Introduction: Alzheimer's disease is known to be a chronic disease, with an estimated prevalence
of about 10-30%, considering the population over 60 years of age. Most patients with this disorder
(> 95%) present the sporadic form, being characterized by a late onset (80-90 years of age), and it is the
consequence of the failure to clear the amyloid-β (Aβ) peptide from the interstices of the brain. Significant
numbers of genetic risk factors for the sporadic disease have been researched. Some existing drugs
for Alzheimer's disease provide symptomatic benefit for up to 12 months, but there are no approved disease-
modifying therapies. In this line, a complementary strategy based on repositioning drugs which are
approved for the treatment of other disorders could be interesting. It is noteworthy the fact that some
clinical trials indicate that several classes of drugs own potent and beneficial effects on the Alzheimer's
disease treatment. In this present work, we present the details and evaluation of these alternative treatments.
It has highlighted several compounds with relevant evidence for this purpose, which deserves
further investigation to clarify optimal treatment conditions in the clinical trials of patients with Alzheimer's
Keywords: Alzheimer’s disease, neurodegeneration, drug repositioning, tau protein, amyloid-β peptide, pharmacophores.
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