Background: Ultrasound has been widely used in clinical diagnosis because it is noninvasive,
inexpensive, simple, and reproducible. With the development of molecular imaging, material
science, and ultrasound contrast agents, ultrasound-targeted delivery technology has emerged. The interaction
of ultrasound and molecular probes can be exploited to change the structures of cells and tissues
in order to promote the targeted release of therapeutic substances to local tumors. The targeted
delivery of drugs, genes, and gases would not only improve the efficacy of tumor treatment but also
avoid the systemic toxicity and side effects caused by antitumor treatments. This technology was recently
applied in clinical trials and showed enormous potential for clinical application.
Objective: This article briefly introduces the characteristics of the tumor microenvironment and the
principle of ultrasound-targeted delivery technology. To present recent progress in this field, this review
focuses on the application of ultrasound-targeted delivery technology in tumor-targeted therapy,
including drug delivery, gene transfection, and gas treatment.
Results: The results of this study show that ultrasound-targeted delivery technology is a promising
therapeutic strategy for tumor treatment.
Conclusion: Ultrasound-targeted delivery technology shows promise with regard to cancer treatment.