 2003, 64(5), 546-550. [http://dx.doi.org/10.4088/JCP.v64n0508]. [PMID: 12755657].
[91]
Liebowitz, M.R.; Gelenberg, A.J.; Munjack, D. Venlafaxine extended release vs placebo and paroxetine in social anxiety disorder. Arch. Gen. Psychiatry, 2005, 62(2), 190-198. [http://dx.doi.org/10. 1001/archpsyc.62.2.190]. [PMID: 15699296].
[92]
Stein, M.B.; Pollack, M.H.; Bystritsky, A.; Kelsey, J.E.; Mangano, R.M. Efficacy of low and higher dose extended-release venlafaxine in generalized social anxiety disorder: a 6-month randomized controlled trial. Psychopharmacology (Berl.), 2005, 177(3), 280-288. [http://dx.doi.org/10.1007/s00213-004-1957-9]. [PMID: 15258718].
[93]
Denys, D.; van der Wee, N.; van Megen, H.J.; Westenberg, H.G. A double blind comparison of venlafaxine and paroxetine in obsessive-compulsive disorder. J. Clin. Psychopharmacol., 2003, 23(6), 568-575. [http://dx.doi.org/10.1097/01.jcp.0000095342.32154.54]. [PMID: 14624187].
[94]
Luís Blay, S.; Black, D.W. A case of obsessive-compulsive disorder responding to duloxetine. Prim. Care Companion J. Clin. Psychiatry, 2007, 9(3), 234-235. [http://dx.doi.org/10.4088/PCC. v09n0311c]. [PMID: 17632660].
[95]
Dell’osso, B.; Mundo, E.; Marazziti, D.; Altamura, A.C. Switching from serotonin reuptake inhibitors to duloxetine in patients with resistant obsessive compulsive disorder: a case series. J. Psychopharmacol. (Oxford), 2008, 22(2), 210-213. [http://dx.doi.org/10. 1177/0269881107079865]. [PMID: 18208931].
[96]
Yeh, Y.W.; Chen, C.H.; Kuo, S.C.; Wang, S.C.; Chen, C.K.; Feng, H.M. High-dose duloxetine for treatment-resistant obsessive-compulsive disorder: a case report with sustained full remission. Clin. Neuropharmacol., 2009, 32(3), 174-176. [http://dx.doi.org/10. 1097/WNF.0b013e31817f8cef]. [PMID: 19483491].
[97]
Yoshida, K.; Higuchi, H.; Ozaki, N. Successful treatment of severe antidepressant-induced nausea with a combination of milnacipran and olanzapine. Pharmacopsychiatry, 2007, 40(2), 84-85. [http:// dx.doi.org/10.1055/s-2007-970061]. [PMID: 17447181].
[98]
De Berardis, D.; Conti, C.M.; Marini, S.; Ferri, F.; Iasevoli, F.; Valchera, A.; Fornaro, M.; Cavuto, M.; Srinivasan, V.; Perna, G.; Carano, A.; Piersanti, M.; Martinotti, G.; Di Giannantonio, M. Is there a role for agomelatine in the treatment of anxiety disorders?A review of published data. Int. J. Immunopathol. Pharmacol., 2013, 26(2), 299-304. [http://dx.doi.org/10.1177/039463201302600203]. [PMID: 23755745].
[99]
Fornaro, M. Switching from serotonin reuptake inhibitors to agomelatine in patients with refractory obsessive-compulsive disorder: a 3 month follow-up case series. Ann. Gen. Psychiatry, 2011, 10(1), 5. [http://dx.doi.org/10.1186/1744-859X-10-5]. [PMID: 21356085].
[100]
Tzavellas, E.; Karaiskos, D.; Ilias, I.; Liappas, I.; Paparrigopoulos, T. Agomelatine augmentation in obsessive compulsive disorder: a preliminary report. Psychiatriki, 2014, 25(3), 179-184. [PMID: 25367661].
[101]
Roca, A.; Garcia-Esteve, L.; Imaz, M.L.; Torres, A.; Hernández, S.; Botet, F.; Gelabert, E.; Subirà, S.; Plaza, A.; Valdés, M.; Martin-Santos, R. Obstetrical and neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitors: the relevance of dose. J. Affect. Disord., 2011, 135(1-3), 208-215. [http://dx.doi. org/10.1016/j.jad.2011.07.022]. [PMID: 21890210].
[102]
Koran, L.M.; Gamel, N.N.; Choung, H.W.; Smith, E.H.; Aboujaoude, E.N. Mirtazapine for obsessive-compulsive disorder: an open trial followed by double-blind discontinuation. J. Clin. Psychiatry, 2005, 66(4), 515-520. [http://dx.doi.org/10.4088/JCP. v66n0415]. [PMID: 15816795].
[103]
Pigott, T.A.; L’Heureux, F.; Rubenstein, C.S.; Bernstein, S.E.; Hill, J.L.; Murphy, D.L. A double-blind, placebo controlled study of trazodone in patients with obsessive-compulsive disorder. J. Clin. Psychopharmacol., 1992, 12(3), 156-162.
[104]
McDougle, C.J.; Epperson, C.N.; Pelton, G.H.; Wasylink, S.; Price, L.H. A double-blind, placebo-controlled study of risperidone addition in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder. Arch. Gen. Psychiatry, 2000, 57(8), 794-801. [http://dx.doi.org/10.1001/archpsyc.57.8.794]. [PMID: 10920469].
[105]
Ravindran, L.N.; Jung, S.M.; Ravindran, A.V. Intravenous anti-obsessive agents: a review. J. Psychopharmacol. (Oxford), 2010, 24(3), 287-296. [http://dx.doi.org/10.1177/0269881108096508]. [PMID: 18801828].
[106]
Pallanti, S.; Quercioli, L.; Koran, L.M. Citalopram intravenous infusion in resistant obsessive-compulsive disorder: an open trial. J. Clin. Psychiatry, 2002, 63(9), 796-801. [http://dx.doi.org/10.4088/ JCP.v63n0908]. [PMID: 12363120].
[107]
Fallon, B.A.; Liebowitz, M.R.; Campeas, R.; Schneier, F.R.; Marshall, R.; Davies, S.; Goetz, D.; Klein, D.F. Intravenous clomipramine for obsessive-compulsive disorder refractory to oral clomipramine: a placebo-controlled study. Arch. Gen. Psychiatry, 1998, 55(10), 918-924. [http://dx.doi.org/10.1001/archpsyc.55.10. 918]. [PMID: 9783563].
[108]
Koran, L.M.; Sallee, F.R.; Pallanti, S. Rapid benefit of intravenous pulse loading of clomipramine in obsessive-compulsive disorder. Am. J. Psychiatry, 1997, 154(3), 396-401. [http://dx.doi.org/10. 1176/ajp.154.3.396]. [PMID: 9054789].
[109]
Rabinowitz, I.; Baruch, Y.; Barak, Y. High-dose escitalopram for the treatment of obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2008, 23(1), 49-53. [http://dx.doi.org/10.1097/YIC. 0b013e3282f0f0c5]. [PMID: 18090508].
[110]
Dougherty, D.D.; Jameson, M.; Deckersbach, T.; Loh, R.; Thompson-Hollands, J.; Jenike, M.; Keuthen, N.J. Open-label study of high (30 mg) and moderate (20 mg) dose escitalopram for the treatment of obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2009, 24(6), 306-311. [http://dx.doi.org/10.1097/YIC. 0b013e32833119d8]. [PMID: 19730388].
[111]
Hollander, E.; Bienstock, C.A.; Koran, L.M.; Pallanti, S.; Marazziti, D.; Rasmussen, S.A.; Ravizza, L.; Benkelfat, C.; Saxena, S.; Greenberg, B.D.; Sasson, Y.; Zohar, J. Refractory obsessive-compulsive disorder: state-of-the-art treatment. J. Clin. Psychiatry, 2002, 63(Suppl. 6), 20-29. [PMID: 12027116].
[112]
Denys, D.; Zohar, J.; Westenberg, H.G. The role of dopamine in obsessive-compulsive disorder: preclinical and clinical evidence. J. Clin. Psychiatry, 2004, 65(Suppl. 14), 11-17. [PMID: 15554783].
[113]
Schirmbeck, F.; Zink, M. Comorbid obsessive-compulsive symptoms in schizophrenia: contributions of pharmacological and genetic factors. Front. Pharmacol., 2013, 4, 99. [http://dx.doi.org/10. 3389/fphar.2013.00099]. [PMID: 23950745].
[114]
Gordon, A. Transition of obsessions into delusions. Evaluation of obsessional phenomena from the prognostic standpoint. Am. J. Psychiatry, 1950, 107(6), 455-458. [http://dx.doi.org/10.1176/ ajp.107.6.455]. [PMID: 14838150].
[115]
Klemperer, F. Compulsions developing into command hallucinations. Psychopathology, 1996, 29(4), 249-251. [http://dx.doi.org/ 10.1159/000285001]. [PMID: 8865357].
[116]
Devi, S.; Rao, N.P.; Badamath, S.; Chandrashekhar, C.R.; Janardhan Reddy, Y.C. Prevalence and clinical correlates of obsessive-compulsive disorder in schizophrenia. Compr. Psychiatry, 2015, 56, 141-148. [http://dx.doi.org/10.1016/j.comppsych.2014.09.015]. [PMID: 25308405].
[117]
Kapur, S.; Remington, G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am. J. Psychiatry, 1996, 153(4), 466-476. [http://dx.doi.org/10.1176/ajp.153.4.466]. [PMID: 8599393].
[118]
Pollitt, J.D. Natural history studies in mental illness. A discussion based on a pilot study of obsessional states. J. Ment. Sci., 1960, 106, 93-113. [http://dx.doi.org/10.1192/bjp.106.442.93]. [PMID: 14433876].
[119]
Ingram, I.M. Obsessional illness in mental hospital patients. J. Ment. Sci., 1961, 107, 382-402. [http://dx.doi.org/10.1192/bjp.107. 448.382]. [PMID: 13717718].
[120]
Lo, W.H. A follow-up study of obsessional neurotics in Hong Kong Chinese. Br. J. Psychiatry, 1967, 113(501), 823-832. [http://dx.doi.org/10.1192/bjp.113.501.823]. [PMID: 6048368].
[121]
Welner, A.; Reich, T.; Robins, E.; Fishman, R.; Van Doren, T. Obsessive-compulsive neurosis: record, follow-up, and family studies. I. Inpatient record study. Compr. Psychiatry, 1976, 17(4), 527-539. [http://dx.doi.org/10.1016/0010-440X(76)90035-3]. [PMID: 963994].
[122]
Jenike, M.A.; Baer, L.; Minichiello, W.E.; Schwartz, C.E.; Carey, R.J., Jr Coexistent obsessive-compulsive disorder and schizotypal personality disorder: a poor prognostic indicator. Arch. Gen. Psychiatry, 1986, 43(3), 296. [http://dx.doi.org/10.1001/archpsyc. 1986.01800030114016]. [PMID: 3954553].
[123]
Joffe, R.T.; Swinson, R.P.; Regan, J.J. Personality features of obsessive-compulsive disorder. Am. J. Psychiatry, 1988, 145(9), 1127-1129. [http://dx.doi.org/10.1176/ajp.145.9.1127]. [PMID: 3414855].
[124]
Baer, L.; Jenike, M.A.; Ricciardi, J.N., II; Holland, A.D.; Seymour, R.J.; Minichiello, W.E.; Buttolph, M.L. Standardized assessment of personality disorders in obsessive-compulsive disorder. Arch. Gen. Psychiatry, 1990, 47(9), 826-830. [http://dx.doi.org/10.1001/ archpsyc.1990.01810210034005]. [PMID: 2393341].
[125]
Ganesan, V.; Kumar, T.C.; Khanna, S. Obsessive--compulsive disorder and psychosis. Can. J. Psychiatry, 2001, 46(8), 750-754. [http://dx.doi.org/10.1177/070674370104600809]. [PMID: 11692979].
[126]
American Psychiatric Association. Practice Guidelines for the Treatment of Patients with Obsessive-Compulsive Disorder; American Psychiatric Association: Arlington, VA, 2007.
[127]
Bandelow, B.; Zohar, J.; Hollander, E.; Kasper, S.; Möller, H.J.; Zohar, J.; Hollander, E.; Kasper, S.; Möller, H.J.; Bandelow, B.; Allgulander, C.; Ayuso-Gutierrez, J.; Baldwin, D.S.; Buenvicius, R.; Cassano, G.; Fineberg, N.; Gabriels, L.; Hindmarch, I.; Kaiya, H.; Klein, D.F.; Lader, M.; Lecrubier, Y.; Lépine, J.P.; Liebowitz, M.R.; Lopez-Ibor, J.J.; Marazziti, D.; Miguel, E.C.; Oh, K.S.; Preter, M.; Rupprecht, R.; Sato, M.; Starcevic, V.; Stein, D.J.; van Ameringen, M.; Vega, J. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of anxiety, obsessive-compulsive and post-traumatic stress disorders - first revision. World J. Biol. Psychiatry, 2008, 9(4), 248-312. [http://dx.doi.org/10.1080/15622970802465807]. [PMID: 18949648].
