Breast Cancer Stem Cells and Sex Steroid Hormones

Author(s): Iván Flores-Ramírez , Noemi Baranda-Avila* , Elizabeth Langley .

Journal Name: Current Stem Cell Research & Therapy

Volume 14 , Issue 5 , 2019

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Abstract:

Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes breast cancer stem cell origin, signaling pathways involved in self-renewal, such as Wnt, Notch and Hedgehog, biomarkers linked to stemness, and the role of sex steroid hormones in BCSC regulation.

Keywords: Breast cancer, breast cancer stem cells, biomarkers, signaling pathways, estrogen receptor, progesterone receptor.

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Article Details

VOLUME: 14
ISSUE: 5
Year: 2019
Page: [398 - 404]
Pages: 7
DOI: 10.2174/1574888X13666180810121415
Price: $58

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