Sarcosine as a Novel and Recyclable Organocatalyst: A Greener Approach Towards the Synthesis of Multisubstituted Pyrazole Derivatives

Author(s): Deepali Jaiswal, Jyoti Tiwari, Shailesh Singh, Amit Kumar Sharma, Jaya Singh, Jagdamba Singh*.

Journal Name: Current Organocatalysis

Volume 5 , Issue 3 , 2018

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Abstract:

Background: A highly efficient eco-friendly route for the synthesis of pyrazole derivatives from readily available chalcones/1, 3-diketones and hydrazines in glycerol using sarcosine as a novel organopromoter has been developed. To the best of our knowledge this is the first report on the use of sarcosine as an organocatalyst in organic transformations.

Results and Methods: This method manifests several attributes of green chemistry like atomeconomy, reusability of catalyst, short reaction time and an eco-friendly medium.

Conclusion: The present protocol can serve as a valuable green alternative to the existing methods for the synthesis of targeted molecules.

Keywords: Catalysis, glycerol, green synthesis, pyrazole, sarcosine.

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Article Details

VOLUME: 5
ISSUE: 3
Year: 2018
Page: [229 - 238]
Pages: 10
DOI: 10.2174/2213337205666180810123412

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