Eyelid Dermatitis and Contact Sensitization to Nickel: Results from an Italian Multi-Centric Observational Study

Author(s): Alessandro Borghi*, Monica Corazza, Elisa Maietti, Cataldo Patruno, Maddalena Napolitano, Donatella Schena, Maria Letizia Musumeci, Giuseppe Micali, Thea Magrone, Paolo Romita, Caterina Foti.

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets

Volume 19 , Issue 1 , 2019

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Graphical Abstract:


Abstract:

Background: Due to the sensitizing constituents of eye cosmetics, allergic contact dermatitis is considered a frequent cause of eyelid dermatitis. An association between eyelid dermatitis and nickel contained in make-ups remains controversial.

Objective: The study aimed to assess the association between nickel allergy, the use of pigmented makeup products and self-reported eyelid dermatitis.

Method: This multi-centric, cross-sectional study enrolled 165 women sensitized to nickel (patients) and 103 women without intolerance to metals (controls). We recorded: demographics, atopy, use of pigmented eye cosmetics (mascara, eyeshadow, eyeliner, eyebrow pencil), and previous eyelid dermatitis. Among the patients, any co-sensitization to cosmetics or metals was recorded.

Results: 87.3% of the patients and 91.3% of the controls reported their use of eye make-up; 44.9% and 52.4%, respectively, reported previous episodes of eyelid dermatitis, without significant differences. The occurrence of eyelid dermatitis was significantly associated with the use of eye make-up products, both in general and considering each product separately. Age, atopy, or co-sensitization to other metals or cosmetics did not affect the occurrence of eyelid dermatitis.

Conclusion: Nickel allergy should not be considered the main risk factor for eyelid dermatitis. The use of pigmented eye make-up may be a triggering factor for eyelid dermatitis, probably due to an irritant action.

Keywords: Eyelid dermatitis, nickel allergy, make-up products, allergic contact dermatitis, cosmetics, irritant contact dermatitis.

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Article Details

VOLUME: 19
ISSUE: 1
Year: 2019
Page: [38 - 45]
Pages: 8
DOI: 10.2174/1871530318666180731114418
Price: $58

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