[128]
Van Ameringen, M.; Simpson, W.; Patterson, B.; Dell’Osso, B.; Fineberg, N.; Hollander, E.; Hranov, L.; Hranov, G.; Lochner, C.; Karamustafalioglu, O.; Marazziti, D.; Menchon, J.M.; Nicolini, H.; Pallanti, S.; Stein, D.J.; Zohar, J. Pharmacological treatment strategies in obsessive compulsive disorder: A cross-sectional view in nine international OCD centers. J. Psychopharmacol. (Oxford), 2014, 28(6), 596-602. [http://dx.doi.org/10.1177/0269881113517955]. [PMID: 24429223].
[129]
Phillips, K.A. Placebo-controlled study of pimozide augmentation of fluoxetine in body dysmorphic disorder. Am. J. Psychiatry, 2005, 162(2), 377-379. [http://dx.doi.org/10.1176/appi.ajp.162.2.377]. [PMID: 15677604].
[130]
Albert, U.; Carmassi, C.; Cosci, F.; De Cori, D.; Di Nicola, M.; Ferrari, S.; Poloni, N.; Tarricone, I.; Fiorillo, A. Role and clinical implications of atypical antipsychotics in anxiety disorders, obsessive-compulsive disorder, trauma-related, and somatic symptom disorders: a systematized review. Int. Clin. Psychopharmacol., 2016, 31(5), 249-258. [http://dx.doi.org/10.1097/YIC. 0000000000000127]. [PMID: 26974213].
[131]
Albert, U.; Marazziti, D.; Di Salvo, G.; Solia, F.; Rosso, G.; Maina, G. A systematic review of evidence-based treatment strategies for obsessive-compulsive disorder resistant to first-line pharmacotherapy. Curr. Med. Chem., 2018, 25(41), 5647-5661. [http://dx. doi.org/10.2174/0929867325666171222163645]. [PMID: 29278206].
[132]
Komossa, K.; Depping, A.M.; Meyer, M.; Kissling, W.; Leucht, S. Second-generation antipsychotics for obsessive compulsive disorder. Cochrane Database Syst. Rev., 2010, 12(12)CD008141 [PMID: 21154394].
[133]
Dold, M.; Aigner, M.; Lanzenberger, R.; Kasper, S. Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a meta-analysis of double-blind, randomized, placebo-controlled trials. Int. J. Neuropsychopharmacol., 2013, 16(3), 557-574. [http://dx.doi.org/10.1017/S146114571 2000740]. [PMID: 22932229].
[134]
Li, X.; May, R.S.; Tolbert, L.C.; Jackson, W.T.; Flournoy, J.M.; Baxter, L.R. Risperidone and haloperidol augmentation of serotonin reuptake inhibitors in refractory obsessive-compulsive disorder: a crossover study. J. Clin. Psychiatry, 2005, 66(6), 736-743. [http://dx.doi.org/10.4088/JCP.v66n0610]. [PMID: 15960567].
[135]
Hollander, E.; Baldini, R.N.; Sood, E.; Pallanti, S. Risperidone augmentation in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. Int. J. Neuropsychopharmacol., 2003, 6(4), 397-401. [http://dx.doi.org/10.1017/S14611 45703003730]. [PMID: 14604454].
[136]
Buchsbaum, M.S.; Hollander, E.; Pallanti, S.; Baldini, R.N.; Platholi, J.; Newmark, R.; Bloom, R.; Sood, E. Positron emission tomography imaging of risperidone augmentation in serotonin reuptake inhibitor-refractory patients. Neuropsychobiology, 2006, 53(3), 157-168. [http://dx.doi.org/10.1159/000093342]. [PMID: 16707915].
[137]
Erzegovesi, S.; Guglielmo, E.; Siliprandi, F.; Bellodi, L. Low-dose risperidone augmentation of fluvoxamine treatment in obsessive-compulsive disorder: a double-blind, placebo-controlled study. Eur. Neuropsychopharmacol., 2005, 15(1), 69-74. [http://dx.doi.org/10. 1016/j.euroneuro.2004.04.004]. [PMID: 15572275].
[138]
Simpson, H.B.; Foa, E.B.; Liebowitz, M.R.; Huppert, J.D.; Cahill, S.; Maher, M.J.; McLean, C.P.; Bender, J., Jr; Marcus, S.M.; Williams, M.T.; Weaver, J.; Vermes, D.; Van Meter, P.E.; Rodriguez, C.I.; Powers, M.; Pinto, A.; Imms, P.; Hahn, C.G.; Campeas, R. Cognitive-behavioral therapy vs. risperidone for augmenting serotonin reuptake inhibitors in obsessive-compulsive disorder: a randomized clinical trial. JAMA Psychiatry, 2013, 70(11), 1190-1199. [http://dx.doi.org/10.1001/jamapsychiatry.2013.1932]. [PMID: 24026523].
[139]
Savas, H.A.; Yumru, M.; Ozen, M.E. Quetiapine and ziprasidone as adjuncts in treatment-resistant obsessive-compulsive disorder: a retrospective comparative study. Clin. Drug Investig., 2008, 28(7), 439-442. [http://dx.doi.org/10.2165/00044011-200828070-00005]. [PMID: 18544004].
[140]
Maina, G.; Pessina, E.; Albert, U.; Bogetto, F. 8-week, single-blind, randomized trial comparing risperidone versus olanzapine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder. Eur. Neuropsychopharmacol., 2008, 18(5), 364-372. [http://dx.doi.org/10.1016/j.euroneuro.2008. 01.001]. [PMID: 18280710].
[141]
Selvi, Y.; Atli, A.; Aydin, A.; Besiroglu, L.; Ozdemir, P.; Ozdemir, O. The comparison of aripiprazole and risperidone augmentation in selective serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a single-blind, randomised study. Hum. Psychopharmacol., 2011, 26(1), 51-57. [http://dx.doi.org/10.1002/hup. 1169]. [PMID: 21308781].
[142]
Vulink, N.C.; Denys, D.; Fluitman, S.B.; Meinardi, J.C.; Westenberg, H.G. Quetiapine augments the effect of citalopram in non-refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled study of 76 patients. J. Clin. Psychiatry, 2009, 70(7), 1001-1008. [http://dx.doi.org/10.4088/JCP.08m04269]. [PMID: 19497245].
[143]
Fineberg, N.A.; Sivakumaran, T.; Roberts, A.; Gale, T. Adding quetiapine to SRI in treatment-resistant obsessive-compulsive disorder: a randomized controlled treatment study. Int. Clin. Psychopharmacol., 2005, 20(4), 223-226. [http://dx.doi.org/10.1097/ 00004850-200507000-00005]. [PMID: 15933483].
[144]
Atmaca, M.; Kuloglu, M.; Tezcan, E.; Gecici, O. Quetiapine augmentation in patients with treatment resistant obsessive-compulsive disorder: a single-blind, placebo-controlled study. Int. Clin. Psychopharmacol., 2002, 17(3), 115-119. [http://dx.doi.org/10.1097/ 00004850-200205000-00004]. [PMID: 11981352].
[145]
Denys, D.; de Geus, F.; van Megen, H.J.; Westenberg, H.G. A double-blind, randomized, placebo-controlled trial of quetiapine addition in patients with obsessive-compulsive disorder refractory to serotonin reuptake inhibitors. J. Clin. Psychiatry, 2004, 65(8), 1040-1048. [http://dx.doi.org/10.4088/JCP.v65n0803]. [PMID: 15323587].
[146]
Carey, P.D.; Vythilingum, B.; Seedat, S.; Muller, J.E.; van Ameringen, M.; Stein, D.J. Quetiapine augmentation of SRIs in treatment refractory obsessive-compulsive disorder: a double-blind, randomised, placebo-controlled study.[ISRCTN83050762]. BMC Psychiatry, 2005, 5(5), 5. [http://dx.doi.org/10.1186/1471-244X-5-5]. [PMID: 15667657].
[147]
Kordon, A.; Wahl, K.; Koch, N.; Zurowski, B.; Anlauf, M.; Vielhaber, K.; Kahl, K.G.; Broocks, A.; Voderholzer, U.; Hohagen, F. Quetiapine addition to serotonin reuptake inhibitors in patients with severe obsessive-compulsive disorder: a double-blind, randomized, placebo-controlled study. J. Clin. Psychopharmacol., 2008, 28(5), 550-554. [http://dx.doi.org/10.1097/JCP.0b013e318185e735]. [PMID: 18794652].
[148]
Dold, M.; Aigner, M.; Lanzenberger, R.; Kasper, S. Antipsychotic augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: an update meta-analysis of double-blind, randomized, placebo-controlled trials. Int. J. Neuropsychopharmacol., 2015, 18(9) [http://dx.doi.org/10.1093/ijnp/pyv047].
[149]
Veale, D.; Miles, S.; Smallcombe, N.; Ghezai, H.; Goldacre, B.; Hodsoll, J. Atypical antipsychotic augmentation in SSRI treatment refractory obsessive-compulsive disorder: a systematic review and meta-analysis. BMC Psychiatry, 2014, 14, 317. [http://dx.doi. org/10.1186/s12888-014-0317-5]. [PMID: 25432131].
[150]
McDougle, C.J.; Goodman, W.K.; Leckman, J.F.; Lee, N.C.; Heninger, G.R.; Price, L.H. Haloperidol addition in fluvoxamine-refractory obsessive-compulsive disorder. A double-blind, placebo-controlled study in patients with and without tics. Arch. Gen. Psychiatry, 1994, 51(4), 302-308. [http://dx.doi.org/10.1001/archpsyc. 1994.03950040046006]. [PMID: 8161290].
[151]
Mohr, N.; Vythilingum, B.; Emsley, R.A.; Stein, D.J. Quetiapine augmentation of serotonin reuptake inhibitors in obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2002, 17(1), 37-40. [http://dx.doi.org/10.1097/00004850-200201000-00006]. [PMID: 11800505].
[152]
Bogetto, F.; Bellino, S.; Vaschetto, P.; Ziero, S. Olanzapine augmentation of fluvoxamine-refractory obsessive-compulsive disorder (OCD): a 12-week open trial. Psychiatry Res., 2000, 96(2), 91-98. [http://dx.doi.org/10.1016/S0165-1781(00)00203-1]. [PMID: 11063782].
[153]
Metin, O.; Yazici, K.; Tot, S.; Yazici, A.E. Amisulpiride augmentation in treatment resistant obsessive-compulsive disorder: an open trial. Hum. Psychopharmacol., 2003, 18(6), 463-467. [http://dx. doi.org/10.1002/hup.512]. [PMID: 12923825].
[154]
Uguz, F. Successful treatment of comorbid obsessive-compulsive disorder with aripiprazole in three patients with bipolar disorder. Gen. Hosp. Psychiatry, 2010, 32(5), 556-558. [http://dx.doi.org/10. 1016/j.genhosppsych.2010.07.004]. [PMID: 20851277].
[155]
Glick, I.D.; Poyurovsky, M.; Ivanova, O.; Koran, L.M. Aripiprazole in schizophrenia patients with comorbid obsessive-compulsive symptoms: an open-label study of 15 patients. J. Clin. Psychiatry, 2008, 69(12), 1856-1859. [http://dx.doi.org/10.4088/JCP.v69n1202]. [PMID: 19026264].
[156]
Murphy, T.K.; Mutch, P.J.; Reid, J.M.; Edge, P.J.; Storch, E.A.; Bengtson, M.; Yang, M. Open label aripiprazole in the treatment of youth with tic disorders. J. Child Adolesc. Psychopharmacol., 2009, 19(4), 441-447. [http://dx.doi.org/10.1089/cap.2008.0149]. [PMID: 19702496].
[157]
Connor, K.M.; Payne, V.M.; Gadde, K.M.; Zhang, W.; Davidson, J.R. The use of aripiprazole in obsessive-compulsive disorder: preliminary observations in 8 patients. J. Clin. Psychiatry, 2005, 66(1), 49-51. [http://dx.doi.org/10.4088/JCP.v66n0107]. [PMID: 15669888].
[158]
da Rocha, F.F.; Correa, H. Successful augmentation with aripiprazole in clomipramine-refractory obsessive-compulsive disorder. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2007, 31(7), 1550-1551. [http://dx.doi.org/10.1016/j.pnpbp.2007.07.008]. [PMID: 17692447].
[159]
Sarkar, R.; Klein, J.; Krüger, S. Aripiprazole augmentation in treatment-refractory obsessive-compulsive disorder. Psychopharmacology (Berl.), 2008, 197(4), 687-688. [http://dx.doi.org/ 10.1007/s00213-008-1091-1]. [PMID: 18264798].
[160]
Fornaro, M.; Gabrielli, F.; Mattei, C.; Vinciguerra, V.; Fornaro, P. Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report. Ann. Gen. Psychiatry, 2008, 7, 26. [http://dx.doi.org/10.1186/1744-859X-7-26]. [PMID: 19105842].
[161]
Storch, E.A.; Lehmkuhl, H.; Geffken, G.R.; Touchton, A.; Murphy, T.K. Aripiprazole augmentation of incomplete treatment response in an adolescent male with obsessive-compulsive disorder. Depress. Anxiety, 2008, 25(2), 172-174. [http://dx.doi.org/10.1002/ da.20303]. [PMID: 17340610].
