Review Article

Phytoconstituents and their Possible Mechanistic Profile for Alzheimer’s Disease – A Literature Review

Author(s): Duraiswamy Basavan, Nehru S.S. Chalichem* and Mohan K.S. Kumar

Volume 20, Issue 3, 2019

Page: [263 - 291] Pages: 29

DOI: 10.2174/1389450119666180813095637

Price: $65

Abstract

Memory is an associated part of life without which livelihood of a human being becomes miserable. As the global aged population is increasing tremendously, time has come to concentrate on tail end life stage diseases. Alzheimer’s disease (AD) is one of such diseases whose origin is enigmatic, having an impact on later stage of life drastically due to irreparable damage of cognition, characterised by the presence of neurotoxic amyloid-beta (Aβ) plaques and hyper phosphorylated Tau protein as fibrillary tangles. Existing therapeutic regimen mainly focuses on symptomatic relief by targeting neurotransmitters that are secondary to AD pathology. Plant derived licensed drugs, Galantamine and Huperzine-A were studied extensively due to their AChE inhibitory action for mild to moderate cases of AD. Although many studies have proved the efficacy of AChEIs as a preferable symptom reliever, they cannot offer long term protection. The future generation drugs of AD is expected to alter various factors that underlie the disease course with a symptomatic benefit promise. As AD involves complex pathology, it is essential to consider several molecular divergent factors apart from the events that result in the production of toxic plaques and neurofibrillary tangles. Even though several herbals have shown neuroprotective actions, we have mentioned about the phytoconstituents that have been tested experimentally against different Alzheimer’s pathology models. These phytoconstituents need to be considered by the researchers for further drug development process to make them viable clinically, which is currently a lacuna.

Keywords: Alzheimer's disease, amyloid beta, phytoconstituents, traditional medicine and neurogenesis, AChEIs, Galantamine and Huperzine-A.

Graphical Abstract
[1]
Wright B, Davison P. Guest editorial: Mechanisms of development and aging. Mech Ageing Dev 1980; 12(3): 213-9.
[2]
Baquer N, Hothersall J, McLean P, Greenbaum A. Effect of aging on soluble and membrane bound enzymes in rat brain. Neurochem Int 1990; 16(3): 369-75.
[3]
Mattson MP. Impairment of membrane transport and signal transduction systems by amyloidogenic proteins. Methods Enzymol 1999; 309: 733-46.
[4]
Squier TC. Oxidative stress and protein aggregation during biological aging. Exp Gerontol 2001; 36(9): 1539-50.
[5]
Basavan D, Sai Suresh Chalichem N, Thaggikuppe Krishnamurthy P, Kumar Chintamaneni P, Vanitha B. Possible targets of herbals for type 3 diabetes: A review. Curr Tradit Med 2016; 2(3): 148-85.
[6]
Davis J, Couch R. Strategizing the development of Alzheimer’s therapeutics. Adv Alzheimer Dis 2014; 3(03): 107.
[7]
Sadigh-Eteghad S, Sabermarouf B, Majdi A, Talebi M, Farhoudi M, Mahmoudi J. Amyloid-beta: A crucial factor in Alzheimer’s disease. Med Princ Pract 2015; 24(1): 1-10.
[8]
Hardy JA, Higgins GA. Alzheimer’s disease: The amyloid cascade hypothesis. Science 1992; 256(5054): 184.
[9]
Erten-Lyons D, Woltjer R, Dodge H, et al. Factors associated with resistance to dementia despite high Alzheimer disease pathology. Neurol 2009; 72(4): 354-60.
[10]
Sloane J, Pietropaolo M, Rosene D, et al. Lack of correlation between plaque burden and cognition in the aged monkey. Acta Neuropathol 1997; 94(5): 471-8.
[11]
Sengupta U, Nilson AN, Kayed R. The role of amyloid-β oligomers in toxicity, propagation, and immunotherapy. EBioMedicine 2016; 6: 42-9.
[12]
Roe CM, Mintun MA, D’Angelo G, Xiong C, Grant EA, Morris JC. Alzheimer disease and cognitive reserve: variation of education effect with carbon 11–labeled Pittsburgh Compound B uptake. Arch Neurol 2008; 65(11): 1467-71.
[13]
Lesné S, Kotilinek L, Ashe KH. Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory function. Neurosci 2008; 151(3): 745-9.
[14]
Gandy S, Simon AJ, Steele JW, et al. Days to criterion as an indicator of toxicity associated with human Alzheimer amyloid‐β oligomers. Ann Neurol 2010; 68(2): 220-30.
[15]
Carrotta R, Di Carlo M, Manno M, et al. Toxicity of recombinant β-amyloid prefibrillar oligomers on the morphogenesis of the sea urchin Paracentrotus lividus. FASEB J 2006; 20(11): 1916-7.
[16]
Paranjape GS, Gouwens LK, Osborn DC, Nichols MR. Isolated amyloid-β (1–42) protofibrils, but not isolated fibrils, are robust stimulators of microglia. ACS Chem Neurosci 2012; 3(4): 302-11.
[17]
McLean CA, Cherny RA, Fraser FW, et al. Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer’s disease. Ann Neurol 1999; 46(6): 860-6.
[18]
Näslund J, Haroutunian V, Mohs R, et al. Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline. JAMA 2000; 283(12): 1571-7.
[19]
Wang J, Dickson DW, Trojanowski JQ, Lee VM-Y. The levels of soluble versus insoluble brain Aβ distinguish Alzheimer’s disease from normal and pathologic aging. Exp Neurol 1999; 158(2): 328-37.
[20]
Blass JP, Zemcov A. Alzheimer’s disease. Mol Chem Neuropathol 1984; 2(2): 103-14.
[21]
Gibson GE, Sheu K-FR, Blass JP, et al. Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer’s disease. Arch Neurol 1988; 45(8): 836-40.
[22]
Castellani R, Hirai K, Aliev G, et al. Role of mitochondrial dysfunction in Alzheimer’s disease. J Neurosci Res 2002; 70(3): 357-60.
[23]
Trifunovic A, Wredenberg A, Falkenberg M, et al. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 2004; 429(6990): 417-23.
[24]
Ross JM, Stewart JB, Hagstrom E, et al. Germline mitochondrial DNA mutations aggravate ageing and can impair brain development. Nature 2013; 501(7467): 412-5.
[25]
Parker W. Editor Sporadic neurologic disease and the electron transport chain: A hypothesis. Proceedings of the 1989 Scientfic Meeting of the American Society for Neurological Investigation: New Developments in Neuromuscular Disease edited by Pascuzzi RM Bloomington, Indiana: Indiana University Printing Services; 1990
[26]
Linnane A, Ozawa T, Marzuki S, Tanaka M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 1989; 333(8639): 642-5.
[27]
Wallace DC. Mitochondrial genetics: A paradigm for aging and degenerative diseases. Science 1992; 256(5057): 628-32.
[28]
Lin MT, Simon DK, Ahn CH, Kim LM, Beal MF. High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer’s disease brain. Hum Mol Genet 2002; 11(2): 133-45.
[29]
Webster M-T, Pearce B, Bowen D, Francis P. The effects of perturbed energy metabolism on the processing of amyloid precursor protein in PC12 cells. J Neural Transm 1998; 105(8): 839-53.
[30]
Gabuzda D, Busciglio J, Chen LB, Matsudaira P, Yankner BA. Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. J Biol Chem 1994; 269(18): 13623-8.
