Bacterial Polyphosphate Kinases Revisited: Role in Pathogenesis and Therapeutic Potential

Author(s): Lalit Kumar Gautam, Prince Sharma, Neena Capalash*.

Journal Name: Current Drug Targets

Volume 20 , Issue 3 , 2019

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Abstract:

Bacterial infections have always been an unrestrained challenge to the medical community due to the rise of multi-drug tolerant and resistant strains. Pioneering work on Escherichia coli polyphosphate kinase (PPK) by Arthur Kornberg has generated great interest in this polyphosphate (PolyP) synthesizing enzyme. PPK has wide distribution among pathogens and is involved in promoting pathogenesis, stress management and susceptibility to antibiotics. Further, the absence of a PPK orthologue in humans makes it a potential drug target. This review covers the functional and structural aspects of polyphosphate kinases in bacterial pathogens. A description of molecules being designed against PPKs has been provided, challenges associated with PPK inhibitor design are highlighted and the strategies to enable development of efficient drug against this enzyme have also been discussed.

Keywords: Pathogenesis, virulence factors, stringent response, targeted inhibitor screening, PPK inhibitor, drug designing.

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Article Details

VOLUME: 20
ISSUE: 3
Year: 2019
Page: [292 - 301]
Pages: 10
DOI: 10.2174/1389450119666180801120231
Price: $58

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