[162]
Pessina, E.; Albert, U.; Bogetto, F.; Maina, G. Aripiprazole augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a 12-week open-label preliminary study. Int. Clin. Psychopharmacol., 2009, 24(5), 265-269. [http:// dx.doi.org/10.1097/YIC.0b013e32832e9b91]. [PMID: 19629012].
[163]
Masi, G.; Pfanner, C.; Millepiedi, S.; Berloffa, S. Aripiprazole augmentation in 39 adolescents with medication-resistant obsessive-compulsive disorder. J. Clin. Psychopharmacol., 2010, 30(6), 688-693. [http://dx.doi.org/10.1097/JCP.0b013e3181fab7b1]. [PMID: 21105283].
[164]
Delle Chiaie, R.; Scarciglia, P.; Pasquini, M.; Caredda, M.; Biondi, M. Aripiprazole augmentation in patients with resistant obsessive compulsive disorder: a pilot study. Clin. Pract. Epidemiol. Ment. Health, 2011, 7, 107-111. [http://dx.doi.org/10.2174/17450179011 07010107]. [PMID: 21686322].
[165]
Matsunaga, H.; Hayashida, K.; Maebayashi, K.; Mito, H.; Kiriike, N. A case series of aripiprazole augmentation of selective serotonin reuptake inhibitors in treatment-refractory obsessive compulsive disorder. Int. J. Psychiatry Clin. Pract., 2011, 15(4), 263-269. [http:// dx.doi.org/10.3109/13651501.2011.605958]. [PMID: 22121999].
[166]
Muscatello, M.R.; Bruno, A.; Pandolfo, G.; Micò, U.; Scimeca, G.; Romeo, V.M.; Santoro, V.; Settineri, S.; Spina, E.; Zoccali, R.A. Effect of aripiprazole augmentation of serotonin reuptake inhibitors or clomipramine in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. J. Clin. Psychopharmacol., 2011, 31(2), 174-179. [http://dx.doi.org/10.1097/JCP. 0b013e31820e3db6]. [PMID: 21346614].
[167]
Sayyah, M.; Sayyah, M.; Boostani, H.; Ghaffari, S.M.; Hoseini, A. Effects of aripiprazole augmentation in treatment-resistant obsessive-compulsive disorder (a double blind clinical trial). Depress. Anxiety, 2012, 29(10), 850-854. [http://dx.doi.org/10.1002/da. 21996]. [PMID: 22933237].
[168]
Leucht, S.; Cipriani, A.; Spineli, L.; Mavridis, D.; Orey, D.; Richter, F.; Samara, M.; Barbui, C.; Engel, R.R.; Geddes, J.R.; Kissling, W.; Stapf, M.P.; Lässig, B.; Salanti, G.; Davis, J.M. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Lancet, 2013, 382(9896), 951-962. [http://dx.doi.org/10.1016/S0140-6736(13)60733-3]. [PMID: 23810019].
[169]
Storch, E.A.; Goddard, A.W.; Grant, J.E.; De Nadai, A.S.; Goodman, W.K.; Mutch, P.J.; Medlock, C.; Odlaug, B.; McDougle, C.J.; Murphy, T.K. Double-blind, placebo-controlled, pilot trial of paliperidone augmentation in serotonin reuptake inhibitor-resistant obsessive-compulsive disorder. J. Clin. Psychiatry, 2013, 74(6), e527-e532. [http://dx.doi.org/10.4088/JCP.12m08278]. [PMID: 23842022].
[170]
McDougle, C.J.; Barr, L.C.; Goodman, W.K.; Pelton, G.H.; Aronson, S.C.; Anand, A.; Price, L.H. Lack of efficacy of clozapine monotherapy in refractory obsessive-compulsive disorder. Am. J. Psychiatry, 1995, 152(12), 1812-1814. [http://dx.doi.org/10.1176/ ajp.152.12.1812]. [PMID: 8526253].
[171]
Englisch, S.; Esslinger, C.; Inta, D.; Weinbrenner, A.; Peus, V.; Gutschalk, A.; Schirmbeck, F.; Zink, M. Clozapine-induced obsessive-compulsive syndromes improve in combination with aripiprazole. Clin. Neuropharmacol., 2009, 32(4), 227-229. [http://dx.doi. org/10.1097/WNF.0b013e31819cc8e6]. [PMID: 19644230].
[172]
Sa, A.R.; Hounie, A.G.; Sampaio, A.S.; Arrais, J.; Miguel, E.C.; Elkis, H. Obsessive-compulsive symptoms and disorder in patients with schizophrenia treated with clozapine or haloperidol. Compr. Psychiatry, 2009, 50(5), 437-442. [http://dx.doi.org/10.1016/j. comppsych.2008.11.005]. [PMID: 19683614].
[173]
Scheltema Beduin, A.A.; Swets, M.; Machielsen, M.; Korver, N. Obsessive-compulsive symptoms in patients with schizophrenia: a naturalistic cross-sectional study comparing treatment with clozapine, olanzapine, risperidone, and no antipsychotics in 543 patients. J. Clin. Psychiatry, 2012, 73(11), 1395-1402. [http://dx.doi.org/10. 4088/JCP.11m07164]. [PMID: 23218156].
[174]
Gahr, M.; Rehbaum, K.; Connemann, B.J. Clozapine-associated development of second-onset obsessive compulsive symptoms in schizophrenia: impact of clozapine serum levels and fluvoxamine add-on. Pharmacopsychiatry, 2014, 47(3), 118-120. [http://dx. doi.org/10.1055/s-0034-1374611]. [PMID: 24846087].
[175]
Grover, S.; Hazari, N.; Chakrabarti, S.; Avasthi, A. Relationship of obsessive compulsive symptoms/disorder with clozapine: A retrospective study from a multispeciality tertiary care centre. Asian J. Psychiatr., 2015, 15, 56-61. [http://dx.doi.org/10.1016/j.ajp.2015. 05.002]. [PMID: 26013671].
[176]
Schirmbeck, F.; Mier, D.; Esslinger, C.; Rausch, F.; Englisch, S.; Eifler, S.; Meyer-Lindenberg, A.; Kirsch, P.; Zink, M. Increased orbitofrontal cortex activation associated with “pro-obsessive” antipsychotic treatment in patients with schizophrenia. J. Psychiatry Neurosci., 2015, 40(2), 89-99. [PMID: 25268790].
[177]
Schirmbeck, F.; Zink, M. Clozapine-induced obsessive-compulsive symptoms in schizophrenia: a critical review. Curr. Neuropharmacol., 2012, 10(1), 88-95. [http://dx.doi.org/10.2174/1570159127 99362724]. [PMID: 22942882].
[178]
Levkovitch, Y.; Kronnenberg, Y.; Gaoni, B. Can clozapine trigger OCD? J. Am. Acad. Child Adolesc. Psychiatry, 1995, 34(3), 263. [http://dx.doi.org/10.1097/00004583-199503000-00005]. [PMID: 7896662].
[179]
Eales, M.J.; Layeni, A.O. Exacerbation of obsessive-compulsive symptoms associated with clozapine. Br. J. Psychiatry, 1994, 164(5), 687-688. [http://dx.doi.org/10.1192/bjp.164.5.687]. [PMID: 7921724].
[180]
Leung, J.G.; Palmer, B.A. Psychosis or Obsessions? Clozapine Associated with Worsening Obsessive-Compulsive Symptoms. Case Rep. Psychiatry, 2016, 20162180748 [http://dx.doi.org/ 10.1155/2016/2180748]. [PMID: 27313938].
[181]
Del Casale, A.; Kotzalidis, G.D.; Rapinesi, C.; Serata, D.; Ambrosi, E.; Simonetti, A.; Pompili, M.; Ferracuti, S.; Tatarelli, R.; Girardi, P. Functional neuroimaging in obsessive-compulsive disorder. Neuropsychobiology, 2011, 64(2), 61-85. [http://dx.doi.org/10. 1159/000325223]. [PMID: 21701225].
[182]
Del Casale, A.; Rapinesi, C.; Kotzalidis, G.D.; De Rossi, P.; Curto, M.; Janiri, D.; Criscuolo, S.; Alessi, M.C.; Ferri, V.R.; De Giorgi, R.; Sani, G.; Ferracuti, S.; Girardi, P.; Brugnoli, R. Executive functions in obsessive-compulsive disorder: An activation likelihood estimate meta-analysis of fMRI studies. World J. Biol. Psychiatry, 2016, 17(5), 378-393. [http://dx.doi.org/10.3109/15622975.2015. 1102323]. [PMID: 26642972].
[183]
Schirmbeck, F.; Esslinger, C.; Rausch, F.; Englisch, S.; Meyer-Lindenberg, A.; Zink, M. Antiserotonergic antipsychotics are associated with obsessive-compulsive symptoms in schizophrenia. Psychol. Med., 2011, 41(11), 2361-2373. [http://dx.doi.org/10.1017/ S0033291711000419]. [PMID: 21466748].
[184]
Cai, J.; Zhang, W.; Yi, Z.; Lu, W.; Wu, Z.; Chen, J.; Yu, S.; Fang, Y.; Zhang, C. Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms. Psychopharmacology (Berl.), 2013, 230(1), 49-55. [http://dx.doi.org/10.1007/s00213-013-3137-2]. [PMID: 23660601].
[185]
Lin, S.K.; Su, S.F.; Pan, C.H. Higher plasma drug concentration in clozapine-treated schizophrenic patients with side effects of obsessive/compulsive symptoms. Ther. Drug Monit., 2006, 28(3), 303-307. [http://dx.doi.org/10.1097/01.ftd.0000211801.66569.80]. [PMID: 16778711].
[186]
Andrade, C. Serotonin reuptake inhibitor treatment of obsessive-compulsive symptoms in clozapine-medicated schizophrenia. J. Clin. Psychiatry, 2012, 73(11), e1362-e1364. [http://dx.doi.org/ 10.4088/JCP.12f08200]. [PMID: 23218164].
[187]
Eryılmaz, G.; Hızlı Sayar, G.; Ozten, E.; Gögcegöz Gül, I.; Karamustafalıoğlu, O. Aripirazole augmentation in clozapine-associated obsessive-compulsive symptoms in schizophrenia. Ann. Gen. Psychiatry, 2013, 12(1), 40. [http://dx.doi.org/10.1186/1744-859X-12-40]. [PMID: 24330737].
[188]
Cassady, S.L.; Thaker, G.K. Addition of fluoxetine to clozapine. Am. J. Psychiatry, 1992, 149(9), 1274. [PMID: 1503143].
[189]
Strous, R.D.; Patel, J.K.; Zimmet, S.; Green, A.I. Clozapine and paroxetine in the treatment of schizophrenia with obsessive-compulsive features. Am. J. Psychiatry, 1999, 156(6), 973-974. [http://dx.doi.org/10.1176/ajp.156.6.973a]. [PMID: 10360153].
[190]
Markowitz, J.S.; Gill, H.S.; Lavia, M.; Brewerton, T.D.; DeVane, C.L. Fluvoxamine-clozapine dose-dependent interaction. Can. J. Psychiatry, 1996, 41(10), 670-671. [http://dx.doi.org/10.1177/ 070674379604101027]. [PMID: 8978949].
[191]
Zink, M.; Englisch, S.; Knopf, U.; Kuwilsky, A.; Dressing, H. Augmentation of clozapine with valproic Acid for clozapine-induced obsessive-compulsive symptoms. Pharmacopsychiatry, 2007, 40(5), 202-203. [http://dx.doi.org/10.1055/s-2007-985885]. [PMID: 17874353].
[192]
Rao, N.P.; Antony, A.; Raveendranathan, D.; Venkatasubramanian, G.; Behere, R.V.; Varambally, S.S.; Gangadhar, B.N. Successful use of maintenance electroconvulsive therapy in the treatment of clozapine-associated obsessive-compulsive symptoms in schizophrenia: a case report. J. ECT, 2011, 27(1), e37-e38. [http://dx. doi.org/10.1097/YCT.0b013e3181ec0d64]. [PMID: 20938347].
[193]
Kapur, S.; Zipursky, R.B.; Remington, G.; Jones, C.; DaSilva, J.; Wilson, A.A.; Houle, S. 5-HT2 and D2 receptor occupancy of olanzapine in schizophrenia: a PET investigation. Am. J. Psychiatry, 1998, 155(7), 921-928. [http://dx.doi.org/10.1176/ajp.155.7.921]. [PMID: 9659858].
[194]
Bloch, M.H.; Landeros-Weisenberger, A.; Kelmendi, B.; Coric, V.; Bracken, M.B.; Leckman, J.F. A systematic review: antipsychotic augmentation with treatment refractory obsessive-compulsive disorder. Mol. Psychiatry, 2006, 11(7), 622-632. [http://dx.doi.org/10. 1038/sj.mp.4001823]. [PMID: 16585942].
[195]
Matsunaga, H.; Nagata, T.; Hayashida, K.; Ohya, K.; Kiriike, N.; Stein, D.J. A long-term trial of the effectiveness and safety of atypical antipsychotic agents in augmenting SSRI-refractory obsessive-compulsive disorder. J. Clin. Psychiatry, 2009, 70(6), 863-868. [http://dx.doi.org/10.4088/JCP.08m04369]. [PMID: 19422759].