[31]
Szabados T, Dul C, Majtényi K, Hargitai J, Pénzes Z, Urbanics R. A chronic Alzheimer’s model evoked by mitochondrial poison sodium azide for pharmacological investigations. Behav Brain Res 2004; 154(1): 31-40.
[32]
Smith MA, Rudnicka‐Nawrot M, Richey PL, et al. Carbonyl‐related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer’s disease. J Neurochem 1995; 64(6): 2660-6.
[33]
Markesbery WR. The role of oxidative stress in Alzheimer disease. Arch Neurol 1999; 56(12): 1449-52.
[34]
Blass JP, Baker AC, Ko L-W, Black RS. Induction of Alzheimer antigens by an uncoupler of oxidative phosphorylation. Arch Neurol 1990; 47(8): 864-9.
[35]
Swerdlow RH, Khan SM. The Alzheimer’s disease mitochondrial cascade hypothesis: An update. Exp Neurol 2009; 218(2): 308-15.
[36]
Davies P, Maloney A. Selective loss of central cholinergic neurons in Alzheimer’s disease. Lancet 1976; 308(8000): 1403.
[37]
Craig LA, Hong NS, McDonald RJ. Revisiting the cholinergic hypothesis in the development of Alzheimer’s disease. Neurosci Biobehav Rev 2011; 35(6): 1397-409.
[38]
Doody R, Dunn J, Clark C, et al. Chronic donepezil treatment is associated with slowed cognitive decline in Alzheimer’s disease. Dement Geriatr Cogn Disord 2001; 12(4): 295-300.
[39]
Courtney C, Farrell D, Gray R, et al. Long-term donepezil treatment in 565 patients with Alzheimer’s disease (AD2000): randomised double-blind trial. Lancet (London, England) 2004; 363(9427): 2105-15.
[40]
McDonald RJ. Multiple combinations of co-factors produce variants of age-related cognitive decline: A theory. Can J Exp Psychol 2002; 56(3): 221.
[41]
McDonald RJ, Craig LA, Hong NS. The etiology of age-related dementia is more complicated than we think. Behav Brain Res 2010; 214(1): 3-11.
[42]
Howes M-JR, Houghton PJ. Acetylcholinesterase inhibitors of natural origin. Int J Biomed Pharm Sci 2009; 3(SI1): 67-86.
[43]
Park CH, Kim S-H, Choi W, et al. Novel anticholinesterase and antiamnesic activities of dehydroevodiamine, a constituent of Evodia rutaecarpa. Planta Med 1996; 62(05): 405-9.
[44]
Pereira DM, Ferreres F, Oliveira JM, et al. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine 2010; 17(8-9): 646-52.
[45]
Halldorsdottir E, Olafsdottir E. Alkaloids from the club moss Lycopodium annotinum L–acetylcholinesterase inhibitory activity in vitro. Planta Medica 2006. 72(11): P_106.
[46]
Hornick A, Schwaiger S, Rollinger JM, Vo NP, Prast H, Stuppner H. Extracts and constituents of Leontopodium alpinum enhance cholinergic transmission: Brain ACh increasing and memory improving properties. Biochem Pharmacol 2008; 76(2): 236-48.
[47]
Ono K, Hasegawa K, Yamada M, Naiki H. Nicotine breaks down preformed Alzheimer’s β-amyloid fibrils in vitro. Biol Psychiatry 2002; 52(9): 880-6.
[48]
Nordberg A, Hellström‐Lindahl E, Lee M, et al. Chronic nicotine treatment reduces β‐amyloidosis in the brain of a mouse model of Alzheimer’s disease (APPsw). J Neurochem 2002; 81(3): 655-8.
[49]
Majdi A, Kamari F, Vafaee MS, Sadigh-Eteghad S. Revisiting nicotine’s role in the ageing brain and cognitive impairment. Rev Neurosci 2017; 28(7): 767-81.
[50]
Dohi S, Terasaki M, Makino M. Acetylcholinesterase inhibitory activity and chemical composition of commercial essential oils. J Agric Food Chem 2009; 57(10): 4313-8.
[51]
Menichini F, Tundis R, Loizzo MR, et al. Acetylcholinesterase and butyrylcholinesterase inhibition of ethanolic extract and monoterpenes from Pimpinella anisoides V Brig.(Apiaceae). Fitoterapia 2009; 80(5): 297-300.
[52]
Kumar V, Mukherjee K, Pal B, Houghton P, Mukherjee P. Acetylcholinesterase inhibitor from Clitoria ternatea. Planta Med 2007; 73(09): 479.
[53]
Zhou W, Fukumoto S, Yokogoshi H. Components of lemon essential oil attenuate dementia induced by scopolamine. Nutr Neurosci 2009; 12(2): 57-64.
[54]
Khan MTH, Orhan I, Şenol F, et al. Cholinesterase inhibitory activities of some flavonoid derivatives and chosen xanthone and their molecular docking studies. Chem Biol Interact 2009; 181(3): 383-9.
[55]
Peron R, Vatanabe IP, Manzine PR, Camins A, Cominetti MR. Alpha-secretase ADAM10 regulation: Insights into Alzheimer’s disease treatment. Pharmaceuticals 2018; 11(1): 12.
[56]
Yan R. Physiological functions of the β-site amyloid precursor protein cleaving enzyme 1 and 2. Front Mol Neurosci 2017; 10: 97.
[57]
Jung HA, Lee EJ, Kim JS, et al. Cholinesterase and BACE1 inhibitory diterpenoids from Aralia cordata. Arch Pharm Res 2009; 32(10): 1399.
[58]
Ono K, Yoshiike Y, Takashima A, Hasegawa K, Naiki H, Yamada M. Vitamin A exhibits potent antiamyloidogenic and fibril-destabilizing effects in vitro. Exp Neurol 2004; 189(2): 380-92.
[59]
Defeudis FV. Bilobalide and neuroprotection. Pharmacol Res 2002; 46(6): 565-8.
[60]
Zhou L-J, Zhu X-Z. Reactive oxygen species-induced apoptosis in PC12 cells and protective effect of bilobalide. J Pharmacol Exp Ther 2000; 293(3): 982-8.
[61]
Shi C, Wu F, Xu J, Zou J. Bilobalide regulates soluble amyloid precursor protein release via phosphatidyl inositol 3 kinase-dependent pathway. Neurochem Int 2011; 59(1): 59-64.
[62]
Lee Y-B, Lee HJ, Won MH, et al. Soy isoflavones improve spatial delayed matching-to-place performance and reduce cholinergic neuron loss in elderly male rats. J Nutr 2004; 134(7): 1827-31.
[63]
Jung M, Park M. Acetylcholinesterase inhibition by flavonoids from Agrimonia pilosa. Molecul 2007; 12(9): 2130-9.
[64]
Cui Y-M, Ao M-Z, Li W, Yu L-J. Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice. Planta Med 2008; 74(04): 377-80.
[65]
Orhan I, Şenol F, Kartal M, et al. Cholinesterase inhibitory effects of the extracts and compounds of Maclura pomifera (Rafin.) Schneider. Food Chem Toxicol 2009; 47(8): 1747-51.
[66]
Shimmyo Y, Kihara T, Akaike A, Niidome T, Sugimoto H. Flavonols and flavones as BACE-1 inhibitors: structure–activity relationship in cell-free, cell-based and in silico studies reveal novel pharmacophore features. Biochim Biophys Acta 2008; 1780(5): 819-25.
