Efficient Synthetic Protocol and Mechanistic Study of Quinazoline Analogues and their Biological Importance
Pp. 121-146 (26)
Sumit Kumar Panja and Satyen Saha
Our main focus is on the recent developments for the synthesis of highly
functionalized quinazoline derivatives in terms of an efficient, one-pot, eco-friendly,
solvent-free, high yield, cost-effective, multicomponent strategy with the variation of
substrates and catalytic conditions. Further, we have also emphasized on the
mechanistic studies depending upon variation of substrates. Detailed mechanistic
aspects have been established based on isolated intermediates and their single crystal
X-ray structures. The biological importance of selected small quinazoline derivatives
has been highlighted as well. In particular, we have observed that selected quinazolinebased
small molecules show global upregulation of miRNA expression with a selective
enrichment of tumor suppressor miRNAs. Therefore, quinazolines can be used as
scaffolds to design activator of miRNA expression, thus paving the way for the
development of novel anti-cancer drugs.
Anti-cancer drug, Biological activity, Global upregulation of miRNA,
miRNA upregulation, Multicomponent one-pot synthetic protocol, Nitrogen
heterocycle molecules, Quinazoline synthesis.
Department of Chemistry, Institute of Science, Banaras Hindu University, Varanasi-221005, India.