[196]
Diniz, J.B.; Shavitt, R.G.; Fossaluza, V.; Koran, L.; Pereira, C.A.; Miguel, E.C. A double-blind, randomized, controlled trial of fluoxetine plus quetiapine or clomipramine versus fluoxetine plus placebo for obsessive-compulsive disorder. J. Clin. Psychopharmacol., 2011, 31(6), 763-768. [http://dx.doi.org/10.1097/JCP. 0b013e3182367aee]. [PMID: 22020357].
[197]
Pallanti, S.; Quercioli, L.; Paiva, R.S.; Koran, L.M. Citalopram for treatment-resistant obsessive-compulsive disorder. Eur. Psychiatry, 1999, 14(2), 101-106. [http://dx.doi.org/10.1016/S0924-9338(99) 80725-1]. [PMID: 10572334].
[198]
Neuvonen, P.J.; Pohjola-Sintonen, S.; Tacke, U.; Vuori, E. Five fatal cases of serotonin syndrome after moclobemide-citalopram or moclobemide-clomipramine overdoses. Lancet, 1993, 342(8884), 1419. [http://dx.doi.org/10.1016/0140-6736(93)92774-N]. [PMID: 7901695].
[199]
Rosebush, P.I.; Margetts, P.; Mazurek, M.F. Serotonin syndrome as a result of clomipramine monotherapy. J. Clin. Psychopharmacol., 1999, 19(3), 285-287. [http://dx.doi.org/10.1097/00004714-199906000-00021]. [PMID: 10350043].
[200]
Carey, P.D.; Lochner, C.; Kidd, M.; Van Ameringen, M.; Stein, D.J.; Denys, D. Quetiapine augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: is response to treatment predictable? Int. Clin. Psychopharmacol., 2012, 27(6), 321-325. [PMID: 22859064].
[201]
Berlin, H.A.; Koran, L.M.; Jenike, M.A.; Shapira, N.A.; Chaplin, W.; Pallanti, S.; Hollander, E. Double-blind, placebo-controlled trial of topiramate augmentation in treatment-resistant obsessive-compulsive disorder. J. Clin. Psychiatry, 2011, 72(5), 716-721. [http://dx.doi.org/10.4088/JCP.09m05266gre]. [PMID: 20816027].
[202]
Mowla, A.; Khajeian, A.M.; Sahraian, A.; Chohedri, A.H.; Kashkoli, F. Topiramate Augmentation in Resistant OCD: A Double-Blind Placebo-Controlled Clinical Trial. CNS Spectr., 2010, 15(11), 613-617. [http://dx.doi.org/10.1017/S1092852912000065]. [PMID: 24726048].
[203]
Rubio, A.; Jiménez-Arriero, M.A.; Martínez-Gras, I.; Manzanares, J.; Palomo , T. The effects of topiramate adjunctive treatment addedto antidepressants in patients with resistant obsessive-compulsive disorder. J. Clin. Psychopharmacol.., 2006, 26(3), 341-344. [PMID: 16702907].
[204]
Afshar, H.; Akuchekian, S.; Mahaky, B.; Zarean, E. Topiramate augmentation in refractory obsessive-compulsive disorder: A randomized, double-blind, placebo-controlled trial. J. Res. Med. Sci., 2014, 19(10), 976-981. [PMID: 25538783].
[205]
Oulis, P.; Mourikis, I.; Konstantakopoulos, G. Pregabalin augmentation in treatment-resistant obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2011, 26(4), 221-224. [http://dx.doi. org/10.1097/YIC.0b013e3283466657]. [PMID: 21460732].
[206]
Uzun, O. Lamotrigine as an augmentation agent in treatment-resistant obsessive-compulsive disorder: a case report. J. Psychopharmacol. (Oxford), 2010, 24(3), 425-427. [http://dx.doi.org/ 10.1177/0269881108098809]. [PMID: 19010977].
[207]
Arrojo-Romero, M.; Tajes, A.M.; de Leon, J. Lamotrigine augmentation of serotonin reuptake inhibitors in severe and long-term treatment-resistant obsessive-compulsive disorder. Case Rep. Psychiatry, 2013, 2013612459 [http://dx.doi.org/10.1155/2013/ 612459]. [PMID: 23936714].
[208]
Bruno, A.; Micò, U.; Pandolfo, G.; Mallamace, D.; Abenavoli, E.; Di Nardo, F.; D’Arrigo, C.; Spina, E.; Zoccali, R.A.; Muscatello, M.R. Lamotrigine augmentation of serotonin reuptake inhibitors in treatment-resistant obsessive-compulsive disorder: a double-blind, placebo-controlled study. J. Psychopharmacol. (Oxford), 2012, 26(11), 1456-1462. [http://dx.doi.org/10.1177/0269881111431751]. [PMID: 22351381].
[209]
Khalkhali, M.; Aram, S.; Zarrabi, H.; Kafie, M.; Heidarzadeh, A. Lamotrigine augmentation versus placebo in serotonin reuptake inhibitors-resistant obsessive-compulsive disorder: a randomized controlled trial. Iran. J. Psychiatry, 2016, 11(2), 104-114. [PMID: 27437007].
[210]
Onder, E.; Tural, U.; Gökbakan, M. Does gabapentin lead to early symptom improvement in obsessive-compulsive disorder? Eur. Arch. Psychiatry Clin. Neurosci., 2008, 258(6), 319-323. [http:// dx.doi.org/10.1007/s00406-007-0798-z]. [PMID: 18297416].
[211]
Deltito, J.A. Valproate pretreatment for the difficult-to-treat patient with OCD. J. Clin. Psychiatry, 1994, 55(11), 500. [PMID: 7989288].
[212]
Corá-Locatelli, G.; Greenberg, B.D.; Martin, J.D.; Murphy, D.L. Valproate monotherapy in an SRI-intolerant OCD patient. J. Clin. Psychiatry, 1998, 59(2), 82. [http://dx.doi.org/10.4088/JCP.v59n0207b]. [PMID: 9501891].
[213]
Thompson, A.J.; Lummis, S.C. The 5-HT3 receptor as a therapeutic target. Expert Opin. Ther. Targets, 2007, 11(4), 527-540. [http://dx.doi.org/10.1517/14728222.11.4.527]. [PMID: 17373882].
[214]
Andrade, C. Nonsteroidal anti-inflammatory drugs and 5-HT3 serotonin receptor antagonists as innovative antipsychotic augmentation treatments for schizophrenia. J. Clin. Psychiatry, 2014, 75(7), e707-e709. [http://dx.doi.org/10.4088/JCP.14f09292]. [PMID: 25093487].
[215]
Toren, P.; Weizman, A.; Ratner, S.; Cohen, D.; Laor, N. Ondansetron treatment in Tourette’s disorder: a 3-week, randomized, double-blind, placebo-controlled study. J. Clin. Psychiatry, 2005, 66(4), 499-503. [http://dx.doi.org/10.4088/JCP.v66n0413]. [PMID: 15816793].
[216]
Sirota, P.; Mosheva, T.; Shabtay, H.; Giladi, N.; Korczyn, A.D. Use of the selective serotonin 3 receptor antagonist ondansetron in the treatment of neuroleptic-induced tardive dyskinesia. Am. J. Psychiatry, 2000, 157(2), 287-289. [http://dx.doi.org/10.1176/appi. ajp.157.2.287]. [PMID: 10671405].
[217]
Johnson, B.A.; Ait-Daoud, N.; Seneviratne, C.; Roache, J.D.; Javors, M.A.; Wang, X.Q.; Liu, L.; Penberthy, J.K.; DiClemente, C.C.; Li, M.D. Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am. J. Psychiatry, 2011, 168(3), 265-275. [http://dx.doi.org/ 10.1176/appi.ajp.2010.10050755]. [PMID: 21247998].
[218]
Serata, D.; Kotzalidis, G.D.; Rapinesi, C.; Janiri, D.; Di Pietro, S.; Callovini, G.; Piacentino, D.; Gasperoni, C.; Brugnoli, R.; Ferri, V.R.; Girardi, N.; Tatarelli, R.; Ferracuti, S.; Angeletti, G.; Girardi, P.; Del Casale, A. Are 5-HT3 antagonists effective in obsessive-compulsive disorder? A systematic review of literature. Hum. Psychopharmacol., 2015, 30(2), 70-84. [http://dx.doi.org/10.1002/ hup.2461]. [PMID: 25676060].
[219]
Hewlett, W.A.; Schmid, S.P.; Salomon, R.M. Pilot trial of ondansetron in the treatment of 8 patients with obsessive-compulsive disorder. J. Clin. Psychiatry, 2003, 64(9), 1025-1030. [http://dx.doi.org/ 10.4088/JCP.v64n0907]. [PMID: 14628977].
[220]
Pallanti, S.; Bernardi, S.; Antonini, S.; Singh, N.; Hollander, E. Ondansetron augmentation in treatment-resistant obsessive-compulsive disorder: a preliminary, single-blind, prospective study. CNS Drugs, 2009, 23(12), 1047-1055. [http://dx.doi.org/10.2165/ 11530240-000000000-00000]. [PMID: 19958042].
[221]
Pallanti, S.; Bernardi, S.; Antonini, S.; Singh, N.; Hollander, E. Ondansetron augmentation in patients with obsessive-compulsive disorder who are inadequate responders to serotonin reuptake inhibitors: improvement with treatment and worsening following discontinuation. Eur. Neuropsychopharmacol., 2014, 24(3), 375-380. [http://dx.doi.org/10.1016/j.euroneuro.2013.12.003]. [PMID: 24406025].
[222]
Soltani, F.; Sayyah, M.; Feizy, F.; Malayeri, A.; Siahpoosh, A.; Motlagh, I. A double-blind, placebo-controlled pilot study of ondansetron for patients with obsessive-compulsive disorder. Hum. Psychopharmacol., 2010, 25(6), 509-513. [http://dx.doi.org/10. 1002/hup.1145]. [PMID: 20737524].
[223]
Heidari, M.; Zarei, M.; Hosseini, S.M.; Taghvaei, R.; Maleki, H.; Tabrizi, M.; Fallah, J.; Akhondzadeh, S. Ondansetron or placebo in the augmentation of fluvoxamine response over 8 weeks in obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2014, 29(6), 344-350. [http://dx.doi.org/10.1097/YIC.0000000000000043]. [PMID: 24850229].
[224]
Andrade, C. Ondansetron augmentation of serotonin reuptake inhibitors as a treatment strategy in obsessive-compulsive disorder. J. Clin. Psychiatry, 2015, 76(1), e72-e75. [http://dx.doi.org/ 10.4088/JCP.14f09704]. [PMID: 25650682].
[225]
Shapira, N.A.; Keck, P.E., Jr; Goldsmith, T.D.; McConville, B.J.; Eis, M.; McElroy, S.L. Open-label pilot study of tramadol hydrochloride in treatment-refractory obsessive-compulsive disorder. Depress. Anxiety, 1997, 6(4), 170-173. [http://dx.doi.org/10.1002/ (SICI)1520-6394(1997)6:4<170:AID-DA7>3.0.CO;2-G]. [PMID: 9559288].
[226]
Warneke, L. A possible new treatment approach to obsessive-compulsive disorder. Can. J. Psychiatry, 1997, 42(6), 667-668. [http://dx.doi.org/10.1177/070674379704200624]. [PMID: 9288436].
[227]
Goldsmith, T.B.; Shapira, N.A.; Keck, P.E. Jr Rapid remission of OCD with tramadol hydrochloride. Am. J. Psychiatry, 1999, 156(4), 660-661. [PMID: 10200754].
[228]
Koran, L.M.; Aboujaoude, E.; Bullock, K.D.; Franz, B.; Gamel, N.; Elliott, M. Double-blind treatment with oral morphine in treatment-resistant obsessive-compulsive disorder. J. Clin. Psychiatry, 2005, 66(3), 353-359. [http://dx.doi.org/10.4088/JCP.v66n0312]. [PMID: 15766302].
[229]
Liddell, M.B.; Aziz, V.; Briggs, P.; Kanakkehewa, N.; Rawi, O. Buprenorphine augmentation in the treatment of refractory obsessive-compulsive disorder. Ther. Adv. Psychopharmacol., 2013, 3(1), 15-19. [http://dx.doi.org/10.1177/2045125312462233]. [PMID: 23983988].
[230]
Urraca, N.; Camarena, B.; Gómez-Caudillo, L.; Esmer, M.C.; Nicolini, H. Mu opioid receptor gene as a candidate for the study of obsessive compulsive disorder with and without tics. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 2004, 127B(1), 94-96. [http://dx. doi.org/10.1002/ajmg.b.20170]. [PMID: 15108189].
[231]
Rojas-Corrales, M.O.; Gibert-Rahola, J.; Mico, J.A. Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior. Psychopharmacology (Berl.), 2007, 190(2), 221-231. [http://dx.doi.org/10.1007/s00213-006-0619-5]. [PMID: 17102981].