[67]
Choi YH, Yon GH, Hong KS, et al. In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia. Planta Med 2008; 74(11): 1405-8.
[68]
Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the Indian solid gold The molecular targets and therapeutic uses of curcumin in health and disease. Springer 2007; pp. 1-75.
[69]
Narasingapa RB, Jargaval MR, Pullabhatla S, et al. Activation of α-secretase by curcumin-aminoacid conjugates. Biochem Biophys Res Commun 2012; 424(4): 691-6.
[70]
Mishra S, Palanivelu K. The effect of curcumin (turmeric) on Alzheimer’s disease: An overview. Ann Indian Acad Neurol 2008; 11(1): 13.
[71]
Wang J, Zhang Y, Du S. The protective effect of curcumin on Aß induced aberrant cell cycle reentry on primary cultured rat cortical neurons. Eur Rev Med Pharmacol Sci 2012; 16(4): 445-54.
[72]
Xiong Z, Hongmei Z, Lu S, Yu L. Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s Disease. Pharmacol Rep 2011; 63(5): 1101-8.
[73]
Caesar I, Jonson M, Nilsson KPR, Thor S, Hammarström P. Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila. PLoS One 2012; 7(2): e31424.
[74]
Park HR, Kim JY, Lee Y, et al. PMC-12, a traditional herbal medicine, enhances learning memory and hippocampal neurogenesis in mice. Neurosci Lett 2016; 617: 254-63.
[75]
Mori T, Koyama N, Tan J, et al. Combination therapy with octyl gallate and ferulic acid improves cognition and neurodegeneration in a transgenic mouse model of Alzheimer’s disease. J Biol Chem 2017; 292(27): 11310-25.
[76]
Lee HE, Kim DH, Park SJ, et al. Neuroprotective effect of sinapic acid in a mouse model of amyloid β 1–42 protein-induced Alzheimer’s disease. Pharmacol Biochem Behav 2012; 103(2): 260-6.
[77]
Limón ID, Mendieta L, Díaz A, et al. Neuroprotective effect of alpha-asarone on spatial memory and nitric oxide levels in rats injected with amyloid-β (25–35). Neurosci Lett 2009; 453(2): 98-103.
[78]
Mathew M, Sagar BC, Subramanian S. Identification of small molecule inhibitors against amyloid â (aâ) oligomerization and toxicity from nootropic ayurvedic herbal extracts. Int J Pharm Sci Res 2013; 4(12): 4685.
[79]
Liu J, Li C, Xing G, et al. Beta-asarone attenuates neuronal apoptosis induced by Beta amyloid in rat hippocampus. Yakugaku Zasshi 2010; 130(5): 737-46.
[80]
Liu S-j, Yang C, Zhang Y, et al. Neuroprotective effect of β-asarone against alzheimer’s disease: Regulation of synaptic plasticity by increased expression of sYP and glur1. Drug Des Devel Ther 2016; 10: 1461.
[81]
Huang D, Hu Z, Yu Z. Eleutheroside B or E enhances learning and memory in experimentally aged rats. Neural Regen Res 2013; 8(12): 1103.
[82]
Irie Y, Keung WM. Rhizoma acori graminei and its active principles protect PC-12 cells from the toxic effect of amyloid-β peptide. Brain Res 2003; 963(1): 282-9.
[83]
Du W-J, Guo J-J, Gao M-T, et al. Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity. Sci Rep 2015; 5.
[84]
Fujiwara H, Tabuchi M, Yamaguchi T, et al. A traditional medicinal herb Paeonia suffruticosa and its active constituent 1, 2, 3, 4, 6‐penta‐O‐galloyl‐β‐d‐glucopyranose have potent anti‐aggregation effects on Alzheimer’s amyloid β proteins in vitro and in vivo. J Neurochem 2009; 109(6): 1648-57.
[85]
Porzoor A, Alford B, Hügel HM, Grando D, Caine J, Macreadie I. Anti-amyloidogenic properties of some phenolic compounds. Biomolecules 2015; 5(2): 505-27.
[86]
Na CS, Hong SS, Choi Y-H, et al. Neuroprotective effects of constituents of Eragrostis ferruginea against Aβ-induced toxicity in PC12 cells. Arch Pharm Res 2010; 33(7): 999-1003.
[87]
Sul D, Kim H-S, Lee D, Joo SS, Hwang KW, Park S-Y. Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation. Life Sci 2009; 84(9): 257-62.
[88]
Zhang J-S, Zhou S-F, Wang Q, et al. Gastrodin suppresses BACE1 expression under oxidative stress condition via inhibition of the PKR/eIF2α pathway in Alzheimer’s disease. Neuroscience 2016; 325: 1-9.
[89]
Riviere C, Richard T, Vitrac X, Mérillon J-M, Valls J, Monti J-P. New polyphenols active on β-amyloid aggregation. Bioorg Med Chem Lett 2008; 18(2): 828-31.
[90]
Wang T, Fu F, Han B, Zhang L, Zhang X. Danshensu ameliorates the cognitive decline in streptozotocin-induced diabetic mice by attenuating advanced glycation end product-mediated neuroinflammation. J Neuroimmunol 2012; 245(1): 79-86.
[91]
Kim YS. Magnolol protects against trimethyltin-induced neuronal damage and glial activation in vitro and in vivo. Neurotoxicol 2016; 53: 173-85.
[92]
Kwak H-M, Jeon S-Y, Sohng B-H, et al. β-Secretase (BACE1) inhibitors from pomegranate (Punica granatum) husk. Arch Pharm Res 2005; 28(12): 1328-32.
[93]
Mori T, Rezai-Zadeh K, Koyama N, et al. Tannic acid is a natural β-secretase inhibitor that prevents cognitive impairment and mitigates Alzheimer-like pathology in transgenic mice. J Biol Chem 2012; 287(9): 6912-27.
[94]
Bieschke J, Russ J, Friedrich RP, et al. EGCG remodels mature α-synuclein and amyloid-β fibrils and reduces cellular toxicity. Proc Natl Acad Sci 2010; 107(17): 7710-5.
[95]
Rezai-Zadeh K, Shytle D, Sun N, et al. Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice. J Neurosci 2005; 25(38): 8807-14.
[96]
Ono K, Hirohata M, Yamada M. Ferulic acid destabilizes preformed β-amyloid fibrils in vitro. Biochem Biophys Res Commun 2005; 336(2): 444-9.
[97]
Hajipour S, Sarkaki A, Farbood Y, Eidi A, Mortazavi P, Valizadeh Z. Effect of gallic acid on dementia type of Alzheimer disease in rats: Electrophysiological and histological studies. Basic Clin Neurosci 2016; 7(2): 97.
[98]
Daccache A, Lion C, Sibille N, et al. Oleuropein and derivatives from olives as Tau aggregation inhibitors. Neurochem Int 2011; 58(6): 700-7.
[99]
Choi Y-h, Hong SS, Shin YS, Hwang BY, Park S-Y, Lee D. Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity. Arch Pharm Res 2010; 33(10): 1651-4.
[100]
Dilshara MG, Lee K-T, Kim HJ, et al. Anti-inflammatory mechanism of α-viniferin regulates lipopolysaccharide-induced release of proinflammatory mediators in BV2 microglial cells. Cell Immunol 2014; 290(1): 21-9.
[101]
Airoldi C, Sironi E, Dias C, et al. Natural compounds against Alzheimer’s disease: Molecular recognition of Aβ1–42 peptide by salvia sclareoides extract and its major component, rosmarinic acid, as investigated by NMR. Chem Asian J 2013; 8(3): 596-602.
