Background: In the recent times, organo-nano catalysis has emerged as a growing field in
catalytic science with widespread applications in organic synthesis. In the present article, we have focused
on the preparation of an organo-nano catalyst and its application in the synthesis of pyranopyrazole
Method: The catalyst was fabricated by the functionalization of vitamin B1 on silica coated ferrite
(Fe2O3@SiO2) nanoparticles and was characterized by different analytical techniques viz., FT-IR,
TGA, TEM, SEM, EDX, VSM and powder XRD. This organo-nano catalyst was employed for the
one-pot synthesis of pyranopyrazole derivatives from aromatic aldehyde / isatin, malononitrile, hydrazine
hydrate and ethyl acetoacetate in water-ethanol mixture at room temperature stirring condtion.
Results: A library of pyranopyrazole derivatives was synthesized by using a simple, efficient and environmentally
benign protocol. The products obtained were pure with considerably higher yields (87-
98%). The catalyst was easily retrieved from the reaction mixture and reused up to six runs without
any significant decrease in its catalytic activity.
Conculsion: A simple eco-friendly method, mild reaction conditions, high product yields, short reaction
times, easy catalyst recovery and recyclability make this synthetic approach an efficient and sustainable