[232]
Insel, T.R.; Pickar, D. Naloxone administration in obsessive-compulsive disorder: report of two cases. Am. J. Psychiatry, 1983, 140(9), 1219-1220. [http://dx.doi.org/10.1176/ajp.140.9.1219]. [PMID: 6614234].
[233]
Keuler, D.J.; Altemus, M.; Michelson, D.; Greenberg, B.; Murphy, D.L. Behavioral effects of naloxone infusion in obsessive-compulsive disorder. Biol. Psychiatry, 1996, 40(2), 154-156. [http:// dx.doi.org/10.1016/0006-3223(95)00632-X]. [PMID: 8793049].
[234]
Goff, D.C.; Tsai, G.; Levitt, J.; Amico, E.; Manoach, D.; Schoenfeld, D.A.; Hayden, D.L.; McCarley, R.; Coyle, J.T. A placebo-controlled trial of D-cycloserine added to conventional neuroleptics in patients with schizophrenia. Arch. Gen. Psychiatry, 1999, 56(1), 21-27. [http://dx.doi.org/10.1001/archpsyc.56.1.21]. [PMID: 9892252].
[235]
Tsai, G.E.; Falk, W.E.; Gunther, J.; Coyle, J.T. Improved cognition in Alzheimer’s disease with short-term D-cycloserine treatment. Am. J. Psychiatry, 1999, 156(3), 467-469. [PMID: 10080566].
[236]
Otto, M.W.; Basden, S.L.; Leyro, T.M.; McHugh, R.K.; Hofmann, S.G. Clinical perspectives on the combination of D-cycloserine and cognitive-behavioral therapy for the treatment of anxiety disorders. CNS Spectr., 2007, 12(1), 51-56, 59-61. [http://dx.doi.org/10.1017/ S1092852900020526]. [PMID: 17192764].
[237]
Walker, D.L.; Ressler, K.J.; Lu, K.T.; Davis, M. Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. J. Neurosci., 2002, 22(6), 2343-2351. [http://dx.doi.org/10.1523/JNEUROSCI.22-06-02343.2002]. [PMID: 11896173].
[238]
Norberg, M.M.; Krystal, J.H.; Tolin, D.F. A meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapy. Biol. Psychiatry, 2008, 63(12), 1118-1126. [http://dx.doi. org/10.1016/j.biopsych.2008.01.012]. [PMID: 18313643].
[239]
Rodrigues, H.; Figueira, I.; Lopes, A.; Gonçalves, R.; Mendlowicz, M.V.; Coutinho, E.S.; Ventura, P. Does D-cycloserine enhance exposure therapy for anxiety disorders in humans? A meta-analysis. PLoS One, 2014, 9(7)e93519 [http://dx.doi.org/10.1371/journal. pone.0093519]. [PMID: 24991926].
[240]
Andersson, E.; Hedman, E.; Enander, J.; Radu, D.D.; Ljótsson, B.; Cervenka, S.; Isung, J.; Svanborg, C.; Mataix-Cols, D.; Kaldo, V.; Andersson, G.; Lindefors, N.; Rück, C. D-cycloserine vs. placebo as adjunct to cognitive behavioral therapy for obsessive-compulsive disorder and interaction with antidepressants: A randomized clinical trial. JAMA Psychiatry, 2015, 72(7), 659-667. [http://dx.doi.org/10.1001/jamapsychiatry.2015.0546]. [PMID: 25970252].
[241]
Werner-Seidler, A.; Richardson, R. Effects of D-cycloserine on extinction: consequences of prior exposure to imipramine. Biol. Psychiatry, 2007, 62(10), 1195-1197. [DOI:10.1016/j.biopsych. 2007.04.010]. [PMID: 17555721].
[242]
Mataix-Cols, D.; Fernández de la Cruz, L.; Monzani, B.; Rosenfield, D.; Andersson, E.; Pérez-Vigil, A.; Frumento, P.; de Kleine, R.A.; Difede, J.; Dunlop, B.W.; Farrell, L.J.; Geller, D.; Gerardi, M.; Guastella, A.J.; Hofmann, S.G.; Hendriks, G.J.; Kushner, M.G.; Lee, F.S.; Lenze, E.J.; Levinson, C.A.; McConnell, H.; Otto, M.W.; Plag, J.; Pollack, M.H.; Ressler, K.J.; Rodebaugh, T.L.; Rothbaum, B.O.; Scheeringa, M.S.; Siewert-Siegmund, A.; Smits, J.A.J.; Storch, E.A.; Ströhle, A.; Tart, C.D.; Tolin, D.F.; van Minnen, A.; Waters, A.M.; Weems, C.F.; Wilhelm, S.; Wyka, K.; Davis, M.; Rück, C.; Altemus, M.; Anderson, P.; Cukor, J.; Finck, C.; Geffken, G.R.; Golfels, F.; Goodman, W.K.; Gutner, C.; Heyman, I.; Jovanovic, T.; Lewin, A.B.; McNamara, J.P.; Murphy, T.K.; Norrholm, S.; Thuras, P. D-Cycloserine Augmentation of Exposure-Based Cognitive Behavior Therapy for Anxiety, Obsessive-Compulsive, and Posttraumatic Stress Disorders: A Systematic Review and Meta-analysis of Individual Participant Data. JAMA Psychiatry, 2017, 74(5), 501-510. [http://dx.doi.org/10.1001/ jamapsychiatry.2016.3955]. [PMID: 28122091].
[243]
Kushner, M.G.; Kim, S.W.; Donahue, C.; Thuras, P.; Adson, D.; Kotlyar, M.; McCabe, J.; Peterson, J.; Foa, E.B. D-cycloserine augmented exposure therapy for obsessive-compulsive disorder. Biol. Psychiatry, 2007, 62(8), 835-838. [http://dx.doi.org/10.1016/j. biopsych.2006.12.020]. [PMID: 17588545].
[244]
Storch, E.A.; Merlo, L.J.; Bengtson, M.; Murphy, T.K.; Lewis, M.H.; Yang, M.C.; Jacob, M.L.; Larson, M.; Hirsh, A.; Fernandez, M.; Geffken, G.R.; Goodman, W.K. D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2007, 22(4), 230-237. [http:// dx.doi.org/10.1097/YIC.0b013e32819f8480]. [PMID: 17519647].
[245]
Wilhelm, S.; Buhlmann, U.; Tolin, D.F.; Meunier, S.A.; Pearlson, G.D.; Reese, H.E.; Cannistraro, P.; Jenike, M.A.; Rauch, S.L. Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder. Am. J. Psychiatry, 2008, 165(3), 335-341. [http://dx.doi.org/10.1176/appi.ajp.2007.07050776]. [PMID: 18245177].
[246]
Storch, E.A.; Murphy, T.K.; Goodman, W.K.; Geffken, G.R.; Lewin, A.B.; Henin, A.; Micco, J.A.; Sprich, S.; Wilhelm, S.; Bengtson, M.; Geller, D.A. A preliminary study of D-cycloserine augmentation of cognitive-behavioral therapy in pediatric obsessive-compulsive disorder. Biol. Psychiatry, 2010, 68(11), 1073-1076. [http://dx.doi.org/10.1016/j.biopsych.2010.07.015]. [PMID: 20817153].
[247]
Mataix-Cols, D.; Turner, C.; Monzani, B.; Isomura, K.; Murphy, C.; Krebs, G.; Heyman, I. Cognitive-behavioural therapy with post-session D-cycloserine augmentation for paediatric obsessive-compulsive disorder: pilot randomised controlled trial. Br. J. Psychiatry, 2014, 204(1), 77-78. [http://dx.doi.org/10.1192/bjp.bp.113. 126284]. [PMID: 24262813].
[248]
Chasson, G.S.; Buhlmann, U.; Tolin, D.F.; Rao, S.R.; Reese, H.E.; Rowley, T.; Welsh, K.S.; Wilhelm, S. Need for speed: evaluating slopes of OCD recovery in behavior therapy enhanced with d-cycloserine. Behav. Res. Ther., 2010, 48(7), 675-679. [http://dx. doi.org/10.1016/j.brat.2010.03.007]. [PMID: 20362975].
[249]
Ganasen, K.A.; Ipser, J.C.; Stein, D.J. Augmentation of cognitive behavioral therapy with pharmacotherapy. Psychiatr. Clin. North Am., 2010, 33(3), 687-699. [http://dx.doi.org/10.1016/j.psc.2010. 04.008]. [PMID: 20599140].
[250]
Bontempo, A.; Panza, K.E.; Bloch, M.H. D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders: a meta-analysis. J. Clin. Psychiatry, 2012, 73(4), 533-537. [http://dx.doi.org/10.4088/JCP.11r07356]. [PMID: 22579153].
[251]
Hofmann, S.G.; Pollack, M.H.; Otto, M.W. Augmentation treatment of psychotherapy for anxiety disorders with D-cycloserine. CNS Drug Rev., 2006, 12(3-4), 208-217. [http://dx.doi.org/10. 1111/j.1527-3458.2006.00208.x]. [PMID: 17227287].
[252]
de Kleine, R.A.; Hendriks, G.J.; Kusters, W.J.; Broekman, T.G.; van Minnen, A. A randomized placebo-controlled trial of D-cycloserine to enhance exposure therapy for posttraumatic stress disorder. Biol. Psychiatry, 2012, 71(11), 962-968. [http://dx. doi.org/10.1016/j.biopsych.2012.02.033]. [PMID: 22480663].
[253]
D’Souza, D.C.; Gil, R.; Cassello, K.; Morrissey, K.; Abi-Saab, D.; White, J.; Sturwold, R.; Bennett, A.; Karper, L.P.; Zuzarte, E.; Charney, D.S.; Krystal, J.H. IV glycine and oral D-cycloserine effects on plasma and CSF amino acids in healthy humans. Biol. Psychiatry, 2000, 47(5), 450-462. [http://dx.doi.org/10.1016/S0006-3223(99)00133-X]. [PMID: 10704956].
[254]
Quartermain, D.; Mower, J.; Rafferty, M.F.; Herting, R.L.; Lanthorn, T.H. Acute but not chronic activation of the NMDA-coupled glycine receptor with D-cycloserine facilitates learning and retention. Eur. J. Pharmacol., 1994, 257(1-2), 7-12. [http://dx.doi. org/10.1016/0014-2999(94)90687-4]. [PMID: 8082709].
[255]
Boje, K.M.; Wong, G.; Skolnick, P. Desensitization of the NMDA receptor complex by glycinergic ligands in cerebellar granule cell cultures. Brain Res., 1993, 603(2), 207-214. [http://dx.doi.org/10. 1016/0006-8993(93)91239-O]. [PMID: 8096423].
[256]
de Leeuw, A.S.; van Megen, H.J.; Kahn, R.S.; Westenberg, H.G. d-cycloserine addition to exposure sessions in the treatment of patients with obsessive-compulsive disorder. Eur. Psychiatry, 2017, 40, 38-44. [http://dx.doi.org/10.1016/j.eurpsy.2016.06.011]. [PMID: 27837671].
[257]
Marsicano, G.; Wotjak, C.T.; Azad, S.C.; Bisogno, T.; Rammes, G.; Cascio, M.G.; Hermann, H.; Tang, J.; Hofmann, C.; Zieglgänsberger, W.; Di Marzo, V.; Lutz, B. The endogenous cannabinoid system controls extinction of aversive memories. Nature, 2002, 418(6897), 530-534. [http://dx.doi.org/10.1038/nature00839]. [PMID: 12152079].
[258]
Evanson, N.K.; Tasker, J.G.; Hill, M.N.; Hillard, C.J.; Herman, J.P. Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. Endocrinology, 2010, 151(10), 4811-4819. [http://dx.doi.org/10.1210/en.2010-0285]. [PMID: 20702575].
[259]
Abush, H.; Akirav, I. Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory. Neuropsychopharmacology, 2013, 38(8), 1521-1534. [http:// dx.doi.org/10.1038/npp.2013.51]. [PMID: 23426383].
[260]
Micale, V.; Di Marzo, V.; Sulcova, A.; Wotjak, C.T.; Drago, F. Endocannabinoid system and mood disorders: priming a target for new therapies. Pharmacol. Ther., 2013, 138(1), 18-37. [http://dx. doi.org/10.1016/j.pharmthera.2012.12.002]. [PMID: 23261685].
[261]
Schier, A.R.; Ribeiro, N.P.; Silva, A.C.; Hallak, J.E.; Crippa, J.A.; Nardi, A.E.; Zuardi, A.W. Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug. Rev. Bras. Psiquiatr., 2012, 34(Suppl. 1), S104-S110. [http://dx.doi.org/10.1016/S1516-4446(12)70057-0]. [PMID: 22729452].
[262]
Papini, S.; Sullivan, G.M.; Hien, D.A.; Shvil, E.; Neria, Y. Toward a translational approach to targeting the endocannabinoid system in posttraumatic stress disorder: a critical review of preclinical research. Biol. Psychol., 2015, 104, 8-18. [http://dx.doi.org/10.1016/j. biopsycho.2014.10.010]. [PMID: 25448242].
[263]
Blessing, E.M.; Steenkamp, M.M.; Manzanares, J.; Marmar, C.R. Cannabidiol as a potential treatment for anxiety disorders. Neurotherapeutics, 2015, 12(4), 825-836. [http://dx.doi.org/10.1007/ s13311-015-0387-1]. [PMID: 26341731].