[102]
Kuk EB, Jo AR, Oh SI, et al. Anti-Alzheimer’s disease activity of compounds from the root bark of Morus alba L. Arch Pharm Res 2017; 40(3): 338-49.
[103]
Porat Y, Abramowitz A, Gazit E. Inhibition of amyloid fibril formation by polyphenols: Structural similarity and aromatic interactions as a common inhibition mechanism. Chem Biol Drug Des 2006; 67(1): 27-37.
[104]
Chen J, Deng X, Liu N, et al. Quercetin attenuates tau hyperphosphorylation and improves cognitive disorder via suppression of ER stress in a manner dependent on AMPK pathway. J Funct Foods 2016; 22: 463-76.
[105]
Baral S, Pariyar R, Kim J, Lee H-S, Seo J. Quercetin-3-O-glucuronide promotes the proliferation and migration of neural stem cells. Neurobiol Aging 2017; 52: 39-52.
[106]
Hwang E-S, Kim H-B, Choi G-Y, et al. Acute rosmarinic acid treatment enhances long-term potentiation, BDNF and GluR-2 protein expression, and cell survival rate against scopolamine challenge in rat organotypic hippocampal slice cultures. Biochem Biophys Res Commun 2016; 475(1): 44-50.
[107]
Xu P-, Wang S-W, Yu X-l, et al Rutin improves spatial memory in Alzheimer’s disease transgenic mice by reducing Aβ oligomer level and attenuating oxidative stress and neuroinflammation. Behav Brain Res 2014; 264: 173-80.
[108]
Cao YY, Wang L, Ge H, et al. Salvianolic acid A, a polyphenolic derivative from Salvia miltiorrhiza bunge, as a multifunctional agent for the treatment of Alzheimer’s disease. Mol Divers 2013; 17(3): 515-24.
[109]
Tang Y, Huang D, Zhang M-H, et al. Salvianolic acid B inhibits Aβ generation by modulating BACE1 activity in SH-SY5Y-APPsw Cells Nutrients 2016. 8(6): 333.
[110]
Durairajan SSK, Yuan Q, Xie L, et al. Salvianolic acid B inhibits Aβ fibril formation and disaggregates preformed fibrils and protects against Aβ-induced cytotoxicty. Neurochem Int 2008; 52(4): 741-50.
[111]
Richard T, Papastamoulis Y, Waffo-Teguo P, Monti J-P. 3D NMR structure of a complex between the amyloid beta peptide (1–40) and the polyphenol ε-viniferin glucoside: Implications in Alzheimer’s disease. Biochim Biophys Acta 2013; 1830(11): 5068-74.
[112]
Yu Y, Zhou L, Sun M, et al. Xylocoside G reduces amyloid-β induced neurotoxicity by inhibiting NF-κB signaling pathway in neuronal cells. J Alzheimers Dis 2012; 30(2): 263-75.
[113]
Wang Z, Zhang X, Wang H, Qi L, Lou Y. Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway. NeuroSci 2007; 145(3): 911-22.
[114]
Park S-Y, Lim J-Y, Jeong W, et al. C-methylflavonoids isolated from Callistemon lanceolatus protect PC12 cells against Aβ-induced toxicity. Planta Med 2010; 76(09): 863-8.
[115]
Ono K, Yoshiike Y, Takashima A, et al. Potent anti‐amyloidogenic and fibril‐destabilizing effects of polyphenols in vitro: Implications for the prevention and therapeutics of Alzheimer’s disease. J Neurochem 2003; 87(1): 172-81.
[116]
Cox CJ, Choudhry F, Peacey E, et al. Dietary (−)-epicatechin as a potent inhibitor of βγ-secretase amyloid precursor protein processing. Neurobiol Aging 2015; 36(1): 178-87.
[117]
Li F, Dong H, Gong Q, et al. Icariin decreases both APP and Aβ levels and increases neurogenesis in the brain of Tg2576 mice. Neurosci 2015; 304: 29-35.
[118]
Yin C, Deng Y, Gao J, et al. Icariside II, a novel phosphodiesterase-5 inhibitor, attenuates streptozotocin-induced cognitive deficits in rats. Neurosci 2016; 328: 69-9.
[119]
Liu R, Gao M, Qiang G-F, et al. The anti-amnesic effects of luteolin against amyloid β 25–35 peptide-induced toxicity in mice involve the protection of neurovascular unit. Neurosci 2009; 162(4): 1232-43.
[120]
Meyer E, Mori MA, Campos AC, et al. Myricitrin induces antidepressant-like effects and facilitates adult neurogenesis in mice. Behav Brain Res 2017; 316: 59-65.
[121]
Kim DH, Lee Y, Lee HE, et al. Oroxylin A enhances memory consolidation through the brain-derived neurotrophic factor in mice. Brain Res Bull 2014; 108: 67-73.
[122]
Lin Y-L, Tsay H-J, Liao Y-F, et al. The components of Flemingia macrophylla attenuate amyloid β-protein accumulation by regulating amyloid β-protein metabolic pathwayEvid Based Complement Alternat Med 2012; 2012.
[123]
Sarkar N, Kumar M, Dubey VK. Rottlerin dissolves pre-formed protein amyloid: A study on hen egg white lysozyme. Biochim Biophys Acta 2011; 1810(9): 809-14.
[124]
Duan S, Guan X, Lin R, et al. Silibinin inhibits acetylcholinesterase activity and amyloid β peptide aggregation: a dual-target drug for the treatment of Alzheimer’s disease. Neurobiol Aging 2015; 36(5): 1792-807.
[125]
Chang R, Chao J, Yu M, Wang M. Neuroprotective effects of oxyresveratrol from fruit against neurodegeneration in Alzheimer's diseaseRec Adv Nutrition Prevent Alzheimer's Disease 2010 2010.
[126]
Choi B, Kim S, Jang B-G, Kim M-J. Piceatannol, a natural analogue of resveratrol, effectively reduces beta-amyloid levels via activation of alpha-secretase and matrix metalloproteinase-9. J Funct Foods 2016; 23: 124-4.
[127]
Wang R, Zhang Y, Li J, Zhang C. Resveratrol ameliorates spatial learning memory impairment induced by Aβ 1–42 in rats. Neurosci 2017; 344: 39-47.
[128]
Misiti F, Sampaolese B, Mezzogori D, et al. Protective effect of rhubarb derivatives on amyloid beta (1–42) peptide-induced apoptosis in IMR-32 cells: A case of nutrigenomic. Brain Res Bull 2006; 71(1): 29-36.
[129]
Cui Y-M, Wang H, Liu Q-R, et al. Flavans from Iris tenuifolia and their effects on β-amyloid aggregation and neural stem cells proliferation in vitro. Bioorg Med Chem Lett 2011; 21(15): 4400-3.
[130]
Balez R, Steiner N, Engel M, et al. Neuroprotective effects of apigenin against inflammation, neuronal excitability and apoptosis in an induced pluripotent stem cell model of Alzheimer’s disease. Scientif Reports 2016; p. 6.
[131]
Yin F, Liu J, Ji X, et al. Baicalin prevents the production of hydrogen peroxide and oxidative stress induced by Aβ aggregation in SH-SY5Y cells. Neurosci Lett 2011; 492(2): 76-9.
