The Regioselective Functionalization of Pyridine at 2,3,4-positions via Carbene Intermediate

Author(s): Aamer Saeed*, Muhammad Zain-ul-Abideen, Muhammad N. Mustafa.

Journal Name: Current Organic Chemistry

Volume 22 , Issue 15 , 2018

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Graphical Abstract:


The synthetic and mechanistic aspects of highly energetic pyridine carbenes (PyCs) are discussed for understanding the regio- and stereoselective functionalization of pyridine at rare sites by applying different C-H bond activation methods. Various transition metals and metalloids are used for the generation of corresponding PyCs followed by the formation of substituted pyridines. The functionalization of most focused 2,3,4- positions of pyridine is described with several applications in the synthesis of drugs and natural products, in single-walled carbon nanotubes (SWNTs) and in dye-sensitized solar cells (DSSCs) as the energy storage compounds.

Keywords: Pyridene carbene, Pyrid-x-ylidene, transition metal catalysis, Chichibabin reaction, triaryl-2-pyridylidine, dye-sensitized solar cells.

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Article Details

Year: 2018
Page: [1536 - 1553]
Pages: 18
DOI: 10.2174/1385272822666180801122219
Price: $58

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