[264]
Martinotti, G.; Di Iorio, G.; Sepede, G.; De Berardis, D.; De Risio, L.; Di Giannantonio, M. Cannabis use and psychosis: theme introduction. Curr. Pharm. Des., 2012, 18(32), 4991-4998. [http://dx. doi.org/10.2174/138161212802884627]. [PMID: 22716149].
[265]
Rutrick, D.; Stein, D.J.; Subramanian, G.; Smith, B.; Fava, M.; Hasler, G.; Cha, J.H.; Gasparini, F.; Donchev, T.; Ocwieja, M.; Johns, D.; Gomez-Mancilla, B. Mavoglurant augmentation in OCD patients resistant to selective serotonin reuptake inhibitors: a proof-of-concept, randomized, placebo-controlled, phase 2 study. Adv. Ther., 2017, 34(2), 524-541. [http://dx.doi.org/10.1007/s12325-016-0468-5]. [PMID: 28044255].
[266]
Fux, M.; Benjamin, J.; Nemets, B. A placebo-controlled cross-over trial of adjunctive EPA in OCD. J. Psychiatr. Res., 2004, 38(3), 323-325. [http://dx.doi.org/10.1016/S0022-3956(03)00077-3]. [PMID: 15003438].
[267]
Sayyah, M.; Boostani, H.; Pakseresht, S.; Malayeri, A. A preliminary randomized double-blind clinical trial on the efficacy of celecoxib as an adjunct in the treatment of obsessive-compulsive disorder. Psychiatry Res., 2011, 189(3), 403-406. [http://dx.doi.org/ 10.1016/j.psychres.2011.01.019]. [PMID: 21329988].
[268]
Arabzadeh, S.; Shahhossenie, M.; Mesgarpour, B.; Rezaei, F.; Shalbafan, M.R.; Ghiasi, Z.; Akhondzadeh, S. L-carnosine as an adjuvant to fluvoxamine in treatment of obsessive compulsive disorder: A randomized double-blind study. Hum. Psychopharmacol., 2017, 32(4) [http://dx.doi.org/10.1002/hup.2584]. [PMID: 28485008].
[269]
Fux, M.; Levine, J.; Aviv, A.; Belmaker, R.H. Inositol treatment of obsessive-compulsive disorder. Am. J. Psychiatry, 1996, 153(9), 1219-1221. [http://dx.doi.org/10.1176/ajp.153.9.1219]. [PMID: 8780431].
[270]
Askari, N.; Moin, M.; Sanati, M.; Tajdini, M.; Hosseini, S.M.; Modabbernia, A.; Najand, B.; Salimi, S.; Tabrizi, M.; Ashrafi, M.; Hajiaghaee, R.; Akhondzadeh, S. Granisetron adjunct to fluvoxamine for moderate to severe obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial. CNS Drugs, 2012, 26(10), 883-892. [http://dx.doi.org/10.2165/11635850-000000000-00000]. [PMID: 22873680].
[271]
Dannon, P.N.; Sasson, Y.; Hirschmann, S.; Iancu, I.; Grunhaus, L.J.; Zohar, J. Pindolol augmentation in treatment-resistant obsessive compulsive disorder: a double-blind placebo controlled trial. Eur. Neuropsychopharmacol., 2000, 10(3), 165-169. [http://dx.doi. org/10.1016/S0924-977X(00)00065-1]. [PMID: 10793318].
[272]
Ghaleiha, A.; Entezari, N.; Modabbernia, A.; Najand, B.; Askari, N.; Tabrizi, M.; Ashrafi, M.; Hajiaghaee, R.; Akhondzadeh, S. Memantine add-on in moderate to severe obsessive-compulsive disorder: randomized double-blind placebo-controlled study. J. Psychiatr. Res., 2013, 47(2), 175-180. [http://dx.doi.org/10.1016/j. jpsychires.2012.09.015]. [PMID: 23063327].
[273]
Haghighi, M.; Jahangard, L.; Mohammad-Beigi, H.; Bajoghli, H.; Hafezian, H.; Rahimi, A.; Afshar, H.; Holsboer-Trachsler, E.; Brand, S. In a double-blind, randomized and placebo-controlled trial, adjuvant memantine improved symptoms in inpatients suffering from refractory obsessive-compulsive disorders (OCD). Psychopharmacology (Berl.), 2013, 228(4), 633-640. [http://dx.doi. org/10.1007/s00213-013-3067-z]. [PMID: 23525525].
[274]
Modarresi, A.; Sayyah, M.; Razooghi, S.; Eslami, K.; Javadi, M.; Kouti, L. Memantine augmentation improves symptoms in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a randomized controlled trial. Pharmacopsychiatry, 2018, 51(6), 263-269. Epub ahead of print [http://dx.doi.org/10.1055/s-0043-120268]. [PMID: 29100251].
[275]
Sarris, J.; Oliver, G.; Camfield, D.A.; Dean, O.M.; Dowling, N.; Smith, D.J.; Murphy, J.; Menon, R.; Berk, M.; Blair-West, S.; Ng, C.H. Menon.; R.; Berk, M.; Blair-West, S.; Ng, C.H. N-acetyl cysteine (NAC) in the treatment of obsessive-compulsive disorder: a 16-week, double-blind, randomised, placebo-controlled study. CNS Drugs, 2015, 29(9), 801-809. [http://dx.doi.org/10.1007/s40263-015-0272-9]. [PMID: 26374743].
[276]
Afshar, H.; Roohafza, H.; Mohammad-Beigi, H.; Haghighi, M.; Jahangard, L.; Shokouh, P.; Sadeghi, M.; Hafezian, H. N-acetylcysteine add-on treatment in refractory obsessive-compulsive disorder: a randomized, double-blind, placebo-controlled trial. J. Clin. Psychopharmacol., 2012, 32(6), 797-803. [http://dx.doi.org/ 10.1097/JCP.0b013e318272677d]. [PMID: 23131885].
[277]
Paydary, K.; Akamaloo, A.; Ahmadipour, A.; Pishgar, F.; Emamzadehfard, S.; Akhondzadeh, S. N-acetylcysteine augmentation therapy for moderate-to-severe obsessive-compulsive disorder: randomized, double-blind, placebo-controlled trial. J. Clin. Pharm. Ther., 2016, 41(2), 214-219. [http://dx.doi.org/10.1111/jcpt.12370]. [PMID: 26931055].
[278]
Costa, D.L.C.; Diniz, J.B.; Requena, G.; Joaquim, M.A.; Pittenger, C.; Bloch, M.H.; Miguel, E.C.; Shavitt, R.G. Randomized, double-blind, placebo-controlled trial of N-acetylcysteine augmentation for treatment-resistant obsessive-compulsive disorder. J. Clin. Psychiatry, 2017, 78(7), e766-e773. [http://dx.doi.org/10.4088/JCP. 16m11101]. [PMID: 28617566].
[279]
Grady, T.A.; Pigott, T.A.; L’Heureux, F.; Hill, J.L.; Bernstein, S.E.; Murphy, D.L. Double-blind study of adjuvant buspirone for fluoxetine-treated patients with obsessive-compulsive disorder. Am. J. Psychiatry, 1993, 150(5), 819-821. [http://dx.doi.org/10.1176/ ajp.150.5.819]. [PMID: 8480832].
[280]
McDougle, C.J.; Goodman, W.K.; Leckman, J.F.; Holzer, J.C.; Barr, L.C.; McCance-Katz, E.; Heninger, G.R.; Price, L.H. Limited therapeutic effect of addition of buspirone in fluvoxamine-refractory obsessive-compulsive disorder. Am. J. Psychiatry, 1993, 150(4), 647-649. [http://dx.doi.org/10.1176/ajp.150.4.647]. [PMID: 8465885].
[281]
Hollander, E.; Kaplan, A.; Stahl, S.M. A double-blind, placebo-controlled trial of clonazepam in obsessive-compulsive disorder. World J. Biol. Psychiatry, 2003, 4(1), 30-34. [http://dx.doi.org/10. 3109/15622970309167908]. [PMID: 12582975].
[282]
Greenberg, W.M.; Benedict, M.M.; Doerfer, J.; Perrin, M.; Panek, L.; Cleveland, W.L.; Javitt, D.C. Adjunctive glycine in the treatment of obsessive-compulsive disorder in adults. J. Psychiatr. Res., 2009, 43(6), 664-670. [http://dx.doi.org/10.1016/j.jpsychires. 2008.10.007]. [PMID: 19046587].
[283]
McDougle, C.J.; Price, L.H.; Goodman, W.K.; Charney, D.S.; Heninger, G.R. A controlled trial of lithium augmentation in fluvoxamine-refractory obsessive-compulsive disorder: lack of efficacy. J. Clin. Psychopharmacol., 1991, 11(3), 175-184. [http://dx. doi.org/10.1097/00004714-199106000-00005]. [PMID: 1820757].
[284]
Amiaz, R.; Fostick, L.; Gershon, A.; Zohar, J. Naltrexone augmentation in OCD: a double-blind placebo-controlled cross-over study. Eur. Neuropsychopharmacol., 2008, 18(6), 455-461. [http://dx. doi.org/10.1016/j.euroneuro.2008.01.006]. [PMID: 18353618].
[285]
Pittenger, C.; Bloch, M.H.; Wasylink, S.; Billingslea, E.; Simpson, R.; Jakubovski, E.; Kelmendi, B.; Sanacora, G.; Coric, V. Riluzole augmentation in treatment-refractory obsessive-compulsive disorder: a pilot randomized placebo-controlled trial. J. Clin. Psychiatry, 2015, 76(8), 1075-1084. [http://dx.doi.org/10.4088/JCP.14m09123]. [PMID: 26214725].
[286]
Besiroglu, L.; Agargun, M.Y.; Ozbebit, O.; Aydin, A. A discrimination based on autogenous versus reactive obsessions in obsessive-compulsive disorder and related clinical manifestations. CNS Spectr., 2006, 11(3), 179-186. [http://dx.doi.org/10.1017/ S1092852900014292]. [PMID: 16575374].
[287]
Lee, H.J.; Kwon, S.M. Two different types of obsession: autogenous obsessions and reactive obsessions. Behav. Res. Ther., 2003, 41(1), 11-29. [http://dx.doi.org/10.1016/S0005-7967(01)00101-2]. [PMID: 12488117].
[288]
Lee, H.J.; Telch, M.J. Autogenous/reactive obsessions and their relationship with OCD symptoms and schizotypal personality features. J. Anxiety Disord., 2005, 19(7), 793-805. [http://dx.doi.org/ 10.1016/j.janxdis.2004.10.001]. [PMID: 16076425].
[289]
Besiroglu, L.; Sozen, M.; Ozbebit, O.; Avcu, S.; Selvi, Y.; Bora, A.; Atli, A.; Unal, O.; Bulut, M.D. The involvement of distinct neural systems in patients with obsessive-compulsive disorder with autogenous and reactive obsessions. Acta Psychiatr. Scand., 2011, 124(2), 141-151. [http://dx.doi.org/10.1111/j.1600-0447.2011. 01726.x]. [PMID: 21627621].
[290]
Subirà, M.; Alonso, P.; Segalàs, C.; Real, E.; López-Solà, C.; Pujol, J.; Martínez-Zalacaín, I.; Harrison, B.J.; Menchón, J.M.; Cardoner, N.; Soriano-Mas, C. Brain structural alterations in obsessive-compulsive disorder patients with autogenous and reactive obsessions. PLoS One, 2013, 8(9)e75273 [http://dx.doi.org/10.1371/ journal.pone.0075273]. [PMID: 24098688].
[291]
Rufer, M.; Fricke, S.; Moritz, S.; Kloss, M.; Hand, I. Symptom dimensions in obsessive-compulsive disorder: prediction of cognitive-behavior therapy outcome. Acta Psychiatr. Scand., 2006, 113(5), 440-446. [http://dx.doi.org/10.1111/j.1600-0447.2005.0 0682.x]. [PMID: 16603035].
[292]
Shetti, C.N.; Reddy, Y.C.; Kandavel, T.; Kashyap, K.; Singisetti, S.; Hiremath, A.S.; Siddequehusen, M.U.; Raghunandanan, S. Clinical predictors of drug nonresponse in obsessive-compulsive disorder. J. Clin. Psychiatry, 2005, 66(12), 1517-1523. [http:// dx.doi.org/10.4088/JCP.v66n1204]. [PMID: 16401151].
[293]
Denys, D.; Burger, H.; van Megen, H.; de Geus, F.; Westenberg, H. A score for predicting response to pharmacotherapy in obsessive-compulsive disorder. Int. Clin. Psychopharmacol., 2003, 18(6), 315-322. [http://dx.doi.org/10.1097/00004850-200311000-00002]. [PMID: 14571151].
[294]
Rosario-Campos, M.C.; Leckman, J.F.; Mercadante, M.T.; Shavitt, R.G.; Prado, H.S.; Sada, P.; Zamignani, D.; Miguel, E.C. Adults with early-onset obsessive-compulsive disorder. Am. J. Psychiatry, 2001, 158(11), 1899-1903. [http://dx.doi.org/10.1176/appi.ajp.158. 11.1899]. [PMID: 11691698].