[132]
Zhang SQ, Obregon D, Ehrhart J, et al. Baicalein reduces β‐amyloid and promotes nonamyloidogenic amyloid precursor protein processing in an Alzheimer’s disease transgenic mouse model. J Neurosci Res 2013; 91(9): 1239-46.
[133]
Gu X-H, Xu L-J, Liu Z-Q, et al. The flavonoid baicalein rescues synaptic plasticity and memory deficits in a mouse model of Alzheimer’s disease. Behav Brain Res 2016; 311: 309-21.
[134]
Ushikubo H, Watanabe S, Tanimoto Y, et al. 3, 3′, 4′, 5, 5′-Pentahydroxyflavone is a potent inhibitor of amyloid β fibril formation. Neurosci Lett 2012; 513(1): 51-6.
[135]
Cho JK, Ryu YB, Curtis-Long MJ, et al. Inhibition and structural reliability of prenylated flavones from the stem bark of Morus lhou on β-secretase (BACE-1). Bioorg Med Chem Lett 2011; 21(10): 2945-8.
[136]
Cahlíková L, Macáková Ki, Benešová N, et al. Natural compounds (small molecules) as potential and real drugs of Alzheimers disease: a critical review. Studies Nat Products Chem 2014; 42: 153-94.
[137]
Du Y, Qu J, Zhang W, et al. Morin reverses neuropathological and cognitive impairments in APPswe/PS1dE9 mice by targeting multiple pathogenic mechanisms. Neuropharmacology 2016; 108: 1-13.
[138]
Gupta G, Chellappan D, Agarwal M, et al. Pharmacological evaluation of the recuperative effect of morusin against aluminium trichloride (alcl3)-induced memory impairment in rats. Cent Nerv Syst Agents Med Chem 2017; 17(3): 196-200.
[139]
Taniguchi S, Suzuki N, Masuda M, et al. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J Biol Chem 2005; 280(9): 7614-23.
[140]
Necula M, Kayed R, Milton S, Glabe CG. Small molecule inhibitors of aggregation indicate that amyloid β oligomerization and fibrillization pathways are independent and distinct. J Biol Chem 2007; 282(14): 10311-24.
[141]
Saito S, Yamamoto Y, Maki T, et al. Taxifolin inhibits amyloid-β oligomer formation and fully restores vascular integrity and memory in cerebral amyloid angiopathy. Acta Neuropathol Commun 2017; 5(1): 26.
[142]
Lou H, Fan P, Perez RG, Lou H. Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death. Bioorg Med Chem 2011; 19(13): 4021-7.
[143]
Tao J, Zhao J, Zhao Y, Cui Y, Fang W. BACE inhibitory flavanones from Balanophora involucrata Hook. F. Fitoterapia 2012; 83(8): 1386-90.
[144]
Li C, Zug C, Qu H, Schluesener H, Zhang Z. Hesperidin ameliorates behavioral impairments and neuropathology of transgenic APP/PS1 mice. Behav Brain Res 2015; 281: 32-42.
[145]
Hwang EM, Ryu YB, Kim HY, et al. BACE1 inhibitory effects of lavandulyl flavanones from Sophora flavescens. Bioorg Med Chem 2008; 16(14): 6669-74.
[146]
Ghofrani S, Joghataei M-T, Mohseni S, et al. Naringenin improves learning and memory in an Alzheimer’s disease rat model: Insights into the underlying mechanisms. Eur J Pharmacol 2015; 764: 195-201.
[147]
Wang Y, Miao Y, Mir AZ, et al. Inhibition of beta-amyloid-induced neurotoxicity by pinocembrin through Nrf2/HO-1 pathway in SH-SY5Y cells. J Neurol Sci 2016; 368: 223-30.
[148]
Youn K, Lee J, Ho C-T, Jun M. Discovery of polymethoxyflavones from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors. J Funct Foods 2016; 20: 567-74.
[149]
Tan JW, Kim MK. Neuroprotective effects of Biochanin A against β-amyloid-induced neurotoxicity in PC12 cells via a mitochondrial-dependent apoptosis pathway. Molecules 2016; 21(5): 548.
[150]
Youn K, Park J-H, Lee J, et al. The identification of biochanin A as a potent and selective β-site app-cleaving enzyme 1 (Bace1) inhibitor. Nutrients 2016; 8(10): 637.
[151]
Chen L, Ou S, Zhou L, et al. Formononetin attenuates Aβ 25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP. Neurosci Lett 2017; 639: 36-42.
[152]
Liao W, Jin G, Zhao M, Yang H. The effect of genistein on the content and activity of α‐and β‐secretase and protein kinase c in aβ‐injured hippocampal neurons. Basic Clin Pharmacol Toxicol 2013; 112(3): 182-5.
[153]
You F, Li Q, Jin G, et al. Genistein protects against Aβ 25–35 induced apoptosis of PC12 cells through JNK signaling and modulation of Bcl-2 family messengers. BMC Neurosci 2017; 18(1): 12.
[154]
Wei L, Lv S, Huang Q, et al. Pratensein attenuates Aβ-induced cognitive deficits in rats: Enhancement of synaptic plasticity and cholinergic function. Fitoterapia 2015; 101: 208-17.
[155]
Zou Y, Hong B, Fan L, et al. Protective effect of puerarin against beta-amyloid-induced oxidative stress in neuronal cultures from rat hippocampus: involvement of the GSK-3β/Nrf2 signaling pathway. Free Radic Res 2013; 47(1): 55-63.
[156]
de Oliveira JS, Abdalla FH, Dornelles GL, et al. Berberine protects against memory impairment and anxiogenic-like behavior in rats submitted to sporadic Alzheimer’s-like dementia: Involvement of acetylcholinesterase and cell death. Neurotoxicology 2016; 57: 241-50.
[157]
Shigeta K, Ootaki K, Tatemoto H, et al. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by a Coptidis Rhizoma extract and protoberberine alkaloids. Biosci Biotechnol Biochem 2002; 66(11): 2491-4.
[158]
Durairajan SSK, Liu L-F, Lu J-H, et al. Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer’s disease transgenic mouse model. Neurobiol Aging 2012; 33(12): 2903-19.
[159]
Park CH, Lee YJ, Lee SH, et al. Dehydroevodiamine· HCl prevents impairment of learning and memory and neuronal loss in rat models of cognitive disturbance. J Neurochem 2000; 74(1): 244-53.
[160]
Fang J, Liu R, Tian Q. Dehydroevodiamine attenuates calyculin A‐induced tau hyperphos‐phorylation in rat brain slices. Acta Pharmacol Sin 2007; 28(11): 1717-23.
[161]
Ma T, Gong K, Yan Y, et al. Huperzine A promotes hippocampal neurogenesis in vitro and in vivo. Brain Res 2013; 1506: 35-43.
[162]
Xian Y-F, Mao Q-Q, Wu JC, et al. Isorhynchophylline treatment improves the amyloid-β-induced cognitive impairment in rats via inhibition of neuronal apoptosis and tau protein hyperphosphorylation. J Alzheimers Dis 2014; 39(2): 331-46.
[163]
Chonpathompikunlert P, Wattanathorn J, Muchimapura S. Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer’s disease. Food Chem Toxicol 2010; 48(3): 798-802.
[164]
Fu AK, Hung K-W, Huang H, et al. Blockade of EphA4 signaling ameliorates hippocampal synaptic dysfunctions in mouse models of Alzheimer’s disease. Proc Natl Acad Sci 2014; 111(27): 9959-64.
