Background: Aging is a process that affects all living organisms. The transition through
life elicits tissue specific alterations in the functional and structural capabilities of all physiological
systems. In particular, the vasculature is vulnerable to aging specific adaptations which induces
morphological changes and ultimately increases the risk of pathological states. Matrix metalloproteinases
are a group of extremely active enzymes that regulate the age-associated structural changes
of the vasculature which has been regarded as the hallmark of arterial aging. Although this process
in unavoidable, the structural and functional changes to the vasculature that occur as a result of advancing
age can be positively or negatively influenced by our lifestyle choices.
Conclusion: Exercise training has profound effects on the age-associated changes of the arteries
which have been shown to be beneficial in offsetting the detrimental responses of aging. This review
provides a brief synopsis of the matrix metalloproteinase induced alterations of the arteria
during aging and highlights the potential of resistance exercise to influence such changes.
Keywords: Matrix metalloproteinase, resistance training, arterial, aging, extracellular matrix, enzymes.
Rights & PermissionsPrintExport