Role of Neuropeptides in the Regulation of the Insect Immune System – Current Knowledge and Perspectives

Author(s): Arkadiusz Urbanski*, Grzegorz Rosinski.

Journal Name: Current Protein & Peptide Science

Volume 19 , Issue 12 , 2018

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Graphical Abstract:


Despite much research on the insect immune system, hormonal regulation of its activity is not well-understood. Previous research on insect neuroendocrinology suggests that neuropeptides may play an important role in the regulation of the insect immune system. Especially recent studies dealing for example with adipokinetic hormones, bursicon or insulin-like peptides provided deeper insights on this issue showing that neuropeptides can modulate various aspects of insect immune responses, both at the molecular and cellular level.

The presented review summarizes the current knowledge about the role of neuropeptides regulating the insect immune system activity. Based on structural and functional homology of some vertebrate and insect neuropeptide families, several propositions of insect neuropeptides that might also possess immunotropic activities, but have not been examined for this aspect, are discussed.

Keywords: Immune system, immune pathways, insects, neuropeptides, neuroendocrinology, hormonal regulation.

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Article Details

Year: 2018
Page: [1201 - 1213]
Pages: 13
DOI: 10.2174/1389203719666180809113706
Price: $58

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