[165]
Shukla SM, Sharma SK. Sinomenine inhibits microglial activation by Aβ and confers neuroprotection. J Neuroinflammation 2011; 8(1): 117.
[166]
He F-Q, Qiu B-Y, Zhang X-H, et al. Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer’s disease induced by amyloid-β (1–42). Brain Res 2011; 1384: 89-96.
[167]
Viet MH, Chen C-Y, Hu C-K, Chen Y-R, Li MS. Discovery of dihydrochalcone as potential lead for Alzheimer’s disease: In silico and in vitro study. PLoS One 2013; 8(11): e79151.
[168]
Chen H-H, Chen Y-T, Huang Y-W, Tsai H-J, Kuo C-C. 4-Ketopinoresinol, a novel naturally occurring ARE activator, induces the Nrf2/HO-1 axis and protects against oxidative stress-induced cell injury via activation of PI3K/AKT signaling. Free Radic Biol Med 2012; 52(6): 1054-66.
[169]
Lee Y-J, Choi D-Y, Choi IS, et al. Inhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models. J Neuroinflammation 2012; 9(1): 35.
[170]
Zhu Z, Yan J, Jiang W, et al. Arctigenin effectively ameliorates memory impairment in Alzheimer’s disease model mice targeting both β-amyloid production and clearance. J Neurosci 2013; 33(32): 13138-49.
[171]
Xian Y-F, Ip S-P, Mao Q-Q, Lin Z-X. Neuroprotective effects of honokiol against beta-amyloid-induced neurotoxicity via GSK-3β and β-catenin signaling pathway in PC12 cells. Neurochem Int 2016; 97: 8-14.
[172]
Siddique YH, Ali F. Protective effect of nordihydroguaiaretic acid (NDGA) on the transgenic Drosophila Model of Alzheimer’s disease. Chem Biol Interact 2017; 269: 59-66.
[173]
Hu D, Cao Y, He R, et al. Schizandrin, an antioxidant lignan from Schisandra chinensis, ameliorates Aβ 1–42-induced memory impairment in mice. Oxidative Med Cellul Longevity 2012. 2012
[174]
Mao X, Liao Z, Guo L, et al. Schisandrin C ameliorates learning and memory deficits by aβ1–42‐induced oxidative stress and neurotoxicity in mice. Phytother Res 2015; 29(9): 1373-80.
[175]
Li X, Zhao X, Xu X, et al. Schisantherin A recovers Aβ-induced neurodegeneration with cognitive decline in mice. Physiol Behav 2014; 132: 10-6.
[176]
Katayama S, Sugiyama H, Kushimoto S, et al. Effects of sesaminol feeding on brain aβ accumulation in a senescence-accelerated mouse-prone 8. J Agric Food Chem 2016; 64(24): 4908-13.
[177]
Tohda C, Matsumoto N, Zou K, Meselhy MR, Komatsu K. A [beta](25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins. Neuropsychopharmacology 2004; 29(5): 860.
[178]
Yu X, Wang L-n, Du Q-m, et al. Akebia Saponin D attenuates amyloid β-induced cognitive deficits and inflammatory response in rats: Involvement of Akt/NF-κB pathway. Behav Brain Res 2012; 235(2): 200-9.
[179]
Yu X, Wang L-n, Ma L, et al. Akebia saponin D attenuates ibotenic acid-induced cognitive deficits and pro-apoptotic response in rats: involvement of MAPK signal pathway. Pharmacol Biochem Behav 2012; 101(3): 479-86.
[180]
Liu J, He J, Huang L, et al. Neuroprotective effects of ginsenoside Rb1 on hippocampal neuronal injury and neurite outgrowth. Neural Regen Res 2014; 9(9): 943.
[181]
Li L, Liu Z, Liu J, et al. Ginsenoside Rd attenuates beta-amyloid-induced tau phosphorylation by altering the functional balance of glycogen synthase kinase 3beta and protein phosphatase 2A. Neurobiol Dis 2013; 54: 320-8.
[182]
Tohda C, Kuboyama T, Komatsu K. Search for natural products related to regeneration of the neuronal network. Neurosignals 2005; 14(1-2): 34-45.
[183]
Zhong L, Tan J, Ouyang S, Xu J. Effects of Saponin B from Anemarrhena asphodeloides Bunge on tau hyperphosphorylation induced by beta-amyloid peptide (25-35) in rats. Nan fang yi ke da xue xue bao= J Southern Med Uni 2006. 26(8): 1106-9
[184]
Zhang H, Han T, Zhang L, et al. Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice. Phytomedicine 2008; 15(8): 587-94.
[185]
Cao G, Su P, Zhang S, et al. Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells. Eur J Pharmacol 2016; 793: 101-8.
[186]
Jeong YH, Van Le TK, Kim HS. Kalopanaxsaponin A exerts anti-inflammatory effects in lipopolysaccharide-stimulated microglia via inhibition of JNK and NF-κB/AP-1 pathways. Biomol Ther 2013; 21(5): 332-7.
[187]
Joh EH, Lee IA, Kim DH. Kalopanaxsaponins A and B isolated from Kalopanax pictus ameliorate memory deficits in mice. Phytother Res 2012; 26(4): 546-51.
[188]
Jung I-H, Jang S-E, Joh E-H, et al. Lancemaside A isolated from Codonopsis lanceolata and its metabolite echinocystic acid ameliorate scopolamine-induced memory and learning deficits in mice. Phytomedicine 2012; 20(1): 84-8.
[189]
Lin X, Zhang S, Huang R, et al. Protective effect of madecassoside against cognitive impairment induced by D-galactose in mice. Pharmacol Biochem Behav 2014; 124: 434-42.
[190]
Hur J, Lee P, Moon E, et al. Neurite outgrowth induced by spicatoside A, a steroidal saponin, via the tyrosine kinase A receptor pathway. Eur J Pharmacol 2009; 620(1): 9-15.
[191]
Lee B, Jung K, Kim D-H. Timosaponin AIII, a saponin isolated from Anemarrhenaasphodeloides, ameliorates learning and memory deficits in mice. Pharmacol Biochem Behav 2009; 93(2): 121-7.
[192]
Huang J-F, Shang L, Liu P, et al. Timosaponin-BII inhibits the up-regulation of BACE1 induced by ferric chloride in rat retina. BMC Complement Altern Med 2012; 12(1): 189.
[193]
Hur JY, Lee P, Kim H, Kang I, Lee KR, Kim SY. (−)-3, 5-Dicaffeoyl-muco-quinic acid isolated from Aster scaber contributes to the differentiation of PC12 cells: Through tyrosine kinase cascade signaling. Biochem Biophys Res Commun 2004; 313(4): 948-53.
[194]
Lomarat P, Chancharunee S, Anantachoke N, et al. Bioactivity-guided separation of the active compounds in acacia pennata responsible for the prevention of alzheimer’s disease. Nat Prod Commun 2015; 10(8): 1431-4.
[195]
Ho CC, Kumaran A, Hwang LS. Bio-assay guided isolation and identification of anti-Alzheimer active compounds from the root of Angelica sinensis. Food Chem 2009; 114(1): 246-52.
[196]
Shi C, Liu J, Wu F, et al. β-sitosterol inhibits high cholesterol-induced platelet β-amyloid release. J Bioenerg Biomembr 2011; 43(6): 691-7.
[197]
Iuvone T, Esposito G, Esposito R, et al. Neuroprotective effect of cannabidiol, a non‐psychoactive component from Cannabis sativa, on β‐amyloid‐induced toxicity in PC12 cells. J Neurochem 2004; 89(1): 134-41.