[295]
Moritz, S.; Fricke, S.; Jacobsen, D.; Kloss, M.; Wein, C.; Rufer, M.; Katenkamp, B.; Farhumand, R.; Hand, I. Positive schizotypal symptoms predict treatment outcome in obsessive-compulsive disorder. Behav. Res. Ther., 2004, 42(2), 217-227. [http://dx.doi.org/ 10.1016/S0005-7967(03)00120-7]. [PMID: 14975782].
[296]
Overbeek, T.; Schruers, K.; Vermetten, E.; Griez, E. Comorbidity of obsessive-compulsive disorder and depression: prevalence, symptom severity, and treatment effect. J. Clin. Psychiatry, 2002, 63(12), 1106-1112. [http://dx.doi.org/10.4088/JCP.v63n1204]. [PMID: 12523869].
[297]
Brakoulias, V.; Starcevic, V.; Belloch, A.; Dell’Osso, L.; Ferrão, Y.A.; Fontenelle, L.F.; Lochner, C.; Marazziti, D.; Martin, A.; Matsunaga, H.; Miguel, E.C.; Reddy, Y.C.; do Rosário, M.C.; Shavitt, R.G.; Sundar, A.S.; Stein, D.J.; Viswasam, K. International prescribing practices in obsessive-compulsive disorder (OCD). Hum. Psychopharmacol., 2016, 31(4), 319-324. [http://dx.doi.org/10. 1002/hup.2541]. [PMID: 27271200].
[298]
Stewart, S.E.; Jenike, E.A.; Hezel, D.M.; Stack, D.E.; Dodman, N.H.; Shuster, L.; Jenike, M.A. A single-blinded case-control study of memantine in severe obsessive-compulsive disorder. J. Clin. Psychopharmacol., 2010, 30(1), 34-39. [http://dx.doi.org/10.1097/ JCP.0b013e3181c856de]. [PMID: 20075645].
[299]
Rodriguez, C.I.; Kegeles, L.S.; Levinson, A.; Feng, T.; Marcus, S.M.; Vermes, D.; Flood, P.; Simpson, H.B. Randomized controlled crossover trial of ketamine in obsessive-compulsive disorder: proof-of-concept. Neuropsychopharmacology, 2013, 38(12), 2475-2483. [http://dx.doi.org/10.1038/npp.2013.150]. [PMID: 23783065].
[300]
Hicks, J.K.; Swen, J.J.; Thorn, C.F.; Sangkuhl, K.; Kharasch, E.D.; Ellingrod, V.L.; Skaar, T.C.; Müller, D.J.; Gaedigk, A.; Stingl, J.C. Clinical Pharmacogenetics Implementation Consortium guideline for CYP2D6 and CYP2C19 genotypes and dosing of tricyclic antidepressants. Clin. Pharmacol. Ther., 2013, 93(5), 402-408. [http:// dx.doi.org/10.1038/clpt.2013.2]. [PMID: 23486447].
[301]
Müller, D.J.; Brandl, E.J.; Hwang, R.; Tiwari, A.K.; Sturgess, J.E.; Zai, C.C.; Lieberman, J.A.; Kennedy, J.L.; Richter, M.A. The AmpliChip® CYP450 test and response to treatment in schizophrenia and obsessive compulsive disorder: a pilot study and focus on cases with abnormal CYP2D6 drug metabolism. Genet. Test. Mol. Biomarkers, 2012, 16(8), 897-903. [http://dx.doi.org/10.1089/gtmb. 2011.0327]. [PMID: 22775532].
[302]
Brandl, E.J.; Tiwari, A.K.; Zhou, X.; Deluce, J.; Kennedy, J.L.; Müller, D.J.; Richter, M.A. Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder. Pharmacogenomics J., 2014, 14(2), 176-181. [http:// dx.doi.org/10.1038/tpj.2013.12]. [PMID: 23545896].
[303]
Zai, G.; Brandl, E.J.; Müller, D.J.; Richter, M.A.; Kennedy, J.L. Pharmacogenetics of antidepressant treatment in obsessive-compulsive disorder: an update and implications for clinicians. Pharmacogenomics, 2014, 15(8), 1147-1157. [http://dx.doi.org/ 10.2217/pgs.14.83]. [PMID: 25084207].
[304]
Ramamoorthy, S.; Bauman, A.L.; Moore, K.R.; Han, H.; Yang-Feng, T.; Chang, A.S.; Ganapathy, V.; Blakely, R.D. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc. Natl. Acad. Sci. USA, 1993, 90(6), 2542-2546. [http://dx.doi.org/10. 1073/pnas.90.6.2542]. [PMID: 7681602].
[305]
Heils, A.; Teufel, A.; Petri, S.; Stöber, G.; Riederer, P.; Bengel, D.; Lesch, K.P. Allelic variation of human serotonin transporter gene expression. J. Neurochem., 1996, 66(6), 2621-2624. [http://dx. doi.org/10.1046/j.1471-4159.1996.66062621.x]. [PMID: 8632190].
[306]
Bloch, M.H.; Landeros-Weisenberger, A.; Sen, S.; Dombrowski, P.; Kelmendi, B.; Coric, V.; Pittenger, C.; Leckman, J.F. Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am. J. Med. Genet. B. Neuropsychiatr. Genet., 2008, 147B(6), 850-858. [http://dx.doi.org/ 10.1002/ajmg.b.30699]. [PMID: 18186076].
[307]
Zitterl, W.; Stompe, T.; Aigner, M.; Zitterl-Eglseer, K.; Ritter, K.; Zettinig, G.; Hornik, K.; Asenbaum, S.; Pirker, W.; Thau, K. Diencephalic serotonin transporter availability predicts both transporter occupancy and treatment response to sertraline in obsessive-compulsive checkers. Biol. Psychiatry, 2009, 66(12), 1115-1122. [http://dx.doi.org/10.1016/j.biopsych.2009.07.009]. [PMID: 19717141].
[308]
Corregiari, F.M.; Bernik, M.; Cordeiro, Q.; Vallada, H. Endophenotypes and serotonergic polymorphisms associated with treatment response in obsessive-compulsive disorder. Clinics (São Paulo), 2012, 67(4), 335-340. [http://dx.doi.org/10.6061/clinics/2012(04)06]. [PMID: 22522758].
[309]
Vulink, N.C.; Westenberg, H.G.; van Nieuwerburgh, F.; Deforce, D.; Fluitman, S.B.; Meinardi, J.S.; Denys, D. Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder. Int. J. Psychiatry Clin. Pract., 2012, 16(4), 277-283. [http://dx.doi.org/10.3109/ 13651501.2011.653375]. [PMID: 22414277].
[310]
Kariuki-Nyuthe, C.; Gomez-Mancilla, B.; Stein, D.J. Obsessive compulsive disorder and the glutamatergic system. Curr. Opin. Psychiatry, 2014, 27(1), 32-37. [http://dx.doi.org/10.1097/YCO. 0000000000000017]. [PMID: 24270485].
[311]
Milad, M.R.; Rauch, S.L. Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways. Trends Cogn. Sci. (Regul. Ed.), 2012, 16(1), 43-51. [http://dx.doi.org/10.1016/j.tics.2011.11. 003] [PMID: 22138231].
[312]
Wendland, J.R.; Moya, P.R.; Timpano, K.R.; Anavitarte, A.P.; Kruse, M.R.; Wheaton, M.G.; Ren-Patterson, R.F.; Murphy, D.L. A haplotype containing quantitative trait loci for SLC1A1 gene expression and its association with obsessive-compulsive disorder. Arch. Gen. Psychiatry, 2009, 66(4), 408-416. [http://dx.doi.org/10. 1001/archgenpsychiatry.2009.6]. [PMID: 19349310].
[313]
Rosenberg, D.R.; Keshavan, M.S.A.E.A.E. Bennett Research Award. Toward a neurodevelopmental model of of obsessive--compulsive disorder. Biol. Psychiatry, 1998, 43(9), 623-640. [http:// dx.doi.org/10.1016/S0006-3223(97)00443-5]. [PMID: 9582996].
[314]
Huyser, C.; Veltman, D.J.; de Haan, E.; Boer, F. Paediatric obsessive-compulsive disorder, a neurodevelopmental disorder? Evidence from neuroimaging. Neurosci. Biobehav. Rev., 2009, 33(6), 818-830. [http://dx.doi.org/10.1016/j.neubiorev.2009.01.003]. [PMID: 19428494].
[315]
Gassó, P.; Ortiz, A.E.; Mas, S.; Morer, A.; Calvo, A.; Bargalló, N.; Lafuente, A.; Lázaro, L. Association between genetic variants related to glutamatergic, dopaminergic and neurodevelopment pathways and white matter microstructure in child and adolescent patients with obsessive-compulsive disorder. J. Affect. Disord., 2015, 186, 284-292. [http://dx.doi.org/10.1016/j.jad.2015.07.035]. [PMID: 26254621].
[316]
Cappi, C.; Brentani, H.; Lima, L.; Sanders, S.J.; Zai, G.; Diniz, B.J.; Reis, V.N.; Hounie, A.G.; Conceição do Rosário, M.; Mariani, D.; Requena, G.L.; Puga, R.; Souza-Duran, F.L.; Shavitt, R.G.; Pauls, D.L.; Miguel, E.C.; Fernandez, T.V. Whole-exome sequencing in obsessive-compulsive disorder identifies rare mutations in immunological and neurodevelopmental pathways. Transl. Psychiatry, 2016, 6e764 [http://dx.doi.org/10.1038/tp.2016.30]. [PMID: 27023170].
[317]
Melo-Felippe, F.B.; de Salles Andrade, J.B.; Giori, I.G.; Vieira-Fonseca, T.; Fontenelle, L.F.; Kohlrausch, F.B. Catechol-O-methyltransferase gene polymorphisms in specific obsessive-compulsive disorder patients’ subgroups. J. Mol. Neurosci., 2016, 58(1), 129-136. [http://dx.doi.org/10.1007/s12031-015-0697-0]. [PMID: 26687156].
[318]
Qin, H.; Samuels, J.F.; Wang, Y.; Zhu, Y.; Grados, M.A.; Riddle, M.A.; Greenberg, B.D.; Knowles, J.A.; Fyer, A.J.; McCracken, J.T.; Murphy, D.L.; Rasmussen, S.A.; Cullen, B.A.; Piacentini, J.; Geller, D.; Stewart, S.E.; Pauls, D.; Bienvenu, O.J.; Goes, F.S.; Maher, B.; Pulver, A.E.; Valle, D.; Lange, C.; Mattheisen, M.; McLaughlin, N.C.; Liang, K.Y.; Nurmi, E.L.; Askland, K.D.; Nestadt, G.; Shugart, Y.Y. Whole-genome association analysis of treatment response in obsessive-compulsive disorder. Mol. Psychiatry, 2016, 21(2), 270-276. [http://dx.doi.org/10.1038/mp.2015. 32]. [PMID: 25824302].
[319]
Etheridge, L.A.; Crawford, T.Q.; Zhang, S.; Roelink, H. Evidence for a role of vertebrate Disp1 in long-range Shh signaling. Development, 2010, 137(1), 133-140. [http://dx.doi.org/10.1242/dev. 043547]. [PMID: 20023168].
[320]
Lister, J.F. Pharmacogenomics: A focus on antidepressants and atypical antipsychotics. Ment Health Clin, 2016, 6(1), 48-53. [http://dx.doi.org/10.9740/mhc.2016.01.048]. [PMID: 29955447].
[321]
Fagerness, J.; Fonseca, E.; Hess, G.P.; Scott, R.; Gardner, K.R.; Koffler, M.; Fava, M.; Perlis, R.; Brennan, F.X.; Lombard, J. Pharmacogenetic-guided psychiatric intervention associated with increased adherence and cost savings. Am. J. Manag. Care, 2014, 20(5), e146-e156. [PMID: 25326929].
[322]
Singh, A.B. Improved antidepressant remission in major depression via a pharmacokinetic pathway polygene pharmacogenetic report. Clin. Psychopharmacol. Neurosci., 2015, 13(2), 150-156. [http://dx.doi.org/10.9758/cpn.2015.13.2.150]. [PMID: 26243841].
[323]
Russell, E.J.; Fawcett, J.M.; Mazmanian, D. Risk of obsessive-compulsive disorder in pregnant and postpartum women: a meta-analysis. J. Clin. Psychiatry, 2013, 74(4), 377-385. [http://dx.doi. org/10.4088/JCP.12r07917]. [PMID: 23656845].
[324]
Labad, J.; Menchón, J.M.; Alonso, P.; Segalàs, C.; Jiménez, S.; Vallejo, J. Female reproductive cycle and obsessive-compulsive disorder. J. Clin. Psychiatry, 2005, 66(4), 428-435. [http://dx.doi. org/10.4088/JCP.v66n0404]. [PMID: 15816784].
[325]
Uguz, F.; Gezginc, K.; Zeytinci, I.E.; Karatayli, S.; Askin, R.; Guler, O.; Kir, S.F.; Emul, H.M.; Ozbulut, O.; Gecici, O. Obsessive-compulsive disorder in pregnant women during the third trimester of pregnancy. Compr. Psychiatry, 2007, 48(5), 441-445. [http://dx.doi.org/10.1016/j.comppsych.2007.05.001]. [PMID: 17707252].
