The Action of Polyphenols in Diabetes Mellitus and Alzheimer's Disease: A Common Agent for Overlapping Pathologies

Author(s): Ana C. Silveira, Jane Pires Dias, Vanessa M. Santos, Pedro Fontes Oliveira, Marco G. Alves, Luís Rato, Branca M. Silva*.

Journal Name: Current Neuropharmacology

Volume 17 , Issue 7 , 2019

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Graphical Abstract:


Diabetes Mellitus (DM) and Alzheimer's disease (AD) are two prevalent diseases in modern societies, which are caused mainly by current lifestyle, aging and genetic alterations. It has already been demonstrated that these two diseases are associated, since individuals suffering from DM are prone to develop AD. Conversely, it is also known that individuals with AD are more susceptible to DM, namely type 2 diabetes (T2DM). Therefore, these two pathologies, although completely different in terms of symptomatology, end up sharing several mechanisms at the molecular level, with the most obvious being the increase of oxidative stress and inflammation.

Polyphenols are natural compounds widely spread in fruits and vegetables whose dietary intake has been considered inversely proportional to the incidence of DM and AD. So, it is believed that this group of phytochemicals may have preventive and therapeutic potential, not only by reducing the risk and delaying the development of these pathologies, but also by improving brain’s metabolic profile and cognitive function.

The aim of this review is to understand the extent to which DM and AD are related pathologies, the degree of similarity and the relationship between them, to detail the molecular mechanisms by which polyphenols may exert a protective effect, such as antioxidant and anti-inflammatory effects, and highlight possible advantages of their use as common preventive and therapeutic alternatives.

Keywords: Polyphenols, diabetes mellitus, Alzheimer's disease, diabetes mellitus and alzheimer's disease link, antidiabetic therapy, neuroprotection.

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Year: 2019
Page: [590 - 613]
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DOI: 10.2174/1570159X16666180803162059
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