[198]
Esposito G, Scuderi C, Valenza M, Togna G, Latina V. Cannabidiol Reduces Ab-Induced Neuroinflammation and Promotes Hippocampal 2011; 6(12): e28668.
[199]
Jiang XY, Zhang JT. Study on the nootropic mechanism of (-) clausenamide-influence on the formation of synapses in mouse brain. J Asian Nat Prod Res 1998; 1(1): 53-8.
[200]
Hu J-F, Niu F, Ning N, et al. Activation of ERK1/2-CREB pathway during potentiating synaptic transmission of (−) clausenamide in rat dentate gyrus. J Asian Nat Prod Res 2012; 14(3): 256-62.
[201]
Hu J-F, Chu S-F, Ning N, et al. Protective effect of (−) clausenamide against Aβ-induced neurotoxicity in differentiated PC12 cells. Neurosci Lett 2010; 483(1): 78-82.
[202]
Asadi F, Jamshidi AH, Khodagholi F, et al. Reversal effects of crocin on amyloid β-induced memory deficit: modification of autophagy or apoptosis markers. Pharmacol Biochem Behav 2015; 139: 47-58.
[203]
Morelli S, Salerno S, Piscioneri A, Tasselli F, Drioli E, De Bartolo L. Neuronal membrane bioreactor as a tool for testing crocin neuroprotective effect in Alzheimer’s disease. Chem Eng J 2016.
[204]
Chauhan NB. Effect of aged garlic extract on APP processing and tau phosphorylation in Alzheimer’s transgenic model Tg2576. J Ethnopharmacol 2006; 108(3): 385-94.
[205]
Zarezadeh M, Baluchnejadmojarad T, Kiasalari Z, Afshin-Majd S, Roghani M. Garlic active constituent s-allyl cysteine protects against lipopolysaccharide-induced cognitive deficits in the rat: possible involved mechanisms. Eur J Pharmacol 2017; 795: 13-21.
[206]
Pickhardt M, Gazova Z, von Bergen M, et al. Anthraquinones inhibit tau aggregation and dissolve Alzheimer’s paired helical filaments in vitro and in cells. J Biol Chem 2005; 280(5): 3628-35.
[207]
Sun Y-P, Liu J-P. Blockade of emodin on amyloid-β25–35-induced neurotoxicity in aβpp/ps1 mice and pc12 cells through activation of the class iii phosphatidylinositol 3-kinase/beclin-1/b-cell lymphoma 2 pathway. Planta Med 2015; 81(02): 108-15.
[208]
Zhang M, Wang Y, Qian F, Li P, Xu X. Hypericin inhibits oligomeric amyloid β42-induced inflammation response in microglia and ameliorates cognitive deficits in an amyloid β injection mouse model of Alzheimer’s disease by suppressing MKL1. Biochem Biophys Res Commun 2016; 481(1): 71-6.
[209]
Wang P, Liao W, Fang J, et al. A glucan isolated from flowers of lonicera japonica thunb. Inhibits aggregation and neurotoxicity of Aβ 42. Carbohydr Polym 2014; 110: 142-7.
[210]
Yin Q, Ma Y, Hong Y, et al. Lycopene attenuates insulin signaling deficits, oxidative stress, neuroinflammation, and cognitive impairment in fructose-drinking insulin resistant rats. Neuropharmacology 2014; 86: 389-96.
[211]
Shih P-H, Wu C-H, Yeh C-T, Yen G-C. Protective effects of anthocyanins against amyloid β-peptide-induced damage in neuro-2A cells. J Agric Food Chem 2011; 59(5): 1683-9.
[212]
Nie B-M, Jiang X-Y, Cai J-X, et al. Panaxydol and panaxynol protect cultured cortical neurons against Aβ25–35-induced toxicity. Neuropharmacology 2008; 54(5): 845-53.
[213]
Wang Z-J, Nie B-M, Chen H-Z, Lu Y. Panaxynol induces neurite outgrowth in PC12D cells via cAMP-and MAP kinase-dependent mechanisms. Chem Biol Interact 2006; 159(1): 58-64.
[214]
Gao J, He H, Jiang W, et al. Salidroside ameliorates cognitive impairment in a d-galactose-induced rat model of Alzheimer’s disease. Behav Brain Res 2015; 293: 27-33.
[215]
Li Q-Y, Wang H-M, Wang Z-Q, et al. Salidroside attenuates hypoxia-induced abnormal processing of amyloid precursor protein by decreasing BACE1 expression in SH-SY5Y cells. Neurosci Lett 2010; 481(3): 154-8.
[216]
Giridharan VV, Thandavarayan RA, Arumugam S, et al. Schisandrin B ameliorates ICV-infused amyloid β induced oxidative stress and neuronal dysfunction through inhibiting rage/nf-κb/mapk and up-regulating hsp/beclin expression. PLoS One 2015; 10(11): e0142483.
[217]
Wang Q, Yu X, Patal K, et al. Tanshinones inhibit amyloid aggregation by amyloid-β peptide, disaggregate amyloid fibrils, and protect cultured cells. ACS Chem Neurosci 2013; 4(6): 1004-15.
[218]
Shi L-L, Yang W-N, et al. The protective effects of tanshinone IIA on neurotoxicity induced by β-amyloid protein through calpain and the p35/Cdk5 pathway in primary cortical neurons. Neurochem Int 2012; 61(2): 227-35.
[219]
Chen Y, Huang X, Chen W, Wang N, Li L. Tenuigenin promotes proliferation and differentiation of hippocampal neural stem cells. Neurochem Res 2012; 37(4): 771-7.
[220]
Alhebshi A, Gotoh M, Suzuki I. Thymoquinone protects cultured rat primary neurons against amyloid β-induced neurotoxicity. Biochem Biophys Res Commun 2013; 433(4): 362-7.
[221]
Kim TI, Lee YK, Park SG, et al. l-Theanine, an amino acid in green tea, attenuates β-amyloid-induced cognitive dysfunction and neurotoxicity: Reduction in oxidative damage and inactivation of ERK/p38 kinase and NF-κB pathways. Free Radic Biol Med 2009; 47(11): 1601-10.
[222]
Xu W, Yang L, Li J. Protection against β-amyloid-induced neurotoxicity by naturally occurring Z-ligustilide through the concurrent regulation of p38 and PI3-K/Akt pathways. Neurochem Int 2016; 100: 44-51.
[223]
Zhang Y, Huang LJ, Shi S, et al. L‐3‐n‐butylphthalide rescues hippocampal synaptic failure and attenuates neuropathology in aged APP/PS1 mouse model of Alzheimer’s disease. CNS Neurosci Ther 2016; 22(12): 979-87.
[224]
Chang C-Y, Chen S-M, Lu H-E, et al. N-butylidenephthalide attenuates Alzheimer’s disease-like cytopathy in Down syndrome induced pluripotent stem cell-derived neurons. Sci Rep 2015; 5: 8744.
[225]
Li L, Li W, Jung S-W, Lee Y-W, Kim Y-H. Protective effects of decursin and decursinol angelate against amyloid β-protein-induced oxidative stress in the PC12 cell line: The role of Nrf2 and antioxidant enzymes. Biosci Biotechnol Biochem 2011; 75(3): 434-42.
