Background: Dapsone is a sulfone derived drug used in the treatment of leprosy and several
chronic inflammatory dermatological diseases. Dapsone Hypersensitivity Syndrome (DHS) is
characterized by fever, hepatitis, generalized exfoliative dermatitis and lymphadenopathy. It is rare and
Case Report: We present a case report of a 52 years old female with a recent history of antecedent
dapsone exposure of 100 mg daily for 2 weeks. She developed fever 10 days after exposure to dapsone
therapy and was treated in various primary and tertiary centers for features of sepsis. When she
presented to us, clinical features of multi-organ dysfunction and intractable sepsis was evident. She
was successfully managed with intravenous corticosteroids and other supportive therapy. This case of
DHS is unique due to pulmonary, hepatic and colonic involvement in addition to secondary bacterial
and fungal infection, which is associated with an increased risk of mortality.
Conclusion: As dapsone is mainstay in the treatment several infections and inflammatory conditions,
further research is needed to characterize markers to diagnose DHS and to develop screening policies
prior to initiation of dapsone therapy.