[326]
Forray, A.; Focseneanu, M.; Pittman, B.; McDougle, C.J.; Epperson, C.N. Onset and exacerbation of obsessive-compulsive disorder in pregnancy and the postpartum period. J. Clin. Psychiatry, 2010, 71(8), 1061-1068. [http://dx.doi.org/10.4088/JCP.09m05381blu]. [PMID: 20492843].
[327]
Loomans, E.M.; van der Stelt, O.; van Eijsden, M.; Gemke, R.J.; Vrijkotte, T.; den Bergh, B.R. Antenatal maternal anxiety is associated with problem behaviour at age five. Early Hum. Dev., 2011, 87(8), 565-570. [http://dx.doi.org/10.1016/j.earlhumdev.2011.04. 014]. [PMID: 21576004].
[328]
Sanchez, S.E.; Puente, G.C.; Atencio, G.; Qiu, C.; Yanez, D.; Gelaye, B.; Williams, M.A. Risk of spontaneous preterm birth in relation to maternal depressive, anxiety, and stress symptoms. J. Reprod. Med., 2013, 58(1-2), 25-33. [PMID: 23447915].
[329]
Van Batenburg-Eddes, T.; Brion, M.J.; Henrichs, J.; Jaddoe, V.W.; Hofman, A.; Verhulst, F.C.; Lawlor, D.A.; Davey Smith, G.; Tiemeier, H. Parental depressive and anxiety symptoms during pregnancy and attention problems in children: a cross-cohort consistency study. J. Child Psychol. Psychiatry, 2013, 54(5), 591-600. [http://dx.doi.org/10.1111/jcpp.12023]. [PMID: 23215861].
[330]
Leis, J.A.; Heron, J.; Stuart, E.A.; Mendelson, T. Associations between maternal mental health and child emotional and behavioral problems: does prenatal mental health matter? J. Abnorm. Child Psychol., 2014, 42(1), 161-171. [http://dx.doi.org/10.1007/s10802-013-9766-4]. [PMID: 23748337].
[331]
Ding, X.X.; Wu, Y.L.; Xu, S.J.; Zhu, R.P.; Jia, X.M.; Zhang, S.F.; Huang, K.; Zhu, P.; Hao, J.H.; Tao, F.B. Maternal anxiety during pregnancy and adverse birth outcomes: a systematic review and meta-analysis of prospective cohort studies. J. Affect. Disord., 2014, 159, 103-110. [http://dx.doi.org/10.1016/j.jad.2014.02.027]. [PMID: 24679397].
[332]
Uguz, F.; Onder Sonmez, E.; Sahingoz, M.; Gokmen, Z.; Basaran, M.; Gezginc, K.; Sonmez, G.; Kaya, N.; Yilmaz, E.; Erdem, S.S.; Dulger, H.H.; Cicekler, H.; Tasyurek, E. Neuroinflammation in the fetus exposed to maternal obsessive-compulsive disorder during pregnancy: a comparative study on cord blood tumor necrosis factor-alpha levels. Compr. Psychiatry, 2014, 55(4), 861-865. [http:// dx.doi.org/10.1016/j.comppsych.2013.12.018]. [PMID: 24480417].
[333]
Byatt, N.; Deligiannidis, K.M.; Freeman, M.P. Antidepressant use in pregnancy: a critical review focused on risks and controversies. Acta Psychiatr. Scand., 2013, 127(2), 94-114. [http://dx.doi.org/10. 1111/acps.12042]. [PMID: 23240634].
[334]
Yonkers, K.A.; Wisner, K.L.; Stewart, D.E.; Oberlander, T.F.; Dell, D.L.; Stotland, N.; Ramin, S.; Chaudron, L.; Lockwood, C. The management of depression during pregnancy: a report from the American Psychiatric Association and the American College of Obstetricians and Gynecologists. Gen. Hosp. Psychiatry, 2009, 31(5), 403-413. [http://dx.doi.org/10.1016/j.genhosppsych.2009.04. 003]. [PMID: 19703633].
[335]
Uguz, F. Pharmacotherapy of obsessive-compulsive disorder during pregnancy: a clinical approach. Rev. Bras. Psiquiatr., 2015, 37(4), 334-342. [http://dx.doi.org/10.1590/1516-4446-2015-1673]. [PMID: 26692431].
[336]
Kellner, M. Drug treatment of obsessive-compulsive disorder. Dialogues Clin. Neurosci., 2010, 12(2), 187-197. [PMID: 20623923].
[337]
Ellfolk, M.; Malm, H. Risks associated with in utero and lactation exposure to selective serotonin reuptake inhibitors (SSRIs). Reprod. Toxicol., 2010, 30(2), 249-260. [http://dx.doi.org/10.1016/ j.reprotox.2010.04.015]. [PMID: 20447455].
[338]
Gentile, S. Drug treatment for mood disorders in pregnancy. Curr. Opin. Psychiatry, 2011, 24(1), 34-40. [http://dx.doi.org/10.1097/ YCO.0b013e3283413451]. [PMID: 21088587].
[339]
Malm, H.; Artama, M.; Gissler, M.; Ritvanen, A. Selective serotonin reuptake inhibitors and risk for major congenital anomalies. Obstet. Gynecol., 2011, 118(1), 111-120. [http://dx.doi.org/10. 1097/AOG.0b013e318220edcc]. [PMID: 21646927].
[340]
Lorenzo, L.; Byers, B.; Einarson, A. Antidepressant use in pregnancy. Expert Opin. Drug Saf., 2011, 10(6), 883-889. [http://dx. doi.org/10.1517/14740338.2011.583917]. [PMID: 21545242].
[341]
Myles, N.; Newall, H.; Ward, H.; Large, M. Systematic meta-analysis of individual selective serotonin reuptake inhibitor medications and congenital malformations. Aust. N. Z. J. Psychiatry, 2013, 47(11), 1002-1012. [http://dx.doi.org/10.1177/0004867413492219]. [PMID: 23761574].
[342]
Grigoriadis, S. VonderPorten, E.H.; Mamisashvili, L.; Roerecke, M.; Rehm, J.; Dennis, C.L.; Koren, G.; Steiner, M.; Mousmanis, P.; Cheung, A.; Ross, L.E. Antidepressant exposure during pregnancy and congenital malformations: is there an association? A systematic review and meta-analysis of the best evidence. J. Clin. Psychiatry, 2013, 74(4), e293-e308. [http://dx.doi.org/10.4088/JCP.12r07966]. [PMID: 23656855].
[343]
Klieger-Grossmann, C.; Weitzner, B.; Panchaud, A.; Pistelli, A.; Einarson, T.; Koren, G.; Einarson, A. Pregnancy outcomes following use of escitalopram: a prospective comparative cohort study. J. Clin. Pharmacol., 2012, 52(5), 766-770. [http://dx.doi.org/10.1177/ 0091270011405524]. [PMID: 22075232].
[344]
Bellantuono, C.; Bozzi, F.; Orsolini, L.; Catena-Dell’Osso, M. The safety of escitalopram during pregnancy and breastfeeding: a comprehensive review. Hum. Psychopharmacol., 2012, 27(6), 534-539. [http://dx.doi.org/10.1002/hup.2265]. [PMID: 23044635].
[345]
Alwan, S.; Reefhuis, J.; Rasmussen, S.A.; Friedman, J.M. Patterns of antidepressant medication use among pregnant women in a United States population. J. Clin. Pharmacol., 2011, 51(2), 264-270. [http://dx.doi.org/10.1177/0091270010373928]. [PMID: 20663997].
[346]
Andrade, S.E.; Raebel, M.A.; Brown, J.; Lane, K.; Livingston, J.; Boudreau, D.; Rolnick, S.J.; Roblin, D.; Smith, D.H.; Willy, M.E.; Staffa, J.A.; Platt, R. Use of antidepressant medications during pregnancy: a multisite study. Am. J. Obstet. Gynecol., 2008, 198(2), 194.e1-194.e5. [http://dx.doi.org/10.1016/j.ajog.2007.07. 036]. [PMID: 17905176].
[347]
Yonkers, K.A.; Blackwell, K.A.; Glover, J.; Forray, A. Antidepressant use in pregnant and postpartum women. Annu. Rev. Clin. Psychol., 2014, 10, 369-392. [http://dx.doi.org/10.1146/annurev-clinpsy-032813-153626]. [PMID: 24313569].
[348]
Gentile, S. Tricyclic antidepressants in pregnancy and puerperium. Expert Opin. Drug Saf., 2014, 13(2), 207-225. [http://dx.doi.org/10. 1517/14740338.2014.869582]. [PMID: 24383525].
[349]
Källén, B.A.; Otterblad Olausson, P. Maternal drug use in early pregnancy and infant cardiovascular defect. Reprod. Toxicol., 2003, 17(3), 255-261. [http://dx.doi.org/10.1016/S0890-6238(03)00012-1]. [PMID: 12759093].
[350]
Källén, B.; Otterblad Olausson, P. Antidepressant drugs during pregnancy and infant congenital heart defect. Reprod. Toxicol., 2006, 21(3), 221-222. [http://dx.doi.org/10.1016/j.reprotox.2005. 11.006]. [PMID: 16406480].
[351]
Udechuku, A.; Nguyen, T.; Hill, R.; Szego, K. Antidepressants in pregnancy: a systematic review. Aust. N. Z. J. Psychiatry, 2010, 44(11), 978-996. [PMID: 21034181].
[352]
Seibell, P.J.; Hollander, E. Management of obsessive-compulsive disorder. F1000Prime Rep., 2014, 6, 68. [http://dx.doi.org/10. 12703/P6-68]. [PMID: 25165567].
[353]
Suri, R.; Altshuler, L.; Hellemann, G.; Burt, V.K.; Aquino, A.; Mintz, J. Effects of antenatal depression and antidepressant treatment on gestational age at birth and risk of preterm birth. Am. J. Psychiatry, 2007, 164(8), 1206-1213. [http://dx.doi.org/10.1176/ appi.ajp.2007.06071172]. [PMID: 17671283].
[354]
Andrade, C. Augmenting selective serotonin reuptake inhibitors with clomipramine in obsessive-compulsive disorder: benefits and risks. J. Clin. Psychiatry, 2013, 74(12), e1128-e1133. [http://dx. doi.org/10.4088/JCP.13f08883]. [PMID: 24434100].
[355]
Diniz, J.B.; Shavitt, R.G.; Pereira, C.A.; Hounie, A.G.; Pimentel, I.; Koran, L.M.; Dainesi, S.M.; Miguel, E.C. Quetiapine versus clomipramine in the augmentation of selective serotonin reuptake inhibitors for the treatment of obsessive-compulsive disorder: a randomized, open-label trial. J. Psychopharmacol. (Oxford), 2010, 24(3), 297-307. [http://dx.doi.org/10.1177/0269881108099423]. [PMID: 19164490].
[356]
Skapinakis, P.; Papatheodorou, T.; Mavreas, V. Antipsychotic augmentation of serotonergic antidepressants in treatment-resistant obsessive-compulsive disorder: a meta-analysis of the randomized controlled trials. Eur. Neuropsychopharmacol., 2007, 17(2), 79-93. [http://dx.doi.org/10.1016/j.euroneuro.2006.07.002]. [PMID: 16904298].
[357]
Bloch, M.H.; Peterson, B.S.; Scahill, L.; Otka, J.; Katsovich, L.; Zhang, H.; Leckman, J.F. Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome. Arch. Pediatr. Adolesc. Med., 2006, 160(1), 65-69. [http://dx. doi.org/10.1001/archpedi.160.1.65]. [PMID: 16389213].
[358]
National Institute for Health and Care Excellence. 2013.https:// www.nice.org.uk/guidance/cg31
[359]
Poppe, C.; Müller, S.T.; Greil, W.; Walder, A.; Grohmann, R.; Stübner, S. Pharmacotherapy for obsessive compulsive disorder in clinical practice - Data of 842 inpatients from the International AMSP Project between 1994 and 2012. J. Affect. Disord., 2016, 200, 89-96. [http://dx.doi.org/10.1016/j.jad.2016.04.035]. [PMID: 27130958].
[360]
Bandelow, B.; Sher, L.; Bunevicius, R.; Hollander, E.; Kasper, S.; Zohar, J.; Möller, H.J. Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care. Int. J. Psychiatry Clin. Pract., 2012, 16(2), 77-84. [http://dx.doi.org/10.3109/13651501. 2012.667114]. [PMID: 22540422].
[361]
Koran, L.M.; Simpson, H.B. Guideline Watch (March 2013): Practice Guideline for the Treatment of patients with Obsessive-Compulsive Disorder; American Psychiatric Association: Arlington, VA, 2013.
[362]
Moher, D.; Liberati, A.; Tetzlaff, J.; Altman, D.G. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int. J. Surg., 2010, 8(5), 336-341. [http://dx.doi.org/10. 1016/j.ijsu.2010.02.007]. [PMID: 20171303].


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VOLUME: 17
ISSUE: 8
Year: 2019
Page: [710 - 736]
Pages: 27
DOI: 10.2174/1570159X16666180813155017
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