[226]
Kim JK, Choi SJ, Bae H, et al. Effects of methoxsalen from Poncirus trifoliata on acetylcholinesterase and trimethyltin-induced learning and memory impairment. Biosci Biotechnol Biochem 2011; 75(10): 1984-9.
[227]
Meineck M, Schuck F, Abdelfatah S, Efferth T, Endres K. Identification of Phlogacantholide C as a Novel ADAM10 Enhancer from Traditional Chinese Medicinal Plants. Medicines 2016; 3(4): 30.
[228]
Kurisu M, Miyamae Y, Murakami K, et al. Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside. Biosci Biotechnol Biochem 2013; 77(6): 1329-32.
[229]
Ma B, Meng X, Wang J, et al. Notoginsenoside R1 attenuates amyloid-β-induced damage in neurons by inhibiting reactive oxygen species and modulating MAPK activation. Int Immunopharmacol 2014; 22(1): 151-9.
[230]
Quan Q, Wang J, Li X, Wang Y. Ginsenoside Rg1 decreases aβ1–42 level by upregulating pparγ and ide expression in the hippocampus of a rat model of Alzheimer’s disease. PLoS One 2013; 8(3): e59155.
[231]
Jayaprakasam B, Padmanabhan K, Nair MG. Withanamides in Withania somnifera fruit protect PC‐12 cells from β‐amyloid responsible for Alzheimer’s disease. Phytother Res 2010; 24(6): 859-63.
[232]
Kuboyama T, Tohda C, Komatsu K. Neuritic regeneration and synaptic reconstruction induced by withanolide A. Br J Pharmacol 2005; 144(7): 961-71.
[233]
Kuboyama T, Tohda C, Komatsu K. Withanoside IV and its active metabolite, sominone, attenuate Aβ (25–35)‐induced neurodegeneration. Eur J Neurosci 2006; 23(6): 1417-26.
[234]
Kuboyama T, Tohda C, Zhao J, et al. Axon-or dendrite-predominant outgrowth induced by constituents from Ashwagandha. Neuroreport 2002; 13(14): 1715-20.
[235]
Pedraza-Chaverrí J, Reyes-Fermín LM, Nolasco-Amaya EG, et al. ROS scavenging capacity and neuroprotective effect of α-mangostin against 3-nitropropionic acid in cerebellar granule neurons. Exp Toxicol Pathol 2009; 61(5): 491-501.
[236]
Wang Y, Xia Z, Xu J-R, et al. α-Mangostin, a polyphenolic xanthone derivative from mangosteen, attenuates β-amyloid oligomers-induced neurotoxicity by inhibiting amyloid aggregation. Neuropharmacology 2012; 62(2): 871-81.
[237]
Wang H, Xu Y, Yan J, et al. Acteoside protects human neuroblastoma SH-SY5Y cells against β-amyloid-induced cell injury. Brain Res 2009; 1283: 139-47.
[238]
Patil SP, Maki S, Khedkar SA, Rigby AC, Chan C. Withanolide A and asiatic acid modulate multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance. J Nat Prod 2010; 73(7): 1196-202.
[239]
Tchantchou F, Lacor PN, Cao Z, et al. Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons. J Alzheimers Dis 2009; 18(4): 787-98.
[240]
Shi C, Wu F, Yew DT, Xu J, Zhu Y. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Apoptosis 2010; 15(6): 715-27.
[241]
Rasoolijazi H, Azad N, Joghataei M, et al. The protective role of carnosic acid against beta-amyloid toxicity in rats Scientific World J 2013 2013.
[242]
Mei Z, Yan P, Situ B, Mou Y, Liu P. Cryptotanshinione inhibits β-amyloid aggregation and protects damage from β-amyloid in SH-SY5Y Cells. Neurochem Res 2012; 37(3): 622-8.
[243]
Mei Z, Zhang F, Tao L, et al. Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates β-amyloid deposition through upregulating α-secretase in vivo and in vitro. Neurosci Lett 2009; 452(2): 90-5.
[244]
Bate C, Tayebi M, Williams A. Ginkgolides protect against amyloid-β 1–42-mediated synapse damage in vitro. Mol Neurodegener 2008; 3(1): 1.
[245]
Xie H, Wang J-R, Yau L-F, et al. Quantitative analysis of the flavonoid glycosides and terpene trilactones in the extract of Ginkgo biloba and evaluation of their inhibitory activity towards fibril formation of β-amyloid peptide. Molecules 2014; 19(4): 4466-78.
[246]
Xiao Q, Wang C, Li J, et al. Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25–35 partly via up-regulation of brain-derived neurotrophic factor. Eur J Pharmacol 2010; 647(1): 48-54.
[247]
Vitolo O, Gong B, Cao Z, et al. Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J. Neurobiol Aging 2009; 30(2): 257-65.
[248]
Li P, Matsunaga K, Yamamoto K. Nardosinone, a novel enhancer of nerve growth factor in neurite outgrowth from PC12D cells. Neurosci Lett 1999; 273(1): 53-6.
[249]
Zeng Y, Zhang J, Zhu Y, et al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse‐related proteins in a transgenic model of Alzheimer’s Disease. J Neurochem 2015; 133(1): 38-52.
[250]
Wang Y-J, Lu J, Wu D-m, et al. Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways. Neurobiol Learn Mem 2011; 96(2): 156-65.
[251]
Nam SM, Choi JH, Yoo DY, et al. Valeriana officinalis extract and its main component, valerenic acid, ameliorate D-galactose-induced reductions in memory, cell proliferation, and neuroblast differentiation by reducing corticosterone levels and lipid peroxidation. Exp Gerontol 2013; 48(11): 1369-77.
[252]
Ji D, Zhang C, Li J. A new iridoid glycoside from the roots of Dipsacus asper. Molecules 2012; 17(2): 1419-24.
[253]
Yamazaki M, Chiba K, Mohri T. Neuritogenic effect of natural iridoid compounds on PC12h cells and its possible relation to signaling protein kinases. Biol Pharm Bull 1996; 19(6): 791-5.
[254]
Zhang Y, Xia Z, Liu J, Yin F. Cell signaling mechanisms by which geniposide regulates insulin-degrading enzyme expression in primary cortical neurons. CNS Neurol Disord Drug Targets 2015; 14(3): 370-7.
[255]
Zhao C, Lv C, Li H, et al. Geniposide protects primary cortical neurons against oligomeric Aβ1-42-induced neurotoxicity through a mitochondrial pathway. PLoS One 2016; 11(4): e0152551.
[256]
Youn K, Jeong W-S, Jun M. β-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus. Nat Prod Res 2013; 27(16): 1471-4.
[257]
Pitt J, Roth W, Lacor P, et al. Alzheimer’s-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicol Appl Pharmacol 2009; 240(2): 189-97.
[258]
Abuznait AH, Qosa H, Busnena BA, El Sayed KA, Kaddoumi A. Olive-oil-derived oleocanthal enhances β-amyloid clearance as a potential neuroprotective mechanism against Alzheimer’s disease: in vitro and in vivo studies. ACS Chem Neurosci 2013; 4(6): 973-82.
[259]
Grossi C, Rigacci S, Ambrosini S, et al. The polyphenol oleuropein aglycone protects TgCRND8 mice against Aß plaque pathology. PLoS One 2013; 8(8): e71702.
[260]
Li P, Matsunaga K, Yamakuni T, Ohizumi Y. Potentiation of nerve growth factor-action by picrosides I and II, natural iridoids, in PC12D cells. Eur J Pharmacol 2000; 406(2): 203-8.

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