Background & Objective: Diabetes and neurodegenerative diseases (ND) are progressive
morbidities and represent a major public health burden. A growing body of evidence points towards
the comorbidity of diabetes and NDs with a possible exacerbation of latter by former. Considering the
high prevalence of both morbidities in aging world population, even a modest impact of diabetes on
NDs could lead to significant public health implications. Several hypotheses and mechanistic evidence
were proposed linking altered glucose metabolism to the risk of progressive dementia. Unregulated
production of reactive oxygen species (ROS) and resultant oxidative stress (OS) are the common features
of diabetes as well as NDs.
Conclusion: This review explores the concept of altered glucose metabolic pathways leading to ROS
increase and its possible link to NDs, with a special emphasis on Alzheimer’s diseases (AD). We also
discuss the detailed mechanistic link between hyperglycemia, ROS generation, and neurodegeneration
to highlight potential therapeutic avenues for better prevention and treatment.
Keywords: Hyperglycemia-induced ROS, ROS/RNS, Oxidative stress, Diabetes, Neurodegenerative disorders, Alzheimer's
diseases (AD)/Parkinson's disease (PD), anti-oxidants, AGE/RAGE.
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