Succumbing to Multi-Drug Resistant (MDR) bacteria is a great distress to the recent health
care system. Out of the several attempts that have been made to kill MDR pathogens, a few gained
short-lived success. The failures, of the discovered or innovated antimicrobials, were mostly due to
their high level of toxicity to hosts and the phenomenal rate of developing resistance by the pathogens
against the new arsenal. Recently, a few quantum dots were tested against the pathogenic bacteria and
therefore, justified for potential stockpiling of next-generation antibacterial agents. The key players for
antimicrobial properties of quantum dots are considered to be Reactive Oxygen Species (ROS). The
mechanism of reaction between bacteria and quantum dots needs to be better understood. They are
generally targeted towards the cell wall and membrane components as lipoteichoic acid and phosphatidyl
glycerol of bacteria have been documented here. In this paper, we have attempted to simulate
ZnS quantum dots and have analysed their mechanism of reaction as well as binding potential to the
above bacterial membrane components using CDOCKER. Results have shown a high level of antibacterial
activity towards several pathogenic bacteria which specify their potentiality for future generation
antibacterial drug development.
Keywords: Antibacterial agent, lipoteichoic acid, phosphatidylglycerol, quantum dots, CDOCKER, Multi-Drug Resistant (MDR).
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